CD90

CD90
識別號
别名	THY1；, CD90, CDw90, Thy-1 cell surface antigen
外部ID	OMIM：188230 MGI：98747 HomoloGene：4580 GeneCards：THY1
基因位置（人类）
染色体	染色体11（人类）[1]
终止	119,424,985 bp[1]
基因位置（小鼠）
染色体	染色体9（小鼠）[2]
终止	44,048,579 bp[2]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • 酶结合; • GPI anchor binding; • GTPase activator activity; • protein kinase binding; • integrin binding;
細胞組分	• 细胞质基质; • 膜; • 粘着斑; • 生长锥; • anchored component of plasma membrane; • integral component of plasma membrane; • apical plasma membrane; • 内质网; • anchored component of membrane; • 外排體; • external side of plasma membrane; • 脂筏模型; • anchored component of external side of plasma membrane; • 树突; • 髓磷脂; • 細胞外區域; • 细胞膜; • cell surface; • axolemma; • dendrite membrane; • neuronal cell body membrane;
生物學過程	• negative regulation of T cell receptor signaling pathway; • positive regulation of GTPase activity; • 自體磷酸化; • negative regulation of protein kinase activity; • 細胞粘附; • negative regulation of cell migration; • 血管新生; • negative regulation of axonogenesis; • 细胞骨架组织; • regulation of cell migration; • positive regulation of T cell activation; • T cell receptor signaling pathway; • retinal cone cell development; • positive regulation of release of sequestered calcium ion into cytosol; • C-terminal protein lipidation; • regulation of cell-matrix adhesion; • positive regulation of cellular extravasation; • integrin-mediated signaling pathway; • cell-cell signaling; • positive regulation of heterotypic cell-cell adhesion; • receptor clustering; • positive regulation of focal adhesion assembly; • negative regulation of protein tyrosine kinase activity; • negative regulation of neuron projection regeneration; • regulation of Rho-dependent protein serine/threonine kinase activity; • focal adhesion assembly; • cell-cell adhesion;
	Sources:Amigo / QuickGO
直系同源
	7070
	21838
	ENSG00000154096
	ENSMUSG00000032011
	P04216
	P01831
	NM_006288、NM_001311160、NM_001311162、NM_001372050、NR_164077
	NM_009382
	NP_001298089、NP_001298091、NP_006279、NP_001358979
	NP_033408
	維基數據

Thy-1 或 CD90（Cluster of Differentiation 90，分化簇90）是一个25-37kDa重度N-糖基化的细胞表面蛋白质，通过C-末端的糖磷脂酰肌醇（glycophosphatidylinositol，GPI）锚定到细胞膜外侧。CD90最初作为一个胸腺細胞的表面抗原发现，故最早称为Thy-1。此后，Thy-1不断在各种幹細胞和轴突分化成熟的的神經元上发现，现在更倾向于称作CD90。CD90带有一个V型的免疫球蛋白结构域，是免疫球蛋白超家族的一员，几乎是其中分子量最小的成员。

参考文献

GRCh38: Ensembl release 89: ENSG00000154096 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032011 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

Human THY1 genome location and THY1 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154096 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032011 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.