核小體
核小体是由DNA與4對組織蛋白（共8個）组成的複合物，其中有H2A和H2B的二聚體兩組以及H3和H4的二聚體兩組。另外還有一種H1負責連結兩個核小體之間的DNA。
核小體（英語：，也译作核體或核仁小體等）是組成真核生物染色質（除精子染色質外）的基本單位。
核小體假說是在1974年，由Don Olins、Ada Olins[1]與羅傑·科恩伯格[2][3]等人首次提出的。
染色质的压缩模式
核小体的组成示意图
参见
- 前核小体
參考文獻
- AL and Olins DE, "Spheroid Chromatin Units (nu Bodies)", Science (1974); 183: 330 - 332
- McDonald D, "Milestone 9, (1973-1974) The nucleosome hypothesis: An alternative string theory", Nature Milestones: Gene Expression. (2005) Dec 1; http://www.nature.com/milestones/geneexpression/milestones/articles/milegene09.html
- Kornberg, RD, "Chromatin structure: a repeating unit of histones and DNA", Science. (1974); 184: 868–871
外部链接
- Nucleosomes on the group page of Timothy Richmond
- 蛋白质数据库中有关核小体的资料
- Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation
- Catalog of servers with experimental data and prediction tools for nucleosome positioning
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