别孕烷醇酮

**别孕烷醇酮**
系统（IUPAC）命名名称
	1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone; OR; 1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-14-yl]ethanone
临床数据
商品名	Zulresso
给药途径	Intravenous infusion[1]
合法狀態
合法状态	US: 处方药（℞-only） ;
药代动力学数据
蛋白结合度	>99%[1]
代谢	Non-CYP450 (keto-reduction via AKRs, glucuronidation via UGTs, sulfation via SULTs)[1]
生物半衰期	9 hours[1]
排泄	Feces: 47%[1]; Urine: 42%[1]
识别
CAS注册号	516-54-1
PubChem	CID 92786
DrugBank	DB11859
ChemSpider	83760
UNII	S39XZ5QV8Y
KEGG	D11149
ChEBI	CHEBI:50169
ChEMBL	CHEMBL207538
其他名称	ALLO; Allo; ALLOP; AlloP; Brexanolone; SAGE-547; SGE-102; 5α-Pregnan-3α-ol-20-one; 3α-Hydroxy-5α-pregnan-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP
化学
化学式	C21H34O2
摩尔质量	318.501 g/mol
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C;
	InChI InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1; Key:AURFZBICLPNKBZ-SYBPFIFISA-N;

别孕烷醇酮（英語：，ALLO，也名为3α,5α-孕烷醇酮）是一种作用于大脑的神经甾体[2][3]，可用于治疗产后抑郁症[3][4][5]。

参考文献

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