催乳素受体

催乳素受体（英語：）由染色体5p13-14区段的基因编码，作为一种跨膜受体与催乳素相互作用。

prolactin receptor 催乳素受体
識別
符號 PRLR
Entrez 5618
HUGO 9446
OMIM 176761
PDB 1RW5
RefSeq NM_000949
UniProt P16471
其他資料
基因座 5 p13-p12

它包括一个胞外区以结合催乳素，一个跨膜区，以及一个胞内区域。

该受体属于细胞因子受体[1]，其第二信使信号通过JAK-STAT信号通路、JAK-RUSH信号通路[2][3]、Ras-Raf-MAPK和PI-3K[4]途径级联放大。

不同组织的催乳素受体可能会有所变化[5]。

参考文献
  1. Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
  2. Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
  3. Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
  4. The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
  5. Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.

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