鲨烯-藿烯环化酶
鲨烯-藿烯环化酶（英語：，缩写SHC，EC 5.4.99.17）或称作藿烷-22-醇水裂解酶（hopan-22-ol hydro-lyase，EC 4.2.1.129）属于原核生物中生成五环三萜的环化/变位酶家族，能催化下列两种反应，生成藿烯或藿烷-22-醇，两种产物的比例为5比1[1][2][3][4][5]：
- 鲨烯 22(29)-藿烯
- 鲨烯 + H2O 藿烷-22-醇
| Squalene-hopene cyclase | |||||||
|---|---|---|---|---|---|---|---|
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| 鲨烯-藿烯环化酶二聚体的晶体结构 | |||||||
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| 识别码 | |||||||
| EC编号 | or 4/2/1/129.html 5.4.99.17 | ||||||
| CAS号 | 76600-69-6 | ||||||
| 数据库 | |||||||
| IntEnz | IntEnz浏览 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme浏览 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代谢路径 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
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参考文献
- Hoshino T, Sato T. . Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.
- Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. . Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.
- Sato T, Kouda M, Hoshino T. . Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.
- Reinert DJ, Balliano G, Schulz GE. . Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.
- Pearson A, Budin M, Brocks JJ. . Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571. PMID 14660793. doi:10.1073/pnas.2536559100.
外部链接
- MeSH（醫學主題詞）上面的Squalene-hopene+cyclase（美式英语）
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