內輸蛋白亞基α-2

內輸蛋白亞基α-2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1EFX、1QGK、1QGR、3FEX、3FEY、3WPT、4E4V、4WV6
識別號
别名	KPNA2；, IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2
外部ID	OMIM：600685 MGI：103561 HomoloGene：1708 GeneCards：KPNA2
基因位置（人类）
染色体	染色体17（人类）[1]
终止	68,046,854 bp[1]
基因位置（小鼠）
染色体	染色体11（小鼠）[2]
终止	106,999,541 bp[2]
基因本體
分子功能	• histone deacetylase binding; • 血浆蛋白结合; • nuclear localization sequence binding; • RNA binding; • nuclear import signal receptor activity;
細胞組分	• 膜; • 核孔; • 核质; • 细胞核; • 細胞質; • 细胞质基质; • host cell; • extrinsic component of postsynaptic specialization membrane; • glutamatergic synapse;
生物學過程	• regulation of DNA recombination; • protein import into nucleus; • DNA代谢过程; • protein transport; • viral process; • NLS-bearing protein import into nucleus; • modulation by virus of host process; • intracellular transport of virus; • transport; • postsynapse to nucleus signaling pathway; • entry of viral genome into host nucleus through nuclear pore complex via importin; • positive regulation of viral life cycle;
	Sources:Amigo / QuickGO
直系同源
	3838
	16647
	ENSG00000182481
	ENSMUSG00000018362
	P52292
	P52293
	NM_002266、NM_001320611
	NM_010655
	NP_001307540、NP_002257
	NP_034785
	維基數據

內輸蛋白亞基α-2（英語：）是人體內的一種蛋白質，為內輸蛋白α的一種，由17號染色體上的KPNA2基因編碼。[5][6]

功能

內輸蛋白亞基α-2參與了蛋白質由細胞質轉運進細胞核的過程，細胞質中，內輸蛋白α可結合具有核定位序列的蛋白質[7]，接著再與內輸蛋白β結合而形成二聚體，後者可與核孔複合物互動，使二聚體和蛋白質一起進入細胞核中。入核後，內輸蛋白二聚體與Ran-GTP結合而將原本結合的蛋白質釋出，再回到細胞質中。此過程與Ran循環偶連，並需消耗能量[8]。

除了協助蛋白質進入細胞核外，KPNA2可能也參與V(D)J重組[9]。

交互作用

核轉運蛋白α-2會與以下的蛋白質產生交互作用：

ADP-核糖基化因子樣蛋白4A[10]
白細胞介素-2誘導性T細胞激酶[11]
內輸蛋白亞基b-1[12][13][14]
鋅指蛋白PLAG1[15]
ATP依賴性DNA螺旋酶Q1[16]
絲氨酸/蘇氨酸蛋白激酶[17]

參考文獻

GRCh38: Ensembl release 89: ENSG00000182481 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. . Proceedings of the National Academy of Sciences of the United States of America. Jun 1994, 91 (13): 6156–60. PMC 44157. PMID 8016130. doi:10.1073/pnas.91.13.6156.
Weis K, Mattaj IW, Lamond AI. . Science. May 1995, 268 (5213): 1049–53. PMID 7754385. doi:10.1126/science.7754385.
Moroianu, J; Blobel, G; Radu, A. . Proceedings of the National Academy of Sciences of the United States of America. 1995-03-14, 92 (6): 2008–2011. ISSN 0027-8424. PMC 42412. PMID 7892216. doi:10.1073/pnas.92.6.2008.
Goldfarb, David S.; Corbett, Anita H.; Mason, D. Adam; Harreman, Michelle T.; Adam, Stephen A. . Trends in Cell Biology. 2004, 14 (9): 505–514. PMID 15350979. doi:10.1016/j.tcb.2004.07.016.
. （原始内容存档于2010-12-05）.
Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ. . The Journal of Biological Chemistry. Dec 2000, 275 (48): 37815–23. PMID 10980193. doi:10.1074/jbc.M002470200.
Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. . International Immunology. Oct 2001, 13 (10): 1265–74. PMID 11581171. doi:10.1093/intimm/13.10.1265.
Nagoshi E, Yoneda Y. . Molecular and Cellular Biology. Apr 2001, 21 (8): 2779–89. PMC 86908. PMID 11283257. doi:10.1128/MCB.21.8.2779-2789.2001.
Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E. . Molecular and Cellular Biology. Nov 1999, 19 (11): 7782–91. PMC 84838. PMID 10523667. doi:10.1128/mcb.19.11.7782.
Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D. . Cell. Sep 1997, 90 (6): 1061–71. PMID 9323134. doi:10.1016/s0092-8674(00)80372-4.
Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML. . The Journal of Biological Chemistry. May 2002, 277 (22): 19673–8. PMID 11882654. doi:10.1074/jbc.M112112200.
Seki T, Tada S, Katada T, Enomoto T. . Biochemical and Biophysical Research Communications. May 1997, 234 (1): 48–53. PMID 9168958. doi:10.1006/bbrc.1997.6535.
Maiyar AC, Leong ML, Firestone GL. . Molecular Biology of the Cell. Mar 2003, 14 (3): 1221–39. PMC 151592. PMID 12631736. doi:10.1091/mbc.E02-03-0170.

延伸閱讀

Bukrinsky MI, Haffar OK. . Frontiers in Bioscience. Dec 1997, 2 (4): d578–87. PMID 9366553. doi:10.2741/A213.
Bukrinsky MI, Haffar OK. . Molecular Medicine. Mar 1998, 4 (3): 138–43. PMC 2230352. PMID 9562972. doi:10.1007/BF03401911.
Kino T, Pavlakis GN. . DNA and Cell Biology. Apr 2004, 23 (4): 193–205 [2019-07-18]. PMID 15142377. doi:10.1089/104454904773819789. （原始内容存档于2020-11-07）.
Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L. . Journal of Molecular Histology. Sep 2006, 37 (5–7): 293–9. PMID 16752129. doi:10.1007/s10735-006-9032-y.
Bukrinsky MI, Sharova N, Dempsey MP, Stanwick TL, Bukrinskaya AG, Haggerty S, Stevenson M. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1992, 89 (14): 6580–4. PMC 49545. PMID 1631159. doi:10.1073/pnas.89.14.6580.
Sharova N, Bukrinskaya A. . AIDS Research and Human Retroviruses. Mar 1991, 7 (3): 303–6. PMID 2064827. doi:10.1089/aid.1991.7.303.
Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR. . Journal of Virology. Dec 1995, 69 (12): 7909–16. PMC 189735. PMID 7494303.
Küssel P, Frasch M. . Molecular & General Genetics. Aug 1995, 248 (3): 351–63. PMID 7565597. doi:10.1007/BF02191602.
Gallay P, Swingler S, Song J, Bushman F, Trono D. . Cell. Nov 1995, 83 (4): 569–76. PMID 7585960. doi:10.1016/0092-8674(95)90097-7.
Moroianu J, Hijikata M, Blobel G, Radu A. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1995, 92 (14): 6532–6. PMC 41552. PMID 7604027. doi:10.1073/pnas.92.14.6532.
Freed EO, Englund G, Martin MA. . Journal of Virology. Jun 1995, 69 (6): 3949–54. PMC 189124. PMID 7745752.
Gallay P, Swingler S, Aiken C, Trono D. . Cell. Feb 1995, 80 (3): 379–88. PMID 7859280. doi:10.1016/0092-8674(95)90488-3.
von Schwedler U, Kornbluth RS, Trono D. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (15): 6992–6. PMC 44324. PMID 8041734. doi:10.1073/pnas.91.15.6992.
Heinzinger NK, Bukrinsky MI, Haggerty SA, Ragland AM, Kewalramani V, Lee MA, Gendelman HE, Ratner L, Stevenson M, Emerman M. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (15): 7311–5. PMC 44389. PMID 8041786. doi:10.1073/pnas.91.15.7311.
Bukrinsky MI, Haggerty S, Dempsey MP, Sharova N, Adzhubel A, Spitz L, Lewis P, Goldfarb D, Emerman M, Stevenson M. . Nature. Oct 1993, 365 (6447): 666–9. PMID 8105392. doi:10.1038/365666a0.
Dubrovsky L, Ulrich P, Nuovo GJ, Manogue KR, Cerami A, Bukrinsky M. . Molecular Medicine. Jan 1995, 1 (2): 217–30. PMC 2229944. PMID 8529100. doi:10.1007/BF03401569.
Gallay P, Stitt V, Mundy C, Oettinger M, Trono D. . Journal of Virology. Feb 1996, 70 (2): 1027–32. PMC 189908. PMID 8551560.
Bukrinskaya AG, Ghorpade A, Heinzinger NK, Smithgall TE, Lewis RE, Stevenson M. . Proceedings of the National Academy of Sciences of the United States of America. Jan 1996, 93 (1): 367–71. PMC 40239. PMID 8552640. doi:10.1073/pnas.93.1.367.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182481 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8016130-5] Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. . Proceedings of the National Academy of Sciences of the United States of America. Jun 1994, 91 (13): 6156–60. PMC 44157. PMID 8016130. doi:10.1073/pnas.91.13.6156.

[pmid7754385-6] Weis K, Mattaj IW, Lamond AI. . Science. May 1995, 268 (5213): 1049–53. PMID 7754385. doi:10.1126/science.7754385.

[7] Moroianu, J; Blobel, G; Radu, A. . Proceedings of the National Academy of Sciences of the United States of America. 1995-03-14, 92 (6): 2008–2011. ISSN 0027-8424. PMC 42412. PMID 7892216. doi:10.1073/pnas.92.6.2008.

[8] Goldfarb, David S.; Corbett, Anita H.; Mason, D. Adam; Harreman, Michelle T.; Adam, Stephen A. . Trends in Cell Biology. 2004, 14 (9): 505–514. PMID 15350979. doi:10.1016/j.tcb.2004.07.016.

[entrez-9] . （原始内容存档于2010-12-05）.

[pmid10980193-10] Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ. . The Journal of Biological Chemistry. Dec 2000, 275 (48): 37815–23. PMID 10980193. doi:10.1074/jbc.M002470200.

[pmid11581171-11] Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. . International Immunology. Oct 2001, 13 (10): 1265–74. PMID 11581171. doi:10.1093/intimm/13.10.1265.

[pmid11283257-12] Nagoshi E, Yoneda Y. . Molecular and Cellular Biology. Apr 2001, 21 (8): 2779–89. PMC 86908. PMID 11283257. doi:10.1128/MCB.21.8.2779-2789.2001.

[pmid10523667-13] Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E. . Molecular and Cellular Biology. Nov 1999, 19 (11): 7782–91. PMC 84838. PMID 10523667. doi:10.1128/mcb.19.11.7782.

[pmid9323134-14] Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D. . Cell. Sep 1997, 90 (6): 1061–71. PMID 9323134. doi:10.1016/s0092-8674(00)80372-4.

[pmid11882654-15] Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML. . The Journal of Biological Chemistry. May 2002, 277 (22): 19673–8. PMID 11882654. doi:10.1074/jbc.M112112200.

[pmid9168958-16] Seki T, Tada S, Katada T, Enomoto T. . Biochemical and Biophysical Research Communications. May 1997, 234 (1): 48–53. PMID 9168958. doi:10.1006/bbrc.1997.6535.

[pmid12631736-17] Maiyar AC, Leong ML, Firestone GL. . Molecular Biology of the Cell. Mar 2003, 14 (3): 1221–39. PMC 151592. PMID 12631736. doi:10.1091/mbc.E02-03-0170.