小髮夾RNA

小髮夾RNA（英語：，缩写）是一種形成急轉彎（hairpin turn）結構的RNA序列，可以經由RNA干擾（RNAi）使基因表現沉默化。shRNA可利用載體導入細胞當中，並藉由U6啟動子來確保shRNA的表現。另外，shRNA可經由切割轉變成為siRNA

參考文獻
    • McIntyre G, Fanning G. . BMC Biotechnol. 2006, 6: 1. PMID 16396676.
    • Harper S, Staber P, He X, Eliason S, Martins I, Mao Q, Yang L, Kotin R, Paulson H, Davidson B. . Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (16): 5820–5. PMID 15811941.
    • Nielsen M, Pedersen F, Kjems J. . Retrovirology. 2005, 2: 10. PMID 15715913.
    • Paddison P, Caudy A, Bernstein E, Hannon G, Conklin D. . Genes Dev. 2002, 16 (8): 948–58. PMID 11959843.
    • Cao W, Hunter R, Strnatka D, McQueen C, Erickson R. (PDF). J. Appl. Genet. 2005, 46 (2): 217–25. PMID 15876690.

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