孕酮受体

現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

Progesterone receptor, N-terminal
鑑定
標誌	Progest_rcpt_N
Pfam	PF02161
InterPro	IPR000128
現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要

Progesterone receptor; 孕酮受体
	PDB rendering based on 1a28.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU
标识
代号	PGR; NR3C3; PR
扩展标识	遗传学：607311 鼠基因：97567 同源基因：713 IUPHAR: ChEMBL: 208 GeneCards: PGR Gene
基因本体论描述
分子功能	· DNA binding; · steroid hormone receptor activity; · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; · receptor binding; · steroid binding; · protein binding; · zinc ion binding; · enzyme binding; · sequence-specific DNA binding;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · intracellular membrane-bounded organelle;
生物过程	· ovulation from ovarian follicle; · epithelial cell maturation; · transcription initiation from RNA polymerase II promoter; · signal transduction; · cell-cell signaling; · gene expression; · negative regulation of gene expression; · regulation of epithelial cell proliferation; · progesterone receptor signaling pathway; · tertiary branching involved in mammary gland duct morphogenesis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

孕酮受体（英語：，缩写PR，也被称为NR3C3 ，nuclear receptor subfamily 3, group C, member 3，即核受体第三亚族C组成员3）是一种细胞内蛋白质，由甾体激素孕酮激活。

在人体中，孕酮受体由基因PGR 编码，位于11号染色体长臂22区[1][2][3]，能通过选择性剪接形成两种蛋白异形体A和B，有着各自不同的分子量[4][5][6]。

功能

孕酮是引起孕酮受体反应的配体，在孕酮受体的C端未结合该激素时，与其相关的DNA片段的转录处于抑制状态。在与激素结合后，孕酮受体会变构并开始起作用。而孕酮受体的受体拮抗剂会阻止这种结构改变。

在孕酮与其受体结合后，孕酮受体变构并发生二聚化，紧接着以复合体形式进入细胞核与相关的DNA结合，从而使其开始转录，合成mRNA，并表达为相关蛋白质。

结构

和其它甾体激素受体类似，孕酮受体的N端有一个调控结构域，一个DNA结合结构域，以及一个铰链区，在C端有一个配体结合结构域。异形体B比异形体A多一个TAF-3区域。

交互作用

孕酮受体能与下列蛋白質发生交互作用：

KLF9[7]
Nuclear receptor co-repressor 2[8]
UBE3A[9]

另见

Selective progesterone receptor modulator

参考文献

Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E. . Biochem. Biophys. Res. Commun. March 1987, 143 (2): 740–8. PMID 3551956. doi:10.1016/0006-291X(87)91416-1.
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ensembl.org, Gene: ESR1 (ENSG00000091831)
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Kase, Nathan G.; Speroff, Leon; Glass, Robert L. . Hagerstown, MD: Lippincott Williams & Wilkins. 1999. ISBN 0-683-30379-1.
Fritz, Marc A.; Speroff, Leon. . Hagerstown, MD: Lippincott Williams & Wilkins. 2005. ISBN 0-7817-4795-3.
Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. . J. Biol. Chem. June 2003, 278 (24): 21474–82. PMID 12672823. doi:10.1074/jbc.M212098200.
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外部链接

MeSH（醫學主題詞）上面的Progesterone+Receptors（美式英语）

此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR000342

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid3551956-1] Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E. . Biochem. Biophys. Res. Commun. March 1987, 143 (2): 740–8. PMID 3551956. doi:10.1016/0006-291X(87)91416-1.

[pmid3472240-2] Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW. . Proc. Natl. Acad. Sci. U.S.A. May 1987, 84 (9): 2877–81. PMC 304763. PMID 3472240. doi:10.1073/pnas.84.9.2877.

[3] sembl.org, Gene: ESR1 (ENSG00000091831)

[pmid15970482-4] Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C. . Front. Biosci. 2005, 10: 2118–30. PMID 15970482. doi:10.2741/1685.

[isbn0-683-30379-1-5] Kase, Nathan G.; Speroff, Leon; Glass, Robert L. . Hagerstown, MD: Lippincott Williams & Wilkins. 1999. ISBN 0-683-30379-1.

[isbn0-7817-4795-3-6] Fritz, Marc A.; Speroff, Leon. . Hagerstown, MD: Lippincott Williams & Wilkins. 2005. ISBN 0-7817-4795-3.

[pmid12672823-7] Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. . J. Biol. Chem. June 2003, 278 (24): 21474–82. PMID 12672823. doi:10.1074/jbc.M212098200.

[pmid10757795-8] Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. . Mol. Cell. Biol. May 2000, 20 (9): 3102–15. PMC 85605. PMID 10757795. doi:10.1128/MCB.20.9.3102-3115.2000.

[pmid9891052-9] Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW. . Mol. Cell. Biol. February 1999, 19 (2): 1182–9. PMC 116047. PMID 9891052.