特發性間質性肺炎

特發性間質性肺炎; Idiopathic interstitial pneumonia
	Micrograph of usual interstitial pneumonia (UIP). UIP is the most common pattern of idiopathic interstitial pneumonia and usually represents 特发性肺纤维化. 苏木精-伊红染色. 驗屍 specimen.
症状	肺炎
类型	肺炎, 間質性肺病, 特發性
分类和外部资源
醫學專科	胸腔醫學
Orphanet	98300

特發性間質肺炎（Idiopathic interstitial pneumonia，簡稱IIP），又稱非感染性肺炎（noninfectious pneumonia）[1]，屬於一種間質性肺病。該疾病通常侵襲肺間質，有些也會侵襲氣道（例如Cryptogenic organizing pneumonitis），IIP可分為七個亞型。

組織學分類

IIP的分類相當複雜[2]，須結合臨床觀察、影像學，以及病理学[3][4]才能確診。

特發性間質性肺炎可由組織學型態分為下列數種[5][6]：

組織學	臨床相關意義
Desquamative interstitial pneumonia (DIP)	DIP
Diffuse alveolar damage (DAD)	急性呼吸窘迫症候群、急性間質性肺炎、輸血相關急性肺損傷
非特異性間質性肺炎（NSIP）	NSIP
Respiratory bronchiolitis	呼吸性細支氣管相關之間質性肺病（RB-ILD）
尋常性間質性肺炎 (UIP)	自體免疫性疾病、特发性肺纤维化、致死量、肺塵病
Organizing pneumonia	隱源性機化性肺炎
淋巴樣間質性肺炎 (LIP)	LIP

其中尋常性間質性肺炎為最常見的一種亞型[7]。

發育

Table 1: Development of the (histologic) idiopathic interstitial pneumonia classification

Leibow et al. (1969)

Katzenstein (1998)[8]

ATS/ERS (2002)[6]

UIP

DAD

NSIP

DIP

DIP/RB

DIP

RB

BIP

OP

LIP

(LPD)

LIP

GIP

(HMF)

UIP=usual interstitial pneumonia; DAD=diffuse alveolar damage; NSIP=non-specific interstitial pneumonia; DIP=desquamative interstitial pneumonia; RB=respiratory bronchiolitis; BIP=bronchiolitis obliterans interstitial pneumonia; OP=organizing pneumonia; LIP=lymphoid interstitial pneumonia; LPD=lymphoproliferative disease (not considered a diffuse lung disease); GIP=giant cell interstitial pneumonia; HMF=heavy metal fibrosis, no longer grouped with diffuse lung disease

Lymphoid interstitial pneumonia was originally included in this category, then excluded, then included again.[9]

參考文獻

. New York, NY [u.a.]: Oxford Univ. Press. 1999: 833. ISBN 978-0-19-508103-9. Authors list列表中的|first1=缺少|last1= (帮助)
Nicholson AG. . Histopathology. November 2002, 41 (5): 381–91. PMID 12405906. doi:10.1046/j.1365-2559.2002.01421.x.
Flaherty KR, King TE, Raghu G, 等. . Am. J. Respir. Crit. Care Med. October 2004, 170 (8): 904–10. PMID 15256390. doi:10.1164/rccm.200402-147OC.
Kim DS, Collard HR, King TE. . Proc Am Thorac Soc. June 2006, 3 (4): 285–92. PMC 2658683. PMID 16738191. doi:10.1513/pats.200601-005TK.
Leslie KO, Wick MR. Practical Pulmonary Pathology: A Diagnostic Approach. Elsevier Inc. 2005. ISBN 978-0-443-06631-3.
American Thoracic, Society; European Respiratory, Society. . Am. J. Respir. Crit. Care Med. January 2002, 165 (2): 277–304. PMID 11790668. doi:10.1164/ajrccm.165.2.ats01.
Visscher DW, Myers JL. . Proc Am Thorac Soc. June 2006, 3 (4): 322–9 [2016-05-15]. PMID 16738196. doi:10.1513/pats.200602-019TK. （原始内容存档于2019-12-11）.
Katzenstein AL, Myers JL. . Am. J. Respir. Crit. Care Med. 1998, 157 (4 Pt 1): 1301–15. PMID 9563754. doi:10.1164/ajrccm.157.4.9707039.
Swigris JJ, Berry GJ, Raffin TA, Kuschner WG. . Chest. December 2002, 122 (6): 2150–64. PMID 12475860. doi:10.1378/chest.122.6.2150.

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[1] . New York, NY [u.a.]: Oxford Univ. Press. 1999: 833. ISBN 978-0-19-508103-9. Authors list列表中的|first1=缺少|last1= (帮助)

[pmid12405906-2] Nicholson AG. . Histopathology. November 2002, 41 (5): 381–91. PMID 12405906. doi:10.1046/j.1365-2559.2002.01421.x.

[pmid15256390-3] Flaherty KR, King TE, Raghu G, 等. . Am. J. Respir. Crit. Care Med. October 2004, 170 (8): 904–10. PMID 15256390. doi:10.1164/rccm.200402-147OC.

[pmid16738191-4] Kim DS, Collard HR, King TE. . Proc Am Thorac Soc. June 2006, 3 (4): 285–92. PMC 2658683. PMID 16738191. doi:10.1513/pats.200601-005TK.

[5] Leslie KO, Wick MR. Practical Pulmonary Pathology: A Diagnostic Approach. Elsevier Inc. 2005. ISBN 978-0-443-06631-3.

[atsers-6] American Thoracic, Society; European Respiratory, Society. . Am. J. Respir. Crit. Care Med. January 2002, 165 (2): 277–304. PMID 11790668. doi:10.1164/ajrccm.165.2.ats01.

[pmid16738196-7] Visscher DW, Myers JL. . Proc Am Thorac Soc. June 2006, 3 (4): 322–9 [2016-05-15]. PMID 16738196. doi:10.1513/pats.200602-019TK. （原始内容存档于2019-12-11）.

[katzenstein-8] Katzenstein AL, Myers JL. . Am. J. Respir. Crit. Care Med. 1998, 157 (4 Pt 1): 1301–15. PMID 9563754. doi:10.1164/ajrccm.157.4.9707039.

[pmid12475860-9] Swigris JJ, Berry GJ, Raffin TA, Kuschner WG. . Chest. December 2002, 122 (6): 2150–64. PMID 12475860. doi:10.1378/chest.122.6.2150.