骨涎蛋白

骨涎蛋白 Bone sialoprotein(BSP)是矿化组织如牙本质牙骨质和钙化软骨的组分。 BSP是骨细胞外基质的重要组分,并且已被认为构成牙骨质中发现的所有非胶原蛋白的约8%。[1]是一种唾液酸含量较高的最初分离自牛骨皮质的分子量为23-kDa的糖蛋白[2][3]SIBLING蛋白的一种。

BSP在人类中称为骨唾液蛋白2,也称为细胞结合唾液蛋白或整合素结合唾液蛋白,由IBSP基因编码。[4]

参考文献

  1. Fisher LW, McBride OW, Termine JD, Young MF (February 1990). "Human bone sialoprotein. Deduced protein sequence and chromosomal localization". J. Biol. Chem. 265 (4): 2347–51. PMID 2404984.
  2. Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone sialoprotein)". Biochim. Biophys. Acta. 101 (3): 327–35. doi:10.1016/0926-6534(65)90011-4. PMID 5862222.
  3. Herring GM (February 1964). "Comparison of bovine bone sialoprotein and serum orosomucoid". Nature. 201 (4920): 709. doi:10.1038/201709a0. PMID 14139700.
  4. Kerr JM, Fisher LW, Termine JD, Wang MG, McBride OW, Young MF (August 1993). "The human bone sialoprotein gene (IBSP): genomic localization and characterization". Genomics. 17 (2): 408–15. doi:10.1006/geno.1993.1340. PMID 8406493.
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