CYP27A1

CYP27A1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1MFX
識別號
别名	CYP27A1；, CP27, CTX, CYP27, cytochrome P450 family 27 subfamily A member 1
外部ID	OMIM：606530 MGI：88594 HomoloGene：36040 GeneCards：CYP27A1
相關疾病
	腦腱性黃瘤症[1]
基因位置（人类）
染色体	染色体2（人类）[2]
终止	218,815,293 bp[2]
基因位置（小鼠）
染色体	染色体1（小鼠）[3]
终止	74,737,892 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• monooxygenase activity; • iron ion binding; • steroid hydroxylase activity; • oxidoreductase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • 金屬離子結合; • vitamin D3 25-hydroxylase activity; • cholesterol 26-hydroxylase activity; • cholestanetriol 26-monooxygenase activity;
細胞組分	• 线粒体基质; • 膜; • mitochondrial membranes; • 線粒體; • mitochondrial inner membrane;
生物學過程	• sterol metabolic process; • bile acid biosynthetic process; • oxidation-reduction process; • cholesterol catabolic process; • calcitriol biosynthetic process from calciol; • 脂質代謝; • steroid biosynthetic process; • steroid metabolic process; • cholesterol metabolic process;
	Sources:Amigo / QuickGO
直系同源
	1593
	104086
	ENSG00000135929
	ENSMUSG00000026170
	Q02318
	Q9DBG1
	NM_000784、XM_017003488
	NM_024264、XM_006495607
	NP_000775、XP_016858977
	NP_077226、XP_006495670
	維基數據

细胞色素 P450 27A1（英語：，缩写CYP27A1）也被称为甾醇-27-羟化酶（，EC 1.14.15.15），是细胞色素P450超家族的一员，由CYP27A1基因编码，是定位于许多不同组织线粒体内膜的单加氧酶，能催化多种甾醇侧链上27号位以及其它位置的羟基化，如在胆汁酸合成中催化胆固醇生成27-羟基胆固醇[6]，在维生素D合成代谢中催化胆钙化醇（维生素D₃）生成骨化二醇（25-羟基维生素D₃）[7]。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000135929 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026170 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Chiang JY. . Frontiers in Bioscience. February 1998, 3 ( ): d176–93. PMID 9450986. doi:10.2741/a273.
Gascon-Barré, M; Demers, C; Ghrab, O; Theodoropoulos, C; Lapointe, R; Jones, G; Valiquette, L; Ménard, D. . Clinical endocrinology. 2001-01, 54 (1): 107–15. PMID 11167933. doi:10.1046/j.1365-2265.2001.01160.x.

外部链接

GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis 页面存档备份，存于
MeSH（醫學主題詞）上面的Cytochrome+P-450+CYP27A1（美式英语）
Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser.

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000135929 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000026170 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9450986-6] Chiang JY. . Frontiers in Bioscience. February 1998, 3 ( ): d176–93. PMID 9450986. doi:10.2741/a273.

[7] Gascon-Barré, M; Demers, C; Ghrab, O; Theodoropoulos, C; Lapointe, R; Jones, G; Valiquette, L; Ménard, D. . Clinical endocrinology. 2001-01, 54 (1): 107–15. PMID 11167933. doi:10.1046/j.1365-2265.2001.01160.x.