粘杆菌素
粘杆菌素(Colistin),又名克痢霉素、多粘菌素E,是一种多粘菌素类多肽抗生素,是两种环状多肽——粘杆菌素A和B的混合物。可由多粘芽肥杆菌变种粘菌素(Bacillus polymyxa var. colistinus)产生。对多数革兰氏阴性菌有效,但具肝毒性与神经毒性,故被视为“最后一线药物”[1]。
系统(IUPAC)命名名称 | |
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N-(4-amino-1-(1-(4-amino-1-oxo-1-(3,12,23-tris(2-aminoethyl)- 20-(1-hydroxyethyl)-6,9-diisobutyl-2,5,8,11,14,19,22-heptaoxo- 1,4,7,10,13,18-hexaazacyclotricosan-15-ylamino)butan-2-ylamino)- 3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-N,5-dimethylheptanamide | |
临床数据 | |
妊娠分级 |
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给药途径 | topical, oral, intravenous |
合法狀態 | |
合法状态 |
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药代动力学数据 | |
生物利用度 | 0% |
生物半衰期 | 5 hours |
识别 | |
CAS注册号 | 1264-72-8 |
ATC代码 | A07AA10 J01 QJ51 |
PubChem | CID 5311054 |
DrugBank | APRD00886 |
化学 | |
化学式 | C52H98N16O13 |
摩尔质量 | 1155,4495 g/mol |
參見
註釋
外部連結
- Colistin topics page (bibliography) on Science.gov
- Protocol for PCR detection of the gene mcr-1 gene on the National Food Institute website at the Technical University of Denmark
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