Nierenstein反应
反应机理
反应机理与Arndt-Eistert反应类似,即酰氯与重氮甲烷缩合为重氮酮中间体,然后重氮酮发生质子化、放出氮气得到产物。
以苯乙酰氯合成苄基氯甲基酮时,需要通入氯化氢气体才能使重氮酮转化为卤代酮产物。[3]
参考资料
- Clibbens, D.; Nierenstein, M. . J. Chem. Soc. 1915, 107: 1491. doi:10.1039/CT9150701491.
- Bachman, W. E.; Struve, W. S. Org. React. 1942, 1: 38. 缺少或
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为空 (帮助)(综述) - McPhee, W. D; Klingsberg, E. Organic Syntheses, Coll. Vol. 3, p.119 (1955); Vol. 26, p.13 (1946). (Article 页面存档备份,存于)
- M. Nierenstein, D. G. Wang, and J. C. Warr. . J. Am. Chem. Soc. 1924, 46 (11): 2551–2555. doi:10.1021/ja01676a028.
- H. H. Lewis, M. Nierenstein, and Enid M. Rich. . J. Am. Chem. Soc. 1925, 47 (6): 1728–1732. doi:10.1021/ja01683a036.
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