黄体生成素/绒毛膜促性腺激素受体

Luteinizing hormone/choriogonadotropin receptor; 黄体生成素/绒毛膜促性腺激素受体
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1LUT, 1XUL
标识
代号	LHCGR; HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHR; LHRHR; LSH-R; ULG5
扩展标识	遗传学：152790 鼠基因：96783 同源基因：37276 IUPHAR: LH ChEMBL: 1854 GeneCards: LHCGR Gene
基因本体论描述
分子功能	· luteinizing hormone receptor activity; · choriogonadotropin hormone receptor activity; · choriogonadotropin hormone binding;
细胞成分	· endosome; · plasma membrane; · integral to plasma membrane;
生物过程	· ovarian follicle development; · G-protein coupled receptor signaling pathway; · G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; · activation of adenylate cyclase activity; · phospholipase C-activating G-protein coupled receptor signaling pathway; · spermatogenesis; · male gonad development; · male genitalia development; · positive regulation of inositol trisphosphate biosynthetic process; · positive regulation of cAMP-mediated signaling; · development of secondary male sexual characteristics; · uterus development; · cellular response to gonadotropin stimulus; · seminiferous tubule development; · regulation of steroid hormone biosynthetic process;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

黄体生成素/绒毛膜促性腺激素受体（英語：，缩写LHCGR也作 lutropin/choriogonadotropin receptor，LCGR或luteinizing hormone receptor，LHR ）是一种主要出现在卵巢和睾丸的跨膜受体，但在一些性腺外的器官如子宫和乳房也有表达。该受体是G蛋白偶联受体（GPCR）的一种，既能与黄体生成素（LH）互作也能与绒毛膜促性腺激素（如人类的hCG），其激活是在繁殖期间的荷尔蒙运作所需的。

LHCGR基因

LHCGR位于人类基因组上的2號染色體p21区，接近类似的促卵泡激素受体（FSHR）基因，长约70Kbp（FSHR为54Kpb）[1]，除了与FSHR相似外，还类似于促甲状腺激素受体（TSHR）。

历史

馬丁·羅德貝爾与艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖。

相互作用

黄体生成素/绒毛膜促性腺激素受体与GIPC1能进行相互作用[2]。

参考文献

Simoni M, Gromoll J, Nieschlag E. . Endocr. Rev. 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.
Hirakawa, Takashi; Galet Colette, Kishi Mikiko, Ascoli Mario. . J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200.

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外部链接

. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
GRIS: Glycoprotein-hormone Receptor Information System
MeSH（醫學主題詞）上面的LH-hCG+Receptors（美式英语）

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[FSHR-1] Simoni M, Gromoll J, Nieschlag E. . Endocr. Rev. 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.

[pmid14507927-2] Hirakawa, Takashi; Galet Colette, Kishi Mikiko, Ascoli Mario. . J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200.