胆固醇侧链裂解酶

Cytochrome P450 family 11 subfamily A member 1
識別號
别名	；CYP11A1、CYPXIA1、Cholesterol desmolase、cholesterol 20-22 desmolase、cholesterol monooxygenase (side-chain cleaving)、cholesterol side-chain cleavage enzyme, mitochondrial、cytochrome P450 11A1、cytochrome P450 family 11 subfamily A polypeptide 1、cytochrome P450(scc)、cytochrome P450, subfamily XIA (cholesterol side chain cleavage)、steroid 20-22-lyase、胆固醇侧链裂解酶P450scc
外部ID	GeneCards：
RNA表达模式
	更多參考（基因）表达數據
直系同源
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	維基數據
檢視/編輯人類

胆固醇侧链裂解酶（英語：，CYP11A1或P450scc，其中“scc”是“side-chain 侧链”“cleavage 裂解”的缩写）是一种将胆固醇转化为孕烯醇酮的线粒体酶。这是所有哺乳动物中由胆固醇生成各种甾类激素的第一步反应[1]。

胆固醇 + 3 NADPH + 3 H⁺ + 3 O₂ ⇄ 孕烯醇酮 + 4-甲基戊醛 + 3 NADP⁺ + 3 H₂O

P450scc 是细胞色素P450氧化酶超家族的一员（家族11亚家族A多肽1），基因名为 CYP11A1[2]。

另见

参考文献

Hanukoglu I. . The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
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延伸阅读

Helmberg A. . Acta Endocrinologica. August 1993, 129 (2): 97–108. PMID 8372604. doi:10.1530/acta.0.1290097.
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K. . Steroids. January 1997, 62 (1): 21–8. PMID 9029710. doi:10.1016/S0039-128X(96)00154-7.
Stocco DM. . Biochimica et Biophysica Acta. June 2000, 1486 (1): 184–97. PMID 10856721. doi:10.1016/S1388-1981(00)00056-1.
Kristensen VN, Kure EH, Erikstein B, Harada N, Børresen-Dale A. . Mutation Research. October 2001, 482 (1–2): 77–82. PMID 11535251. doi:10.1016/S0027-5107(01)00212-3.
Strauss JF. . Annals of the New York Academy of Sciences. November 2003, 997 (1): 42–8. PMID 14644808. doi:10.1196/annals.1290.005.
Wada A, Waterman MR. . The Journal of Biological Chemistry. November 1992, 267 (32): 22877–82. PMID 1429635.
Hu MC, Guo IC, Lin JH, Chung BC. . The Biochemical Journal. March 1991, 274 (Pt 3): 813–7. PMC 1149983. PMID 1849407. doi:10.1042/bj2740813.
Sparkes RS, Klisak I, Miller WL. . DNA and Cell Biology. June 1991, 10 (5): 359–65. PMID 1863359. doi:10.1089/dna.1991.10.359.
Coghlan VM, Vickery LE. . The Journal of Biological Chemistry. October 1991, 266 (28): 18606–12. PMID 1917982.
Matteson KJ, Chung BC, Urdea MS, Miller WL. . Endocrinology. April 1986, 118 (4): 1296–305. PMID 2419119. doi:10.1210/endo-118-4-1296.
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. . Proceedings of the National Academy of Sciences of the United States of America. December 1986, 83 (23): 8962–6. PMC 387054. PMID 3024157. doi:10.1073/pnas.83.23.8962.
Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y. . Journal of Biochemistry. April 1987, 101 (4): 879–87. PMID 3038854.
Maruyama K, Sugano S. . Gene. January 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Gharani N, Waterworth DM, Batty S, White D, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R. . Human Molecular Genetics. March 1997, 6 (3): 397–402. PMID 9147642. doi:10.1093/hmg/6.3.397.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S. . Gene. October 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, Raunio H. . Pharmacology & Toxicology. February 1998, 82 (2): 93–7. PMID 9498238. doi:10.1111/j.1600-0773.1998.tb01404.x.
Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW. . Molecular and Cellular Endocrinology. March 1998, 138 (1–2): 61–9. PMID 9685215. doi:10.1016/S0303-7207(98)00052-5.

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[pmid22217824-1] Hanukoglu I. . The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.

[entrez-2] .