白细胞介素-4

Il4
識別號
别名	；interleukin 4BSF-1Il-4
外部ID	HomoloGene：491 GeneCards：
基因位置（人类）
染色体	染色体11（人类）
终止	53,618,669 bp
基因本體
分子功能	• 細胞因子活性; • 白细胞介素-4受体结合; • 生長因子活性; • 細胞因子受體結合;
細胞組分	• 細胞外區域; • external side of plasma membrane; • 細胞外空間;
生物學過程	• positive regulation of MHC class II biosynthetic process; • positive regulation of isotype switching to IgE isotypes; • positive regulation of protein phosphorylation; • T-helper 2 cell differentiation; • negative regulation of osteoclast differentiation; • T-helper 1 cell lineage commitment; • positive regulation of immunoglobulin production; • negative regulation of extrinsic apoptotic signaling pathway; • positive regulation of sequence-specific DNA binding transcription factor activity; • cholesterol metabolic process; • B cell costimulation; • positive regulation of mast cell degranulation; • negative regulation of white fat cell proliferation; • B cell activation; • positive regulation of myoblast fusion; • innate immune response in mucosa; • positive regulation of B cell proliferation; • 免疫反应; • positive regulation of T cell proliferation; • extrinsic apoptotic signaling pathway in absence of ligand; • regulation of immune response; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of B cell activation; • positive regulation of isotype switching to IgG isotypes; • negative regulation of T cell activation; • negative regulation of T-helper 17 cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of activated T cell proliferation; • defense response to protozoan; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of receptor activity; • negative regulation of epithelial cell migration; • positive regulation of interleukin-13 production; • T-helper 2 cell cytokine production; • myeloid dendritic cell differentiation; • positive regulation of T cell differentiation; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • dendritic cell differentiation; • negative regulation of complement-dependent cytotoxicity; • 內皮細胞凋亡過程的負調控; • T cell activation; • microglial cell activation; • positive regulation of defense response to virus by host; • negative regulation of acute inflammatory response; • negative regulation of chronic inflammatory response; • positive regulation of cell proliferation; • regulation of proton transport; • positive regulation of interleukin-10 production; • negative regulation of macrophage activation; • negative regulation of nitric oxide biosynthetic process; • regulation of inflammatory response; • positive regulation of mononuclear cell migration; • positive regulation of reactive oxygen species biosynthetic process; • positive regulation of eosinophil chemotaxis; • 自噬; • positive regulation of gene expression; • positive regulation of macroautophagy; • activation of Janus kinase activity; • positive regulation of receptor-mediated endocytosis; • positive regulation of cold-induced thermogenesis; • positive regulation of amyloid-beta clearance; • positive regulation of cellular respiration; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	16189
	n/a
	ENSMUSG00000000869
	n/a
	P07750
	P07750
	NM_021283、NR_027491
	n/a
	NP_067258
	NP_067258
	維基數據

白细胞介素-4（白介素-4, Interleukin-4, IL-4）是II型辅助T细胞（Th2细胞）分泌的细胞因子。白细胞介素-4的生物作用，包括刺激活化B细胞和T细胞增殖、 CD4+T细胞分化成II型辅助T细胞. 它也在调节体液免疫和适应性免疫中起关键作用。白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型主要组织兼容性复合体的产生。这一因子是由M.霍华德、W.保罗和E. 委特塔（Vitetta）在1982共同发现的。四年后人类白细胞介素-4的核苷酸序列中被分离，证实它与一小鼠蛋白B细胞刺激因子-1（BCSF-1）类似[2].

参看

参考文献

. National Center for Biotechnology Information, U.S. National Library of Medicine.
Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

外部链接

MeSH|Interleukin+4

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.