SRY基因

SRY基因
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1HRY、1HRZ、1J46、1J47、2GZK
識別號
别名	SRY；, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
外部ID	OMIM：480000 MGI：98660 HomoloGene：48168 GeneCards：SRY
基因位置（人类）
染色体	Y染色体（人类）[1]
终止	2,787,682 bp[1]
基因位置（小鼠）
染色体	Y染色体（小鼠）[2]
终止	2,663,658 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合转录因子活性; • 转录因子结合; • calmodulin binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA结合; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 血浆蛋白结合; • DNA-binding transcription activator activity, RNA polymerase II-specific;
細胞組分	• 細胞質; • nuclear speck; • 核质; • 细胞核;
生物學過程	• 细胞分化; • regulation of transcription, DNA-templated; • sex differentiation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • positive regulation of male gonad development; • male sex determination; • regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • central nervous system development; • positive regulation of gene expression; • neuron differentiation;
	Sources:Amigo / QuickGO
直系同源
	6736
	21674
	ENSG00000184895
	ENSMUSG00000069036
	Q05066
	Q05738
	NM_003140
	NM_011564
	NP_003131
	NP_035694
	維基數據

SRY基因（sex-determining region of Y-chromosome，全称：Y染色体性别决定区），又名睪丸決定因子，（英語：Testis-determining factor，簡稱TDF）是人体Y染色体上的一段基因片段，该基因是决定男性睾丸发育的主要基因。存在于Y染色体的短臂末端上。

该基因由Sinclair在1990年发现。

有些人宣稱，SRY基因就是唯一一个性别决定基因，因此可以通过寻找该基因片断，达到判断测试者的性别的目的，若样本中存在该基因表示受试者是男性，否則为女性。然而一篇有一千六百餘名科學家簽名的聲明（包括700 名生物學者、100名遺傳學者、9名諾貝爾獎得主）指出：目前不存在任何方式可以準確地判斷生理性別，且即使有辦法判斷，也不應該因此限制人們追求不同的自我認同。[5]

註釋

GRCh38: Ensembl release 89: ENSG00000184895 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000069036 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. BBC. 2018-11-02 [2019-01-19]. （原始内容存档于2019-01-20）（英语）.

延伸阅读

Haqq CM, King CY, Ukiyama E, Falsafi S, Haqq TN, Donahoe PK, Weiss MA. . Science. December 1994, 266 (5190): 1494–500. Bibcode:1994Sci...266.1494H. PMID 7985018. doi:10.1126/science.7985018.
Goodfellow PN, Lovell-Badge R. . Annual Review of Genetics. 1993, 27: 71–92. PMID 8122913. doi:10.1146/annurev.ge.27.120193.000443.
Hawkins JR. . Human Mutation. 1993, 2 (5): 347–50. PMID 8257986. doi:10.1002/humu.1380020504.
Harley VR. . Novartis Found. Symp. Novartis Foundation Symposia 244. 2002: 57–66; discussion 66–7, 79–85, 253–7. ISBN 978-0-470-86873-7. PMID 11990798. doi:10.1002/0470868732.ch6.
Jordan BK, Vilain E. . Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology 511. 2003: 1–13; discussion 13–4. ISBN 978-1-4613-5162-7. PMID 12575752. doi:10.1007/978-1-4615-0621-8_1.
Oh HJ, Lau YF. . Molecular and Cellular Endocrinology. March 2006, 247 (1–2): 47–52. PMID 16414182. doi:10.1016/j.mce.2005.12.011.
Polanco JC, Koopman P. . Developmental Biology. February 2007, 302 (1): 13–24. PMID 16996051. doi:10.1016/j.ydbio.2006.08.049.
Hawkins JR, Taylor A, Berta P, Levilliers J, Van der Auwera B, Goodfellow PN. . Human Genetics. February 1992, 88 (4): 471–4. PMID 1339396. doi:10.1007/BF00215684.
Hawkins JR, Taylor A, Goodfellow PN, Migeon CJ, Smith KD, Berkovitz GD. . American Journal of Human Genetics. November 1992, 51 (5): 979–84. PMC 1682856. PMID 1415266.
Ferrari S, Harley VR, Pontiggia A, Goodfellow PN, Lovell-Badge R, Bianchi ME. . The EMBO Journal. December 1992, 11 (12): 4497–506. PMC 557025. PMID 1425584. doi:10.1002/j.1460-2075.1992.tb05551.x.
Jäger RJ, Harley VR, Pfeiffer RA, Goodfellow PN, Scherer G. . Human Genetics. December 1992, 90 (4): 350–5. PMID 1483689. doi:10.1007/BF00220457.
Vilain E, McElreavey K, Jaubert F, Raymond JP, Richaud F, Fellous M. . American Journal of Human Genetics. May 1992, 50 (5): 1008–11. PMC 1682588. PMID 1570829.
Müller J, Schwartz M, Skakkebaek NE. . The Journal of Clinical Endocrinology and Metabolism. July 1992, 75 (1): 331–3. PMID 1619028. doi:10.1210/jc.75.1.331.
McElreavey KD, Vilain E, Boucekkine C, Vidaud M, Jaubert F, Richaud F, Fellous M. . Genomics. July 1992, 13 (3): 838–40. PMID 1639410. doi:10.1016/0888-7543(92)90164-N.
Sinclair AH, Berta P, Palmer MS, Hawkins JR, Griffiths BL, Smith MJ, Foster JW, Frischauf AM, Lovell-Badge R, Goodfellow PN. . Nature. July 1990, 346 (6281): 240–4. Bibcode:1990Natur.346..240S. PMID 1695712. doi:10.1038/346240a0.
Berkovitz GD, Fechner PY, Zacur HW, Rock JA, Snyder HM, Migeon CJ, Perlman EJ. . Medicine. November 1991, 70 (6): 375–83. PMID 1956279. doi:10.1097/00005792-199111000-00003.
Berta P, Hawkins JR, Sinclair AH, Taylor A, Griffiths BL, Goodfellow PN, Fellous M. . Nature. November 1990, 348 (6300): 448–50. Bibcode:1990Natur.348..448B. PMID 2247149. doi:10.1038/348448A0.
Jäger RJ, Anvret M, Hall K, Scherer G. . Nature. November 1990, 348 (6300): 452–4. Bibcode:1990Natur.348..452J. PMID 2247151. doi:10.1038/348452a0.
Ellis NA, Goodfellow PJ, Pym B, Smith M, Palmer M, Frischauf AM, Goodfellow PN. . Nature. January 1989, 337 (6202): 81–4. Bibcode:1989Natur.337...81E. PMID 2909893. doi:10.1038/337081a0.
Whitfield LS, Hawkins TL, Goodfellow PN, Sulston J. . Genomics. May 1995, 27 (2): 306–11. PMID 7557997. doi:10.1006/geno.1995.1047.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184895 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069036 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . BBC. 2018-11-02 [2019-01-19]. （原始内容存档于2019-01-20）（英语）.

SRY基因

相關條目

註釋

延伸阅读