CXCL10

CXCL10（英語：）是一小分子的细胞因子属于CXC趋化因子家族[1]，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）[2] 。干扰素伽玛可以在多种细胞（如巨噬细胞[3] ，单核细胞[3] ，内皮细胞[4]和成纤维细胞）中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用[5][6]，促进T细胞黏附于内皮细胞[4]，抗肿瘤[7]，及新血管形成[4]。人类的CXCL10基因与CXCL9，CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[5][6] 。

Chemokine (C-X-C motif) ligand 10
PDB rendering based on 1o7z.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 CXCL10; C7; IFI10; INP10; IP-10; SCYB10; crg-2; gIP-10; mob-1
扩展标识 遗传学：147310 鼠基因：1352450 同源基因：1203 GeneCards: CXCL10 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 3627 15945
Ensembl ENSG00000169245 ENSMUSG00000034855
UniProt P02778 P17515
mRNA序列 NM_001565 NM_021274
蛋白序列 NP_001556 NP_067249
基因位置 Chr 4:
76.94 – 76.94 Mb		 Chr 5:
92.35 – 92.35 Mb
PubMed查询

参见

参考文献
  1. Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
  2. Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
  3. Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
  4. Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
  5. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  6. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  7. Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接
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