替莫唑胺
帝盟多是一种口服化疗药物(屬於烷基化剂),用于治疗某些脑癌,如成人恶性神经胶质瘤和恶性黑色素瘤。该药物由英國伯明翰阿斯顿大学的教授马尔寇姆史蒂文斯帶領的团队研發成功。[1][2][3]它自1999年8月在美国上市以来便可购得,2000年以後開始在其他国家上市。
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系统(IUPAC)命名名称 | |
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4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide | |
临床数据 | |
商品名 | Temodar, Temodal, Temcad |
Drugs.com | Monograph |
MedlinePlus | a601250 |
医疗法规 |
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妊娠分级 |
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给药途径 | Oral, intravenous |
合法狀態 | |
合法状态 |
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药代动力学数据 | |
蛋白结合度 | 15% |
代谢 | spontaneously hydrolyzed at physiologic pH至the active species, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) and至temozolomide acid metabolite |
生物半衰期 | 1.8 hours |
识别 | |
CAS注册号 | 85622-93-1 ![]() |
ATC代码 | L01AX03 |
PubChem | CID 5394 |
IUPHAR/BPS | 7301 |
DrugBank | DB00853 ![]() |
ChemSpider | 5201 ![]() |
UNII | YF1K15M17Y ![]() |
KEGG | D06067 ![]() |
ChEBI | CHEBI:72564 ![]() |
ChEMBL | CHEMBL810 ![]() |
化学 | |
化学式 | C6H6N6O2 |
摩尔质量 | 194.151 g/mol |
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物理性质 | |
熔点 | 212 °C(414 °F) (分解) |
藥物合成
![](../I/Temozolomide_Synthesis.svg.png.webp)
参考文献
- Sansom C. (PDF). Chemistry World. July 2009: 48–51.
- . Cancer Research UK impact & achievements page. (原始内容存档于14 March 2012).
- Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. . Cancer Treatment Reviews. January 1997, 23 (1): 35–61. PMID 9189180. doi:10.1016/S0305-7372(97)90019-0.
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