FokI

FokI是一種存在於細菌Flavobacterium okeanokoites的type IIS限制酶,含有位於N端DNA結合區塊(N-terminal DNA-binding domain),以及一個位於C端的非專一性DNA切割區塊[2]。當此酵素與DNA辨識並結合於5'-GGATG-3'识别位点時,將會把位於結合位置下游的9到13個核苷酸切除(不需特定序列)[3]FokI的分子量為65.4 kDA,含有587個氨基酸

Restriction endonuclease Fok1, C terminal
Fok1结合DNA的PDB图像:1fok[1]
鑑定
標誌Endonuc-Fok1_C
PfamPF09254
Pfam宗系CL0415
InterProIPR015334
 SCOP2fok / SUPFAM

參考文獻

  1. Aggarwal, A. K.; Wah, D. A.; Hirsch, J. A.; Dorner, L. F.; Schildkraut, I. . Nature. 1997, 388 (6637): 97–100. PMID 9214510. doi:10.1038/40446.
  2. Durai S, Mani M, Kandavelou K, Wu J, Porteus M, Chandrasegaran S. . Nucleic Acids Res. 2005, 33 (18): 5978–90 [2007-07-20]. PMID 16251401. (原始内容存档于2007-05-10).
  3. Wah, D. A.; J. Bitinaite, Schildkraut, I., Aggarwal, A. K. . Proc Natl Acad Sci U S A. 1998, 95 (18): 10564–9.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.