异炔诺酮

异炔诺酮英語:英語:商品名:Enovid等)是一种黄体制剂药物,过去被用于口服避孕药以及治疗一些妇科疾病,但现在已不再使用[2][6][7][8]。异炔诺酮和炔诺酮的不同之处在于双键位于5(10)号位而非4(5)号位。

异炔诺酮
系统(IUPAC)命名名称
(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
临床数据
商品名Enovid (with mestranol), others
给药途径口服给药
药代动力学数据
蛋白结合度Noretynodrel:至albumin and not至SHBG or CBG[1]
代谢Liver, intestines (hydroxylation, isomerization, conjugation)[1][2]
代謝產物• 3α-Hydroxynoretynodrel[3]
• 3β-Hydroxynoretynodrel[3]
Norethisterone[3][1][2]
Ethinylestradiol[2][4]Conjugates[2]
生物半衰期Very short (< 30 minutes)[5]
排泄Breast milk: 1%[6]
识别
CAS注册号68-23-5  
ATC代码G03FA09
PubChemCID 6231
DrugBankDB09371 
ChemSpider5995 
UNII88181ACA0M 
KEGGD05207
ChEBICHEBI:34895 
ChEMBLCHEMBL1387 
其他名称Norethynodrel; Noretinodrel Norethinodrel; NYD; SC-4642; NSC-15432; 5(10)-Norethisterone; 17α-Ethinyl-19-nor-5(10)-testosterone; 17α-Ethynyl-δ5(10)-19-nortestosterone; 17α-Ethynylestr-5(10)-en-17β-ol-3-one; 19-Nor-17α-pregn-5(10)-en-20-yn-17β-ol-3-one
化学
化学式C20H26O2
摩尔质量298.419 g/mol

参考文献

  1. Kuhl H. . Maturitas. September 1990, 12 (3): 171–97. PMID 2170822. doi:10.1016/0378-5122(90)90003-O.
  2. Kuhl H. (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63. PMID 16112947. doi:10.1080/13697130500148875.
  3. Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. . J. Steroid Biochem. Mol. Biol. 2012, 129 (3–5): 139–44. PMC 3303946. PMID 22210085. doi:10.1016/j.jsbmb.2011.12.002.
  4. Kuhl H. (PDF). J Reproduktionsmed Endokrinol. 2011, 8 (1): 157–177.
  5. Hammerstein J. . Am. J. Obstet. Gynecol. 1990, 163 (6 Pt 2): 2198–203. PMID 2256526.
  6. Sweetman, Sean C. (编). . 36th. London: Pharmaceutical Press. 2009: 2120–2121. ISBN 978-0-85369-840-1.
  7. Jucker. . Birkhäuser. 21 December 2013: 85–88. ISBN 978-3-0348-7065-8.
  8. Lara Marks. . Yale University Press. 2010: 74–75. ISBN 978-0-300-16791-7.
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