CCL1

CCL1英語:)是一小分子的细胞因子属于CC趋化因子家族,是由活化的T细胞分泌的糖蛋白[1]。CCL1与细胞表面的趋化因子受体CCR8结合[2]。CCL1对单核细胞自然杀伤细胞,未成熟的B细胞树突状细胞有细胞趋化作用[1]。人类的CCL1基因与许多CC趋化因子的基因相邻聚集在第17染色体上[3].

趋化因子(C-C基序)配体1
識別
符號 CCL1
替換符號 SCYA1, I-309, TCA3, P500, SISe
Entrez 6346
HUGO 10609
OMIM 182281
PDB 1EL0
RefSeq NM_002981
UniProt P22362
其他資料
基因座 17 q11.2

参见

参考文献

  1. Miller MD, Krangel MS. The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4.
  2. Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem. 1997 Jul 11;272(28):17251-4.
  3. Miller MD, Wilson SD, Dorf ME, Seuanez HN, O'Brien SJ, Krangel MS. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol. 1990 Oct 15;145(8):2737-44.

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