TATA结合蛋白

現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

TBP
	crystal structure of a yeast brf1-tbp-dna ternary complex
鑑定
標誌	TBP
Pfam	PF00352
Pfam宗系	CL0407
InterPro	IPR000814
PROSITE	PDOC00303
SCOP	1tbp / SUPFAM
現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

TATA结合蛋白
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1TGH、1C9B、1JFI、1NVP、4ROC、4ROE、4ROD、5IY9、5IYA、5FUR、5IYC、5IYB、5IY7、5IY8、5IYD、5IY6
識別號
别名	TBP；, GTF2D, GTF2D1, HDL4, SCA17, TFIID, TATA-box binding protein, TATA-binding protein
外部ID	OMIM：600075 MGI：101838 HomoloGene：2404 GeneCards：TBP
相關疾病
	spinocerebellar ataxia type 17[1]
基因位置（人类）
染色体	6號染色體[2]
终止	170,572,870 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • DNA结合转录因子活性; • 转录因子结合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • 血浆蛋白结合; • RNA polymerase II repressing transcription factor binding; • 酶结合; • repressing transcription factor binding; • TFIIB-class transcription factor binding; • aryl hydrocarbon receptor binding; • 核心启动子近端区域序列特异性DNA结合; • DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, core RNA polymerase III binding; • RNA polymerase II general transcription initiation factor activity; • RNA polymerase II core promoter sequence-specific DNA binding; • RNA polymerase III regulatory region DNA binding;
細胞組分	• 細胞質; • nuclear euchromatin; • transcription factor TFIID complex; • male pronucleus; • female pronucleus; • 核质; • transcription factor TFIIA complex; • pronucleus; • nuclear chromatin; • 细胞核; • transcriptional preinitiation complex; • 大分子复合体; • transcription factor TFIIIB complex; • 轉錄調節複合物;
生物學過程	• termination of RNA polymerase I transcription; • positive regulation of gene expression, epigenetic; • regulation of transcription, DNA-templated; • transcription initiation from RNA polymerase I promoter; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • 精子发生; • DNA-templated transcription, initiation; • transcription initiation from RNA polymerase II promoter; • snRNA transcription from RNA polymerase II promoter; • regulation of signal transduction by p53 class mediator; • viral process; • regulation of transcription from RNA polymerase III promoter; • transcription from RNA polymerase II promoter; • transcription from RNA polymerase III promoter; • RNA polymerase II transcriptional preinitiation complex assembly; • regulation of transcription from RNA polymerase II promoter; • RNA polymerase III transcriptional preinitiation complex assembly; • transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
直系同源
	6908
	21374
	ENSG00000112592
	ENSMUSG00000014767
	P20226
	P29037
	NM_003194; NM_001172085
	NM_013684
	NP_001165556; NP_003185
	NP_038712
	維基數據

TATA结合蛋白质（英語：，TBP）是一种通用转录因子，具体结合于DNA序列上的TATA盒。TATA盒位于真核基因的转录起始位点上游约30个bp，属于啟動子区[5]。TBP可以和各个TBP相关因子共同组成通用转录因子TF_IID,再进一步组成RNA聚合酶Ⅱ的转录起始复合物[6]。

蛋白质的相互作用

TATA结合蛋白与下列蛋白質进行互作：

BRF1,[7][8]
BTAF1,[9][10]
C-Fos,[11]
C-jun,[12]
EDF1,[13][14][15]
GTF2B (TFIIB),[16][17]
GTF2A1 (TFIIA subunit 1),[16][18][19][20]
GTF2F1 (TFIIF subunit 1)[9][21][22]
GTF2H4 (TFIIH subunit 4),[9]
Mdm2,[23][23][24]
MSX1,[25][26][27]
NFYB,[28]
P53,[29][30]
PAX6,[30]
POLR2A,[9]
POU2F1,[31]
RELA,[32][33]
NR2B1,[34]
TAF1,[28][35][36][37]
TAF4,[38]
TAF5,[28][36][39]
TAF6,[28][36][38]
TAF7,[28][38]
TAF9.[28][40]
TAF10,[28][36]
TAF11,[28][41][42]
TAF13,[41]
TAF15.[43]

参考文献

.
GRCh38: Ensembl release 89: ENSG00000112592 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (32): 12955–61. PMC 1941834. PMID 17670940. doi:10.1073/pnas.0704138104.
. Annu. Rev. Genet. 2000, 34: 77–137. PMID 11092823. doi:10.1146/annurev.genet.34.1.77.
McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM. . EMBO J. August 2000, 19 (15): 4134–43. PMC 306597. PMID 10921893. doi:10.1093/emboj/19.15.4134.
Wang Z, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. July 1995, 92 (15): 7026–30. PMC 41464. PMID 7624363. doi:10.1073/pnas.92.15.7026.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. . Proc. Natl. Acad. Sci. U.S.A. May 1997, 94 (11): 5605–10. PMC 20825. PMID 9159119. doi:10.1073/pnas.94.11.5605.
Chicca JJ, Auble DT, Pugh BF. . Mol. Cell. Biol. March 1998, 18 (3): 1701–10. PMC 108885. PMID 9488487.
Metz R, Bannister AJ, Sutherland JA, Hagemeier C, O'Rourke EC, Cook A, Bravo R, Kouzarides T. . Mol. Cell. Biol. September 1994, 14 (9): 6021–9. PMC 359128. PMID 8065335. doi:10.1128/MCB.14.9.6021.
Franklin CC, McCulloch AV, Kraft AS. . Biochem. J. February 1995, 305 (3): 967–74. PMC 1136352. PMID 7848298. doi:10.1042/bj3050967.
Brendel C, Gelman L, Auwerx J. . Mol. Endocrinol. June 2002, 16 (6): 1367–77. PMID 12040021. doi:10.1210/mend.16.6.0843.
Mariotti M, De Benedictis L, Avon E, Maier JA. . J. Biol. Chem. August 2000, 275 (31): 24047–51. PMID 10816571. doi:10.1074/jbc.M001928200.
Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H. . J. Biol. Chem. November 1999, 274 (48): 34196–202. PMID 10567391. doi:10.1074/jbc.274.48.34196.
Tang H, Sun X, Reinberg D, Ebright RH. . Proc. Natl. Acad. Sci. U.S.A. February 1996, 93 (3): 1119–24. PMC 40041. PMID 8577725. doi:10.1073/pnas.93.3.1119.
Bushnell DA, Westover KD, Davis RE, Kornberg RD. . Science. February 2004, 303 (5660): 983–8. PMID 14963322. doi:10.1126/science.1090838.
DeJong J, Bernstein R, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. April 1995, 92 (8): 3313–7. PMC 42156. PMID 7724559. doi:10.1073/pnas.92.8.3313.
Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM. . J. Biol. Chem. June 1998, 273 (23): 14293–300. PMID 9603936. doi:10.1074/jbc.273.23.14293.
Sun X, Ma D, Sheldon M, Yeung K, Reinberg D. . Genes Dev. October 1994, 8 (19): 2336–48. PMID 7958900. doi:10.1101/gad.8.19.2336.
Ruppert S, Tjian R. . Genes Dev. November 1995, 9 (22): 2747–55. PMID 7590250. doi:10.1101/gad.9.22.2747.
Malik S, Guermah M, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. March 1998, 95 (5): 2192–7. PMC 19292. PMID 9482861. doi:10.1073/pnas.95.5.2192.
Thut CJ, Goodrich JA, Tjian R. . Genes Dev. August 1997, 11 (15): 1974–86. PMC 316412. PMID 9271120. doi:10.1101/gad.11.15.1974.
Léveillard T, Wasylyk B. . J. Biol. Chem. December 1997, 272 (49): 30651–61. PMID 9388200. doi:10.1074/jbc.272.49.30651.
Shetty S, Takahashi T, Matsui H, Ayengar R, Raghow R. . Biochem. J. May 1999, 339 (3): 751–8. PMC 1220213. PMID 10215616. doi:10.1042/0264-6021:3390751.
Zhang H, Hu G, Wang H, Sciavolino P, Iler N, Shen MM, Abate-Shen C. . Mol. Cell. Biol. May 1997, 17 (5): 2920–32. PMC 232144. PMID 9111364. doi:10.1128/mcb.17.5.2920.
Zhang H, Catron KM, Abate-Shen C. . Proc. Natl. Acad. Sci. U.S.A. March 1996, 93 (5): 1764–9. PMC 39855. PMID 8700832. doi:10.1073/pnas.93.5.1764.
Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R. . Nucleic Acids Res. June 1997, 25 (11): 2174–81. PMC 146709. PMID 9153318. doi:10.1093/nar/25.11.2174.
Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T. . Proc. Natl. Acad. Sci. U.S.A. December 1992, 89 (24): 12028–32. PMC 50691. PMID 1465435. doi:10.1073/pnas.89.24.12028.
Cvekl A, Kashanchi F, Brady JN, Piatigorsky J. . Invest. Ophthalmol. Vis. Sci. June 1999, 40 (7): 1343–50. PMID 10359315.
Zwilling S, Annweiler A, Wirth T. . Nucleic Acids Res. May 1994, 22 (9): 1655–62. PMC 308045. PMID 8202368. doi:10.1093/nar/22.9.1655.
Guermah M, Malik S, Roeder RG. . Mol. Cell. Biol. June 1998, 18 (6): 3234–44. PMC 108905. PMID 9584164. doi:10.1128/mcb.18.6.3234.
Schmitz ML, Stelzer G, Altmann H, Meisterernst M, Baeuerle PA. . J. Biol. Chem. March 1995, 270 (13): 7219–26. PMID 7706261. doi:10.1074/jbc.270.13.7219.
Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM. . Proc. Natl. Acad. Sci. U.S.A. August 1995, 92 (18): 8288–92. PMC 41142. PMID 7667283. doi:10.1073/pnas.92.18.8288.
Siegert JL, Robbins PD. . Mol. Cell. Biol. January 1999, 19 (1): 846–54. PMC 83941. PMID 9858607.
Ruppert S, Wang EH, Tjian R. . Nature. March 1993, 362 (6416): 175–9. PMID 7680771. doi:10.1038/362175a0.
O'Brien T, Tjian R. . Mol. Cell. May 1998, 1 (6): 905–11. PMID 9660973. doi:10.1016/S1097-2765(00)80089-1.
Pointud JC, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone-Corsi P, Davidson I. . J. Cell. Sci. May 2003, 116 (Pt 9): 1847–58. PMID 12665565. doi:10.1242/jcs.00391.
Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG. . J. Biol. Chem. March 1997, 272 (10): 6714–21. PMID 9045704. doi:10.1074/jbc.272.10.6714.
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG. . Mol. Cell. Biol. October 2001, 21 (20): 6782–95. PMC 99856. PMID 11564863. doi:10.1128/MCB.21.20.6782-6795.2001.
Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I. . EMBO J. April 1995, 14 (7): 1520–31. PMC 398239. PMID 7729427.
May M, Mengus G, Lavigne AC, Chambon P, Davidson I. . EMBO J. June 1996, 15 (12): 3093–104. PMC 450252. PMID 8670810.
Hoffmann A, Roeder RG. . J. Biol. Chem. July 1996, 271 (30): 18194–202. PMID 8663456. doi:10.1074/jbc.271.30.18194.

外部链接

GeneReviews/NCBI/国家卫生研究院/大学进入脊髓小脑失调类型17 页面存档备份，存于
交互式TBP结构在梅西。ac.新西兰
每月PDB分子主題TATA-binding protein
MeSH（醫學主題詞）上面的TATA-Box+Binding+Protein（美式英语）
FactorBook TBP

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000112592 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17670940-5] . Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (32): 12955–61. PMC 1941834. PMID 17670940. doi:10.1073/pnas.0704138104.

[pmid11092823-6] . Annu. Rev. Genet. 2000, 34: 77–137. PMID 11092823. doi:10.1146/annurev.genet.34.1.77.

[pmid10921893-7] McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM. . EMBO J. August 2000, 19 (15): 4134–43. PMC 306597. PMID 10921893. doi:10.1093/emboj/19.15.4134.

[pmid7624363-8] Wang Z, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. July 1995, 92 (15): 7026–30. PMC 41464. PMID 7624363. doi:10.1073/pnas.92.15.7026.

[pmid9159119-9] Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. . Proc. Natl. Acad. Sci. U.S.A. May 1997, 94 (11): 5605–10. PMC 20825. PMID 9159119. doi:10.1073/pnas.94.11.5605.

[pmid9488487-10] Chicca JJ, Auble DT, Pugh BF. . Mol. Cell. Biol. March 1998, 18 (3): 1701–10. PMC 108885. PMID 9488487.

[pmid8065335-11] Metz R, Bannister AJ, Sutherland JA, Hagemeier C, O'Rourke EC, Cook A, Bravo R, Kouzarides T. . Mol. Cell. Biol. September 1994, 14 (9): 6021–9. PMC 359128. PMID 8065335. doi:10.1128/MCB.14.9.6021.

[pmid7848298-12] Franklin CC, McCulloch AV, Kraft AS. . Biochem. J. February 1995, 305 (3): 967–74. PMC 1136352. PMID 7848298. doi:10.1042/bj3050967.

[pmid12040021-13] Brendel C, Gelman L, Auwerx J. . Mol. Endocrinol. June 2002, 16 (6): 1367–77. PMID 12040021. doi:10.1210/mend.16.6.0843.

[pmid10816571-14] Mariotti M, De Benedictis L, Avon E, Maier JA. . J. Biol. Chem. August 2000, 275 (31): 24047–51. PMID 10816571. doi:10.1074/jbc.M001928200.

[pmid10567391-15] Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H. . J. Biol. Chem. November 1999, 274 (48): 34196–202. PMID 10567391. doi:10.1074/jbc.274.48.34196.

[Tang-16] Tang H, Sun X, Reinberg D, Ebright RH. . Proc. Natl. Acad. Sci. U.S.A. February 1996, 93 (3): 1119–24. PMC 40041. PMID 8577725. doi:10.1073/pnas.93.3.1119.

[pmid14963322-17] Bushnell DA, Westover KD, Davis RE, Kornberg RD. . Science. February 2004, 303 (5660): 983–8. PMID 14963322. doi:10.1126/science.1090838.

[pmid7724559-18] DeJong J, Bernstein R, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. April 1995, 92 (8): 3313–7. PMC 42156. PMID 7724559. doi:10.1073/pnas.92.8.3313.

[pmid9603936-19] Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM. . J. Biol. Chem. June 1998, 273 (23): 14293–300. PMID 9603936. doi:10.1074/jbc.273.23.14293.

[pmid7958900-20] Sun X, Ma D, Sheldon M, Yeung K, Reinberg D. . Genes Dev. October 1994, 8 (19): 2336–48. PMID 7958900. doi:10.1101/gad.8.19.2336.

[pmid7590250-21] Ruppert S, Tjian R. . Genes Dev. November 1995, 9 (22): 2747–55. PMID 7590250. doi:10.1101/gad.9.22.2747.

[pmid9482861-22] Malik S, Guermah M, Roeder RG. . Proc. Natl. Acad. Sci. U.S.A. March 1998, 95 (5): 2192–7. PMC 19292. PMID 9482861. doi:10.1073/pnas.95.5.2192.

[pmid9271120-23] Thut CJ, Goodrich JA, Tjian R. . Genes Dev. August 1997, 11 (15): 1974–86. PMC 316412. PMID 9271120. doi:10.1101/gad.11.15.1974.

[pmid9388200-24] Léveillard T, Wasylyk B. . J. Biol. Chem. December 1997, 272 (49): 30651–61. PMID 9388200. doi:10.1074/jbc.272.49.30651.

[pmid10215616-25] Shetty S, Takahashi T, Matsui H, Ayengar R, Raghow R. . Biochem. J. May 1999, 339 (3): 751–8. PMC 1220213. PMID 10215616. doi:10.1042/0264-6021:3390751.

[pmid9111364-26] Zhang H, Hu G, Wang H, Sciavolino P, Iler N, Shen MM, Abate-Shen C. . Mol. Cell. Biol. May 1997, 17 (5): 2920–32. PMC 232144. PMID 9111364. doi:10.1128/mcb.17.5.2920.

[pmid8700832-27] Zhang H, Catron KM, Abate-Shen C. . Proc. Natl. Acad. Sci. U.S.A. March 1996, 93 (5): 1764–9. PMC 39855. PMID 8700832. doi:10.1073/pnas.93.5.1764.

[pmid9153318-28] Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R. . Nucleic Acids Res. June 1997, 25 (11): 2174–81. PMC 146709. PMID 9153318. doi:10.1093/nar/25.11.2174.

[pmid1465435-29] Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T. . Proc. Natl. Acad. Sci. U.S.A. December 1992, 89 (24): 12028–32. PMC 50691. PMID 1465435. doi:10.1073/pnas.89.24.12028.

[pmid10359315-30] Cvekl A, Kashanchi F, Brady JN, Piatigorsky J. . Invest. Ophthalmol. Vis. Sci. June 1999, 40 (7): 1343–50. PMID 10359315.

[pmid8202368-31] Zwilling S, Annweiler A, Wirth T. . Nucleic Acids Res. May 1994, 22 (9): 1655–62. PMC 308045. PMID 8202368. doi:10.1093/nar/22.9.1655.

[pmid9584164-32] Guermah M, Malik S, Roeder RG. . Mol. Cell. Biol. June 1998, 18 (6): 3234–44. PMC 108905. PMID 9584164. doi:10.1128/mcb.18.6.3234.

[pmid7706261-33] Schmitz ML, Stelzer G, Altmann H, Meisterernst M, Baeuerle PA. . J. Biol. Chem. March 1995, 270 (13): 7219–26. PMID 7706261. doi:10.1074/jbc.270.13.7219.

[pmid7667283-34] Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM. . Proc. Natl. Acad. Sci. U.S.A. August 1995, 92 (18): 8288–92. PMC 41142. PMID 7667283. doi:10.1073/pnas.92.18.8288.

[pmid9858607-35] Siegert JL, Robbins PD. . Mol. Cell. Biol. January 1999, 19 (1): 846–54. PMC 83941. PMID 9858607.

[pmid7680771-36] Ruppert S, Wang EH, Tjian R. . Nature. March 1993, 362 (6416): 175–9. PMID 7680771. doi:10.1038/362175a0.

[pmid9660973-37] O'Brien T, Tjian R. . Mol. Cell. May 1998, 1 (6): 905–11. PMID 9660973. doi:10.1016/S1097-2765(00)80089-1.

[pmid12665565-38] Pointud JC, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone-Corsi P, Davidson I. . J. Cell. Sci. May 2003, 116 (Pt 9): 1847–58. PMID 12665565. doi:10.1242/jcs.00391.

[pmid9045704-39] Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG. . J. Biol. Chem. March 1997, 272 (10): 6714–21. PMID 9045704. doi:10.1074/jbc.272.10.6714.

[pmid11564863-40] Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG. . Mol. Cell. Biol. October 2001, 21 (20): 6782–95. PMC 99856. PMID 11564863. doi:10.1128/MCB.21.20.6782-6795.2001.

[pmid7729427-41] Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I. . EMBO J. April 1995, 14 (7): 1520–31. PMC 398239. PMID 7729427.

[pmid8670810-42] May M, Mengus G, Lavigne AC, Chambon P, Davidson I. . EMBO J. June 1996, 15 (12): 3093–104. PMC 450252. PMID 8670810.

[pmid8663456-43] Hoffmann A, Roeder RG. . J. Biol. Chem. July 1996, 271 (30): 18194–202. PMID 8663456. doi:10.1074/jbc.271.30.18194.