CpG寡脱氧核苷酸

CpG寡脱氧核苷酸（英語：，CpG ODN）是短的单链DNA分子，其序列包含一个胞嘧啶脱氧核苷酸 ("C")，紧接着一个鳥嘌呤脱氧核苷酸 ("G")，"p"是指两者之间的磷酸二酯鍵链接。当CpG寡脱氧核苷酸处于未甲基化的状态时，可以作为免疫增强剂[1]。未甲基化的CpG ODN是一种病原相关分子模式，因为其在脊椎动物的基因组中很稀有，而在微生物的基因组中很丰富。[2]。CpG ODN是公认的模式识别受体（PRR）Toll样受9（TLR9）的配体，TLR9只在人类和其他较高的灵长类动物的B细胞和浆细胞样树突状细胞（pDC）中表达。[3]

不同类别的CpG ODN 在浆细胞样树突状细胞（pDC）和B细胞中引起的反应不同

参考文献

Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. . Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500. PMID 9380720. doi:10.1073/pnas.94.20.10833.
Bauer, S; Wagner, H. . Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.
Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. . Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.

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[pmid9380720-1] Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. . Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500. PMID 9380720. doi:10.1073/pnas.94.20.10833.

[Bacterial_CpG-DNA_licenses_TLR9-2] Bauer, S; Wagner, H. . Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.

[pmid12480254-3] Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. . Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.