P73

P73
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4GUQ、1COK、1DXS、2KBY、2MPS、2WQI、2WQJ、2WTT、2XWC、3VD0、3VD1、3VD2、4A63、4G82、4G83、4GUO
識別號
别名	TP73；, P73, tumor protein p73
外部ID	OMIM：601990 MGI：1336991 HomoloGene：3960 GeneCards：TP73
基因位置（人类）
染色体	1號染色體[1]
终止	3,736,201 bp[1]
基因位置（小鼠）
染色体	小鼠4号染色体[2]
终止	154,140,208 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • chromatin binding; • 金屬離子結合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • damaged DNA binding; • 血浆蛋白结合; • 相同蛋白质结合; • protein kinase binding; • p53 binding; • DNA结合转录因子活性; • MDM2/MDM4 family protein binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞組分	• 細胞質; • 高尔基体; • 細胞內膜結合細胞器; • 轉錄調節複合物; • 细胞连接; • 染色质; • 细胞核; • 線粒體; • 核质; • 细胞质基质;
生物學過程	• negative regulation of neuron apoptotic process; • positive regulation of oligodendrocyte differentiation; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of transcription, DNA-templated; • negative regulation of neuron differentiation; • 后肾; • cellular response to UV; • negative regulation of transcription from RNA polymerase II promoter; • protein tetramerization; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • activation of MAPK activity; • mitotic G1 DNA damage checkpoint; • cell cycle arrest; • response to organonitrogen compound; • intrinsic apoptotic signaling pathway in response to DNA damage; • regulation of mitotic cell cycle; • positive regulation of apoptotic process; • 基因調節; • mismatch repair; • 細胞週期; • negative regulation of cardiac muscle cell proliferation; • viral process; • negative regulation of JUN kinase activity; • response to gamma radiation; • response to X-ray; • response to drug; • positive regulation of transcription from RNA polymerase II promoter; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • negative regulation of cell proliferation; • positive regulation of cell cycle arrest; • 细胞凋亡; • regulation of signal transduction by p53 class mediator; • transcription from RNA polymerase II promoter; • regulation of apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • positive regulation of transcription, DNA-templated; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	7161
	22062
	ENSG00000078900
	ENSMUSG00000029026
	O15350
	Q9JJP2
NM_001126240; NM_001126241; NM_001126242; NM_001204184; NM_001204185;
	NM_001204186; NM_001204187; NM_001204188; NM_001204189; NM_001204190; NM_001204191; NM_001204192; NM_005427
	NM_001126330; NM_001126331; NM_011642
NP_001119712; NP_001119713; NP_001119714; NP_001191113; NP_001191114;
	NP_001191115; NP_001191116; NP_001191117; NP_001191118; NP_001191119; NP_001191120; NP_001191121; NP_005418
	NP_001119802; NP_001119803; NP_035772
	維基數據

p73，又稱爲TP73，是p53蛋白家族的成員之一，以其分子量爲73kD而得名，存在多種轉錄變體。p73的結構和功能均與p53類似，爲腫瘤抑制蛋白，能調控細胞增殖並促進細胞凋亡。過表達p73的細胞增殖會停止。

參見

p53
p63

參考文獻

GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.