CYP2D6
细胞色素 P450 2D6(英語:)是一种由人类CYP2D6基因编码的酶。CYP2D6主要在肝脏,并且也在中枢神经系统中,包括黑质。
CYP2D6是细胞色素P450混合功能氧化酶系统的成员之一,是人体中最重要的代谢酶之一。CYP2D6参与25%的临床药物的代谢和清除,过程主要是O-去甲基化。[1]CYP2D6也参与多种内源性物质的代谢,如5-羟色胺和神经类固醇。[1]
引用
- Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF. . Drug Metab. Rev. 2009, 41 (4): 573–643. PMID 19645588. doi:10.1080/03602530903118729.
延伸閱讀
- Smith G, Stubbins MJ, Harries LW, Wolf CR. . Xenobiotica. 1998, 28 (12): 1129–65. PMID 9890157. doi:10.1080/004982598238868.
- Wolf CR, Smith G. . IARC Sci. Publ. 1999, (148): 209–29. PMID 10493260.
- Ding X, Kaminsky LS. . Annu. Rev. Pharmacol. Toxicol. 2003, 43 (1): 149–73. PMID 12171978. doi:10.1146/annurev.pharmtox.43.100901.140251.
- Lilienfeld S. . CNS Drug Rev. 2002, 8 (2): 159–76. PMID 12177686. doi:10.1111/j.1527-3458.2002.tb00221.x.
- Yu AM, Idle JR, Gonzalez FJ. . Drug Metab. Rev. 2004, 36 (2): 243–77. PMID 15237854. doi:10.1081/DMR-120034000.
- Abraham JE, Maranian MJ, Driver KE, Platte R, Kalmyrzaev B, Baynes C, Luccarini C, Shah M, Ingle S, Greenberg D, Earl HM, Dunning AM, Pharoah PD, Caldas C. . Breast Cancer Res. 2010, 12 (4): R64. PMC 2949659. PMID 20731819. doi:10.1186/bcr2629.
- Abraham JE, Maranian MJ, Driver KE, Platte R, Kalmyrzaev B, Baynes C, Luccarini C, Earl HM, Dunning AM, Pharoah PD, Caldas C. . Cancer Epidemiol. Biomarkers Prev. 2011, 20 (6): 1255–8. PMID 21527579. doi:10.1158/1055-9965.EPI-11-0321.
外部連結
- Flockhart Lab Cyp2D6 Substrates Page页面存档备份,存于 at IUPUI
- PharmGKB: Annotated PGx Gene Information for CYP2D6
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.