富亮氨酸重复

現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要
PDB	1ogqA:155–177 1jl5A:358–382 1g9uA:358–382 1k5dF:123–149 2ca6A:123–149 1yrgA:123–149 1k5gF:123–149 1k15A:165–187 1m0zA:165–187 1u0nD:165–187 1qyyG:165–187 1sq0B:165–187 1m10B:165–187 1ookG:165–187 1k13A:165–187 1p9aG:165–187 1p8vA:165–187 1k14A:165–187 1ziwA:563–585 2a0zA:563–585 1wwlA:292–318 1p8tA:131–153 1oznA:131–153 1xum :54–75 1xcdA:131–149 1xecB:131–149 1xkuA:131–149 1xwdC:194–217 1xun :194–217 1o6sA:274–294 1kohB:292–315 1fo1B:292–315 1ft8D:292–315 1kooC:292–315 2bnh :337–360 1dfjI:337–360 1a4yD:114–137 2bexA:114–137 1z7xW:114–137 1dceA:509–532 1ltxA:509–532 1p95B:551–560 1xeuA:162–182 1m9lA:116–139 1ds9A:116–139 1m9sA:165–185 1h6tA:165–185 1otmA:165–185 1otoA:165–185 1d0bA:165–185 1otnA:165–185 1h6uA:209–229 1w8aA:596–618 1a9nA:89–109

	富亮氨酸重复蛋白一例：猪核糖核酸酶抑制因子
鑑定
標誌	LRR_1
Pfam	PF00560
Pfam宗系	CL0022
InterPro	IPR001611
SCOP	2bnh / SUPFAM
OPM蛋白	1xwd
現有可用的蛋白結構：
Pfam	結構 / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要
PDB	1ogqA:155–177 1jl5A:358–382 1g9uA:358–382 1k5dF:123–149 2ca6A:123–149 1yrgA:123–149 1k5gF:123–149 1k15A:165–187 1m0zA:165–187 1u0nD:165–187 1qyyG:165–187 1sq0B:165–187 1m10B:165–187 1ookG:165–187 1k13A:165–187 1p9aG:165–187 1p8vA:165–187 1k14A:165–187 1ziwA:563–585 2a0zA:563–585 1wwlA:292–318 1p8tA:131–153 1oznA:131–153 1xum :54–75 1xcdA:131–149 1xecB:131–149 1xkuA:131–149 1xwdC:194–217 1xun :194–217 1o6sA:274–294 1kohB:292–315 1fo1B:292–315 1ft8D:292–315 1kooC:292–315 2bnh :337–360 1dfjI:337–360 1a4yD:114–137 2bexA:114–137 1z7xW:114–137 1dceA:509–532 1ltxA:509–532 1p95B:551–560 1xeuA:162–182 1m9lA:116–139 1ds9A:116–139 1m9sA:165–185 1h6tA:165–185 1otmA:165–185 1otoA:165–185 1d0bA:165–185 1otnA:165–185 1h6uA:209–229 1w8aA:596–618 1a9nA:89–109

富亮氨酸重复（leucine-rich repeat，LRR）是一种α/β 马蹄形折叠形式的蛋白质结构模体[1][2]，由20–30个疏水氨基酸残基组成（通常大部分是亮氨酸，因而得名）。这些重复通常会折叠到一起，形成一种螺线管状的蛋白质结构域，称为富亮氨酸重复结构域。典型的富亮氨酸重复中，每一个重复单元都有一个β折叠-转角-α螺旋结构，其形成的结构域包含许多这样的重复，并组成一个马蹄状结构（如右图，猪核糖核酸酶抑制因子），α螺旋在其外侧，β折叠在其内侧平行分布。β折叠的一面与α螺旋的一侧与外界的溶剂相接触，因此主要为親水性氨基酸残基。α螺旋与β折叠之间的区域为蛋白的疏水核，分子结构紧密且富含亮氨酸残基。

富亮氨酸重复常涉及蛋白-蛋白相互作用的形成。[3][4]

另见

亮氨酸拉链

参考文献

Kobe B, Deisenhofer J. . Trends Biochem. Sci. October 1994, 19 (10): 415–21. PMID 7817399. doi:10.1016/0968-0004(94)90090-6.
Enkhbayar P, Kamiya M, Osaki M, Matsumoto T, Matsushima N. . Proteins. February 2004, 54 (3): 394–403. PMID 14747988. doi:10.1002/prot.10605.
Kobe B, Kajava AV. . Curr. Opin. Struct. Biol. December 2001, 11 (6): 725–32 [2017-04-07]. PMID 11751054. doi:10.1016/S0959-440X(01)00266-4. （原始内容存档于2018-01-27）.
Gay NJ, Packman LC, Weldon MA, Barna JC. . FEBS Lett. October 1991, 291 (1): 87–91 [2017-04-07]. PMID 1657640. doi:10.1016/0014-5793(91)81110-T. （原始内容存档于2018-01-27）.

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[pmid7817399-1] Kobe B, Deisenhofer J. . Trends Biochem. Sci. October 1994, 19 (10): 415–21. PMID 7817399. doi:10.1016/0968-0004(94)90090-6.

[pmid14747988-2] Enkhbayar P, Kamiya M, Osaki M, Matsumoto T, Matsushima N. . Proteins. February 2004, 54 (3): 394–403. PMID 14747988. doi:10.1002/prot.10605.

[pmid11751054-3] Kobe B, Kajava AV. . Curr. Opin. Struct. Biol. December 2001, 11 (6): 725–32 [2017-04-07]. PMID 11751054. doi:10.1016/S0959-440X(01)00266-4. （原始内容存档于2018-01-27）.

[pmid1657640-4] Gay NJ, Packman LC, Weldon MA, Barna JC. . FEBS Lett. October 1991, 291 (1): 87–91 [2017-04-07]. PMID 1657640. doi:10.1016/0014-5793(91)81110-T. （原始内容存档于2018-01-27）.