周期蛋白A1
该基因编码的蛋白质属于高度保守的周期蛋白家族,该家族成员的显著特征是贯穿细胞周期,其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK(周期蛋白依赖性激酶)的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性,这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中,现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1和Cdk2两种激酶相结合,但这两种激酶活性完全不相同,前者激酶活性表现于G2期,而后者激酶活性表现于S期,因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上,后者如:Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族[2]。
Cyclin A1 周期素A1 | |||
---|---|---|---|
标识 | |||
代号 | CCNA1 | ||
扩展标识 | 遗传学:604036 鼠基因:108042 同源基因:31203 ChEMBL: 3609 GeneCards: CCNA1 Gene | ||
RNA表达模式 | |||
更多表达数据 | |||
直系同源体 | |||
物种 | 人类 | 小鼠 | |
Entrez | 8900 | 12427 | |
Ensembl | ENSG00000133101 | ENSMUSG00000027793 | |
UniProt | P78396 | Q61456 | |
mRNA序列 | NM_001111045 | NM_007628 | |
蛋白序列 | NP_001104515 | NP_031654 | |
基因位置 |
Chr 13: 37.01 – 37.02 Mb |
Chr 3: 55.05 – 55.06 Mb | |
PubMed查询 | |||
参考文献
- Yang R, Morosetti R, Koeffler HP. . Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.
- .
- Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. . Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032. PMID 10022926.
- Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. . Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.
- Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. . Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.
- Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. . Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.
- Brown, N R; Noble M E, Endicott J A, Johnson L N. . Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.
- Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. . J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.
延伸阅读
- Hall M, Bates S, Peters G. . Oncogene. 1995, 11 (8): 1581–8. PMID 7478582.
- Xu M, Sheppard KA, Peng CY; 等. . Mol. Cell. Biol. 1994, 14 (12): 8420–31. PMC 359381. PMID 7969176.
- Maruyama K, Sugano S. . Gene. 1994, 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- O'Connor PM, Ferris DK, Pagano M; 等. . J. Biol. Chem. 1993, 268 (11): 8298–308. PMID 8463339.
- Sweeney C, Murphy M, Kubelka M; 等. . Development. 1996, 122 (1): 53–64. PMID 8565853.
- Wang H, Shao N, Ding QM; 等. . Oncogene. 1997, 15 (2): 143–57. PMID 9244350. doi:10.1038/sj.onc.1201252.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; 等. . Gene. 1997, 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Liu D, Matzuk MM, Sung WK; 等. . Nat. Genet. 1998, 20 (4): 377–80. PMID 9843212. doi:10.1038/3855.
- Yang R, Müller C, Huynh V; 等. . Mol. Cell. Biol. 1999, 19 (3): 2400–7. PMC 84032. PMID 10022926.
- Ravnik SE, Wolgemuth DJ. . Dev. Biol. 1999, 207 (2): 408–18. PMID 10068472. doi:10.1006/dbio.1998.9156.
- Yang R, Nakamaki T, Lübbert M; 等. . Blood. 1999, 93 (6): 2067–74. PMID 10068680.
- Müller C, Yang R, Beck-von-Peccoz L; 等. . J. Biol. Chem. 1999, 274 (16): 11220–8. PMID 10196209. doi:10.1074/jbc.274.16.11220.
- Ruffner H, Jiang W, Craig AG; 等. . Mol. Cell. Biol. 1999, 19 (7): 4843–54. PMC 84283. PMID 10373534.
- Brown NR, Noble ME, Endicott JA, Johnson LN. . Nat. Cell Biol. 2001, 1 (7): 438–43. PMID 10559988. doi:10.1038/15674.
- Liu D, Liao C, Wolgemuth DJ. . Dev. Biol. 2000, 224 (2): 388–400. PMID 10926775. doi:10.1006/dbio.2000.9776.
- Hartley JL, Temple GF, Brasch MA. . Genome Res. 2001, 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000.
- Müller-Tidow C, Bornemann C, Diederichs S; 等. . FEBS Lett. 2001, 490 (1-2): 75–8. PMID 11172814. doi:10.1016/S0014-5793(01)02128-7.
- Simpson JC, Wellenreuther R, Poustka A; 等. . EMBO Rep. 2001, 1 (3): 287–92. PMC 1083732. PMID 11256614. doi:10.1093/embo-reports/kvd058.
- Müller-Tidow C, Wang W, Idos GE; 等. . Blood. 2001, 97 (7): 2091–7. PMID 11264176. doi:10.1182/blood.V97.7.2091.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.