CD18

CD18
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1L3Y、1YUK、2JF1、2P26、2P28、3K6S、3K71、3K72、2V7D、4NEH、4NEN、5E6X、5E6V、5E6S、5E6R、5E6W、5ES4、5E6U
識別號
别名	ITGB2；, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
外部ID	OMIM：600065 MGI：96611 HomoloGene：20092 GeneCards：ITGB2
基因位置（人类）
染色体	染色体21（人类）[1]
终止	44,931,989 bp[1]
基因位置（小鼠）
染色体	染色体10（小鼠）[2]
终止	77,565,708 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 大分子复合物结合; • 金屬離子結合; • 血浆蛋白结合; • protein heterodimerization activity; • ICAM-3 receptor activity; • protein kinase binding; • cell adhesion molecule binding; • heat shock protein binding; • amyloid-beta binding; • complement component C3b binding; • integrin binding; • signaling receptor activity; • cargo receptor activity;
細胞組分	• integral component of membrane; • extracellular vesicle; • integrin alphaL-beta2 complex; • 膜; • 细胞膜; • receptor complex; • cell surface; • integrin complex; • 外排體; • specific granule membrane; • tertiary granule membrane; • ficolin-1-rich granule membrane; • 粘着斑; • external side of plasma membrane; • integrin alphaM-beta2 complex; • plasma membrane raft; • 脂筏模型; • cytoplasmic region; • 大分子复合体;
生物學過程	• leukocyte cell-cell adhesion; • endodermal cell differentiation; • toll-like receptor 4 signaling pathway; • positive regulation of nitric oxide biosynthetic process; • heterotypic cell-cell adhesion; • cell-cell signaling; • 老化; • receptor internalization; • leukocyte migration involved in inflammatory response; • natural killer cell activation; • cellular response to low-density lipoprotein particle stimulus; • extracellular matrix organization; • receptor clustering; • positive regulation of angiogenesis; • neutrophil chemotaxis; • 細胞粘附; • positive regulation of NF-kappaB transcription factor activity; • regulation of cell shape; • regulation of immune response; • cellular extravasation; • integrin-mediated signaling pathway; • cell-matrix adhesion; • inflammatory response; • endothelial cell migration; • leukocyte migration; • regulation of peptidyl-tyrosine phosphorylation; • 细胞凋亡; • 吞噬作用; • neutrophil degranulation; • microglial cell activation; • receptor-mediated endocytosis; • phagocytosis, engulfment; • 细胞迁移; • cytokine-mediated signaling pathway; • positive regulation of superoxide anion generation; • cell adhesion mediated by integrin; • positive regulation of neutrophil degranulation; • negative regulation of dopamine metabolic process; • positive regulation of protein targeting to membrane; • amyloid-beta clearance; • cell-cell adhesion; • cell-cell adhesion via plasma-membrane adhesion molecules; • positive regulation of neuron death; • positive regulation of microglial cell activation; • neutrophil migration; • positive regulation of prostaglandin-E synthase activity; • positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
直系同源
	3689
	16414
	ENSG00000160255
	ENSMUSG00000000290
	P05107
	P11835
	XM_006724001、NM_000211、NM_001127491、NM_001303238
	NM_008404、XM_006513271、XM_006513272、XM_017313814、NR_157228、NR_157229
	NP_000202、NP_001120963、NP_001290167、XP_006724064
	NP_032430、XP_006513334、XP_006513335、XP_017169303
	維基數據

整联蛋白β-2（英語：，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。

能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

淋巴球功能性抗原1，LFA-1 (搭配 CD11a)
巨噬细胞抗原的1 (搭配 CD11b)
整联蛋白αXβ2 (搭配 CD11c)
整联蛋白αDβ2 (搭配 CD11d)

相互作用

CD18已经与下列蛋白质进行交互作用：

FHL2[5]
GNB2L1[6]
ICAM-1[7][8][9]
PSCD1[10][11]

参考文献

GRCh38: Ensembl release 89: ENSG00000160255 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000290 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. . The Journal of Biological Chemistry. October 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
Liliental J, Chang DD. . The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG. . Journal of Immunology. June 1999, 162 (11): 6613–20. PMID 10352278.
Lu C, Takagi J, Springer TA. . The Journal of Biological Chemistry. May 2001, 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200.
Huang C, Springer TA. . The Journal of Biological Chemistry. August 1995, 270 (32): 19008–16. PMID 7642561. doi:10.1074/jbc.270.32.19008.
Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B. . The Journal of Biological Chemistry. October 1998, 273 (42): 27459–66. PMID 9765275. doi:10.1074/jbc.273.42.27459.
Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W. . The EMBO Journal. June 2000, 19 (11): 2525–36. PMC 212768. PMID 10835351. doi:10.1093/emboj/19.11.2525.

外部链接

MeSH（醫學主題詞）
上面的CD18+antigen
ITGB2 信息的链接在单元的移徙网关
Human ITGB2 genome location and ITGB2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160255 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000290 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10906324-5] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. . The Journal of Biological Chemistry. October 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.

[pmid9442085-6] Liliental J, Chang DD. . The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.

[pmid10352278-7] Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG. . Journal of Immunology. June 1999, 162 (11): 6613–20. PMID 10352278.

[pmid11279101-8] Lu C, Takagi J, Springer TA. . The Journal of Biological Chemistry. May 2001, 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200.

[pmid7642561-9] Huang C, Springer TA. . The Journal of Biological Chemistry. August 1995, 270 (32): 19008–16. PMID 7642561. doi:10.1074/jbc.270.32.19008.

[pmid9765275-10] Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B. . The Journal of Biological Chemistry. October 1998, 273 (42): 27459–66. PMID 9765275. doi:10.1074/jbc.273.42.27459.

[pmid10835351-11] Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W. . The EMBO Journal. June 2000, 19 (11): 2525–36. PMC 212768. PMID 10835351. doi:10.1093/emboj/19.11.2525.