血管紧张素转化酶2

血管紧张素转化酶2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3SCL、1R42、1R4L、2AJF、3D0G、3D0H、3D0I、3KBH、3SCI、3SCJ、3SCK
識別號
别名	ACE2；, ACEH, angiotensin I converting enzyme 2
外部ID	OMIM：300335 MGI：1917258 HomoloGene：41448 GeneCards：ACE2
基因位置（人类）
染色体	X染色體[1]
终止	15,602,148 bp[1]
基因位置（小鼠）
染色体	小鼠X染色体[2]
终止	164,188,420 bp[2]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• peptidyl-dipeptidase activity; • virus receptor activity; • 鋅離子結合; • endopeptidase activity; • 金屬離子結合; • 肽酶活性; • 血浆蛋白结合; • carboxypeptidase activity; • 水解酶活性; • metallopeptidase activity; • metallocarboxypeptidase activity; • exopeptidase activity;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • 細胞外區域; • cell surface; • 脂筏模型; • 外排體; • 細胞外空間; • brush border membrane;
生物學過程	• regulation of cardiac conduction; • angiotensin-mediated drinking behavior; • 蛋白酶解; • regulation of cytokine production; • positive regulation of reactive oxygen species metabolic process; • regulation of vasoconstriction; • regulation of cell proliferation; • positive regulation of cardiac muscle contraction; • regulation of inflammatory response; • positive regulation of gap junction assembly; • viral entry; • viral process; • regulation of systemic arterial blood pressure by renin-angiotensin; • tryptophan transport; • regulation of blood vessel diameter; • angiotensin maturation; • receptor-mediated virion attachment to host cell; • positive regulation of amino acid transport;
	Sources:Amigo / QuickGO
直系同源
	59272
	70008
	ENSG00000130234
	ENSMUSG00000015405
	Q9BYF1
	Q8R0I0
	NM_021804; NM_001371415
	NM_001130513; NM_027286
	NP_068576; NP_001358344
	NP_001123985; NP_081562
	維基數據

血管紧张素转化酶2（英語：，）是一種附著在肺，動脈，心臟，腎臟和腸道中細胞表面（細胞膜）上的酶。是一种能催化血管紧张素I转化为血管紧张素-（1-9）[5]或血管紧张素II转化为血管紧张素-（1-7）[6]的外肽酶。此外，ACE2还是SARS 冠状病毒（SARS-CoV）、嚴重急性呼吸系統綜合症冠狀病毒2型（SARS-CoV-2）和人類冠狀病毒NL63的受体[7]。 ACE2对ACE抑制剂药物不敏感 [8]。

参考文献

GRCh38: Ensembl release 89: ENSG00000130234 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015405 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
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延伸閲讀

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参见

外部連結

Human ACE2 genome location and ACE2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130234 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015405 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10969042-5] Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. . Circ. Res. 2000, 87 (5): E1–9. PMID 10969042.

[pmid17049503-6] Keidar S, Kaplan M, Gamliel-Lazarovich A. . Cardiovasc Res. 2007, 73 (3): 463–9. PMID 17049503.

[pmid16339739-7] Weiss SR, Navas-Martin S. . Microbiol Mol Biol Rev. 2005, 69 (4): 635–64. PMID 16339739.

[8] Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. . Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021.