短链脱氢酶

現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

short chain dehydrogenase
	[1]
鑑定
標誌	adh_short
Pfam	PF00106
InterPro	IPR002198
PROSITE	PDOC00060
SCOP	1hdc / SUPFAM
OPM家族	119
OPM蛋白	1xu7
CDD	cd02266
膜蛋白數據庫	246
現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

短链脱氢酶（英語：，或称为短链脱氢/还原酶家族，英語：，缩写SDR）[2]是一个非常大的蛋白质家族，属于 NAD- 或 NADP-依赖的氧化還原酶，第一个被鉴定的家族成员是黑腹果蝇的醇脱氢酶，因此命名为“昆虫型”（'insect-type'）或“短链”（'short-chain'）醇脱氢酶[3][4][5]。大部分酶家族成员有250到300个氨基酸残基，且包含至少两个结构域[6]其中一个用于结合辅酶，大部分是NAD，少部分是NADP，另一个用于结合底物及催化。

人类基因组中的成员

BDH1; BDH2; CBR1; CBR3; CBR4; DCXR; DECR1; DECR2; DHRS1; DHRS10; DHRS13; DHRS2; DHRS3; DHRS4; DHRS4L2; DHRS7; DHRS7B; DHRS8; DHRS9; DHRSX; FASN; FVT1; HADH2; HPGD; HSD11B1; HSD11B2; HSD17B1; HSD17B10; HSD17B12; HSD17B13; HSD17B2; HSD17B3; HSD17B4; HSD17B6; HSD17B7; HSD17B7P2; HSD17B8; HSDL1; HSDL2; PECR; QDPR; RDH10; RDH11; RDH12; RDH13; RDH14; RDH16; RDH5; RDH8; RDHE2; RDHS; SCDR10; SPR; WWOX;

参考文献

Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W. . Structure. October 1994, 2 (10): 973–80. PMID 7866748. doi:10.1016/S0969-2126(94)00099-9.
Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D, Jornvall H. . Biochemistry. 1995, 34 (18): 6003–6013. PMID 7742302. doi:10.1021/bi00039a038.
Villarroya A, Juan E, Egestad B, Jornvall H. . Eur. J. Biochem. 1989, 180 (1): 191–197. PMID 2707261. doi:10.1111/j.1432-1033.1989.tb14632.x.
Persson B, Krook M, Jornvall H. . Eur. J. Biochem. 1991, 200 (2): 537–543. PMID 1889416. doi:10.1111/j.1432-1033.1991.tb16215.x.
Harayama S, Bairoch A, Hartnett C, Rekik M, Ornston LN, Neidle E. . Eur. J. Biochem. 1992, 204 (1): 113–120. PMID 1740120. doi:10.1111/j.1432-1033.1992.tb16612.x.
Benyajati C, Place AR, Powers DA, Sofer W. . Proc. Natl. Acad. Sci. U.S.A. 1981, 78 (5): 2717–2721. PMC 319428. PMID 6789320. doi:10.1073/pnas.78.5.2717.

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[pmid7866748-1] Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W. . Structure. October 1994, 2 (10): 973–80. PMID 7866748. doi:10.1016/S0969-2126(94)00099-9.

[PUB00000419-2] Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D, Jornvall H. . Biochemistry. 1995, 34 (18): 6003–6013. PMID 7742302. doi:10.1021/bi00039a038.

[PUB00001371-3] Villarroya A, Juan E, Egestad B, Jornvall H. . Eur. J. Biochem. 1989, 180 (1): 191–197. PMID 2707261. doi:10.1111/j.1432-1033.1989.tb14632.x.

[PUB00001399-4] Persson B, Krook M, Jornvall H. . Eur. J. Biochem. 1991, 200 (2): 537–543. PMID 1889416. doi:10.1111/j.1432-1033.1991.tb16215.x.

[PUB00001408-5] Harayama S, Bairoch A, Hartnett C, Rekik M, Ornston LN, Neidle E. . Eur. J. Biochem. 1992, 204 (1): 113–120. PMID 1740120. doi:10.1111/j.1432-1033.1992.tb16612.x.

[PUB00004592-6] Benyajati C, Place AR, Powers DA, Sofer W. . Proc. Natl. Acad. Sci. U.S.A. 1981, 78 (5): 2717–2721. PMC 319428. PMID 6789320. doi:10.1073/pnas.78.5.2717.