索普反应
Thorpe-Ziegler反应
二腈发生的分子内Thorpe反应也称作Thorpe-Ziegler反应(索普-齐格勒反应)。水解产物是α-氰基酮,继续水解得到β-酮酸,脱羧生成环酮。[3] 它是卡尔·齐格勒对Thorpe反应的改进,[4] 与二酯的Dieckmann缩合反应有些相似。
参考资料
- Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. J. Chem. Soc. 1904, 85, 1726.
- Schaefer, J. P.; Bloomfield, J. J. Org. React. 1967, 15, 1.(综述)
- Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link
- Karl Ziegler et al. Ann. 1933, 504, 94.
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