IgM
描述
与B细胞表面结合的是单体形式,在分泌形态中则是由五個Y型單體排列而成的五聚体形式,具有极高的亲和力。又因其分子量極大,因此在抗原凝集反應中非常有效。在B细胞介导(体液)免疫的早期阶段IgG尚不充足,此时则主要由IgM来发挥清除病原的作用。同時為初次遭遇外來抗原後,最早回應出現的循環性抗體,但IgM在血液中的濃度会因清除作用迅速下降。因此,IgM通常可當做感染的指標。[3][4]
参见
参考文献
- Houghton Mifflin Company, 2004. "Immunoglobulin M." The American Heritage Dictionary of the English Language, Fourth Edition. Accessed on 12 Oct. 2007
- http://www.jimmunol.org/content/186/2/1011.full 页面存档备份,存于 ; Bailey & Love's Short Practice of Surgery, 25ed (Ch-62, pg-1102)
- Pier GB, Lyczak JB, Wetzler LM. . ASM Press. 2004. ISBN 1-55581-246-5.
- Geisberger R, Lamers M, Achatz G. . Immunology. 2006, 118 (4): 429–437. PMC 1782314. PMID 16895553. doi:10.1111/j.1365-2567.2006.02386.x.
外部链接
- MeSH(醫學主題詞)上面的Immunoglobulin+M(美式英语)
- Immunoglobulin M Deficiency Reference页面存档备份,存于 from Medscape.com
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