TAS2R38
TAS2R38是一种苦味味觉感受器[1][2],该感受器可以尝出苯硫脲[3]和丙硫氧嘧啶[4]或者相关物质的苦味。这一点和大多数苦味感受器有所不同,即该感受器是对某类物质敏感,而大多数感受器则不会表现出强烈的选择性,能对多种物质做出响应[5]。该感受器所能尝出的相应物质大量存在于西兰花、卷心菜以及其它十字花科植物中[5],例如:葡萄糖异硫氰酸盐及其相关产物异硫氰酸酯。目前全球人类中,约有75%该感受器相关基因正常,即,可以尝出苦味。而剩下的25%则无法尝出这类的苦味,或者敏感度较低[6]。 不过目前的研究表明该感受器相关基因的变异与否,并不是决定某个人是否此类苦味物质的超级品尝家的唯一因素。[7]
味觉感受器,类型2,成员38 | |||||||||||||
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标识 | |||||||||||||
代号 | TAS2R38; PTC; T2R61 | ||||||||||||
扩展标识 | 遗传学:607751 鼠基因:2681306 同源基因:47976 GeneCards: TAS2R38 Gene | ||||||||||||
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直系同源体 | |||||||||||||
物种 | 人类 | 小鼠 | |||||||||||
Entrez | 5726 | 387513 | |||||||||||
Ensembl | ENSG00000183609 | ENSMUSG00000058250 | |||||||||||
UniProt | P59533 | A0PK79 | |||||||||||
mRNA序列 | NM_176817 | NM_001001451 | |||||||||||
蛋白序列 | NP_789787 | NP_001001451 | |||||||||||
基因位置 |
Chr 7: 141.32 – 141.32 Mb |
Chr 6: 40.54 – 40.54 Mb | |||||||||||
PubMed查询 |
引用
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