芳香烃受体

芳香烃受体
識別號
别名	AHR；, bHLHe76, aryl hydrocarbon receptor, Aryl hydrocarbon receptor, RP85
外部ID	OMIM：600253 MGI：105043 HomoloGene：1224 GeneCards：AHR
基因位置（人类）
染色体	染色体7（人类）[1]
终止	17,346,152 bp[1]
基因位置（小鼠）
染色体	染色体12（小鼠）[2]
终止	35,535,038 bp[2]
基因本體
分子功能	• DNA结合; • Hsp90 protein binding; • protein dimerization activity; • 转录因子结合; • nuclear receptor activity; • E-box binding; • 血浆蛋白结合; • protein heterodimerization activity; • DNA结合转录因子活性; • TFIID-class transcription factor binding; • transcription coactivator binding; • TBP-class protein binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein homodimerization activity; • sequence-specific double-stranded DNA binding;
細胞組分	• 細胞質; • 轉錄調節複合物; • cytosolic aryl hydrocarbon receptor complex; • nuclear aryl hydrocarbon receptor complex; • 细胞核; • aryl hydrocarbon receptor complex; • 细胞质基质; • 核质; • 大分子复合体;
生物學過程	• regulation of transcription, DNA-templated; • rhythmic process; • regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • circadian regulation of gene expression; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • regulation of B cell proliferation; • blood vessel development; • 基因調節; • xenobiotic metabolic process; • 細胞週期; • negative regulation of transcription, DNA-templated; • response to toxic substance; • positive regulation of transcription from RNA polymerase II promoter; • 细胞凋亡; • intracellular receptor signaling pathway; • response to xenobiotic stimulus; • cAMP-mediated signaling; • cellular response to cAMP; • cellular response to forskolin; • cellular response to 2,3,7,8-tetrachlorodibenzodioxine;
	Sources:Amigo / QuickGO
直系同源
	196
	11622
	ENSG00000106546
	ENSMUSG00000019256
	P35869
	P30561
	NM_001621
	NM_013464、NM_001314027
	NP_001612
	NP_001300956、NP_038492
	維基數據

芳香烃受体（英語：，或称为芳烃受体或芳基烃受体，简称为AhR或AHR）是碱性螺旋-环-螺旋转录因子家族中的一个成员。此受体的生理学配体未知，但他会结合一些例如天然植物黄酮类化合物、多酚类与吲哚类等外源配体，人造的多环芳烃以及二噁英样物质同样也是。AhR是一种通常情况下无活性而与一些共分子伴侣胞质溶胶结合的转录因子。一旦配体结合到例如2,3,7,8-四氯二苯二氧芑（TCDD）等化学物质上时，分子伴侣离解并导致AhR转移到细胞核中并与ARNT（芳香烃受体核转运体）二聚化，致使基因转录产生改变。

参考文献

GRCh38: Ensembl release 89: ENSG00000106546 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019256 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

MeSH（醫學主題詞）上面的Aryl+hydrocarbon+receptor（美式英语）

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106546 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019256 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.