过氧化物酶体增殖物活化受体γ

过氧化物酶体增殖物活化受体γPeroxisome proliferator-activated receptor gamma ,缩写为PPAR-γPPARG),也称胰島素增敏劑受体(glitazone receptor),或 NR1C3(意为核受体第一亚科C集团第3号,nuclear receptor subfamily 1, group C, member 3)是一种位于人类染色体上的二型核受体,由PPARG基因编码。[2][3][4]脂肪细胞胰岛素有重要的作用,是治疗糖尿病的研究对象之一。[5]

过氧化物酶体增殖物活化受体γ
PPAR-G dimer bound to DNA. PDB rendering based on 3e00[1].
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 PPARG; CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
扩展标识 遗传学601487 鼠基因97747 同源基因7899 IUPHAR:   ChEMBL: 235 GeneCards: PPARG Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 5468 19016
Ensembl ENSG00000132170 ENSMUSG00000000440
UniProt P37231 P37238
mRNA序列 NM_005037 NM_001127330
蛋白序列 NP_005028 NP_001120802
基因位置 Chr 3:
12.33 – 12.48 Mb
Chr 6:
115.36 – 115.49 Mb
PubMed查询

来源

  1. Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P. Burris, Fraydoon Rastinejad. . Nature. 2008-11-20, 456 (7220): 350–356 [2019-05-26]. ISSN 1476-4687. PMC PMCPMC2743566 请检查|pmc=值 (帮助). PMID 19043829. doi:10.1038/nature07413.
  2. Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, Hsieh L, Greene G, Nimer SD. . Gene Expr. 1995, 4 (4-5): 281–99. PMID 7787419.
  3. Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J. . Biochem. Biophys. Res. Commun. July 1996, 224 (2): 431–7. PMID 8702406. doi:10.1006/bbrc.1996.1044.
  4. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. . Pharmacol. Rev. December 2006, 58 (4): 726–41. PMID 17132851. doi:10.1124/pr.58.4.5.
  5. 刘英姿 ,刘昭前 , 周宏灏. (PDF). 中国临床药理学杂志. 2007, 23 (4): 308–310. 1001-6821(2007)04-0308-03 (中文).
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