齐雷索韦

**齐雷索韦**
系统（IUPAC）命名名称
	N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-2H-1λ6,4-benzothiazepin-4-yl)-6-methylquinazolin-4-amine
临床数据
商品名	Ziresovir
合法狀態
合法状态	US: Investigational New Drug ;
识别
CAS注册号	1422500-60-4
PubChem	CID 71262247
ChemSpider	58810221
UNII	XCF42D7AG4
化学
化学式	C22H25N5O3S
摩尔质量	439.5
	SMILES CC1=CC2=C(C=C1)N=C(N=C2NCC3(COC3)N)N4CCS(=O)(=O)C5=CC=CC=C5C4;
	InChI InChI=1S/C22H25N5O3S/c1-15-6-7-18-17(10-15)20(24-12-22(23)13-30-14-22)26-21(25-18)27-8-9-31(28,29)19-5-3-2-4-16(19)11-27/h2-7,10H,8-9,11-14,23H2,1H3,(H,24,25,26); Key:GAAICKUTDBZCMT-UHFFFAOYSA-N;

齐雷索韦（ziresovir、RO-0529、AK0529，化学式C₂₂H₂₅N₅O₃S）是一种抗病毒药，被开发用于治疗呼吸道合胞病毒感染。它作为一种融合抑制剂，在II期临床试验中显示出较好的疗效。[1][2]

参见

Zheng X, Gao L, Wang L, Liang C, Wang B, Liu Y, Feng S, Zhang B, Zhou M, Yu X, Xiang K, Chen L, Guo T, Shen HC, Zou G, Wu JZ, Yun H. Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor. J Med Chem. 2019 Jul 11;62(13):6003-6014. doi:10.1021/acs.jmedchem.9b00654 PubMed
Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC. Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res. 2019 Jul;167:45-67. PubMed doi:10.1016/j.antiviral.2019.04.006

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