模式识别受体
模式识别受体(pattern recognition receptors)为免疫系统细胞表达的，与病原微生物或细胞应激相关的蛋白。可以被模式识别受体识别的微生物特定分子为病原相关分子模式。包括细菌的碳水化合物(如脂多糖和甘露糖)；革兰氏阳性菌的肽聚糖和脂磷壁酸，及真菌多糖.
根据其功能，模式识别受体可分为细胞内吞噬受体或信号受体。信号受体包括细胞膜连的Toll样受体[1]及胞浆内NOD样受体。内吞噬受体促进吞噬细胞对微生物的附着，吞噬和破坏，而不传道细胞信号。
分类
膜连受体
- 類Toll受体: 類Toll受体1 至類Toll受体11。
- 甘露糖受体[2]
参考文献
- Beutler et al. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large. Annual Review of Immunology Volume 24, pages 353-389.
- Apostolopoulos and McKenzie. Role of the Mannose Receptor in the Immune Response. Current Molecular Medicine 2001, Volume 1, pages 469-474.
- Ting JP, Williams KL. The CATERPILLER family: an ancient family of immune/apoptotic proteins. Clinical Immunology, 2005, Volume 115(1):33-7.
- Strober et al., Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006, Volume 6(1):9-20.
- Dommett et al., Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 2006, Volume 68 Issue 3 Page 193
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