早幼粒细胞白血病蛋白

Promyelocytic leukemia; 早幼粒细胞白血病蛋白
	PDB rendering based on 1bor.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1BOR
标识
代号	PML; MYL; PP8675; RNF71; TRIM19
扩展标识	遗传学：102578 鼠基因：104662 同源基因：13245 GeneCards: PML Gene
基因本体论描述
分子功能	· DNA binding; · transcription coactivator activity; · protein binding; · zinc ion binding; · ubiquitin protein ligase binding; · SUMO binding; · protein homodimerization activity; · SMAD binding; · protein heterodimerization activity; · cobalt ion binding;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · cytosol; · nuclear matrix; · PML body; · early endosome membrane; · nuclear membrane; · extrinsic component of endoplasmic reticulum membrane;
生物过程	· response to hypoxia; · regulation of protein phosphorylation; · positive regulation of defense response to virus by host; · transcription, DNA-templated; · regulation of transcription, DNA-templated; · protein complex assembly; · protein targeting; · apoptotic process; · activation of cysteine-type endopeptidase activity involved in apoptotic process; · DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; · cell cycle arrest; · transforming growth factor beta receptor signaling pathway; · common-partner SMAD protein phosphorylation; · SMAD protein import into nucleus; · negative regulation of cell proliferation; · intrinsic apoptotic signaling pathway in response to DNA damage; · intrinsic apoptotic signaling pathway in response to oxidative stress; · response to UV; · response to gamma radiation; · regulation of calcium ion transport into cytosol; · viral process; · negative regulation of angiogenesis; · cytokine-mediated signaling pathway; · myeloid cell differentiation; · negative regulation of cell growth; · PML body organization; · positive regulation of histone deacetylation; · negative regulation of telomere maintenance via telomerase; · endoplasmic reticulum calcium ion homeostasis; · circadian regulation of gene expression; · negative regulation of translation in response to oxidative stress; · response to cytokine; · regulation of circadian rhythm; · intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; · entrainment of circadian clock by photoperiod; · proteasome-mediated ubiquitin-dependent protein catabolic process; · innate immune response; · cell fate commitment; · regulation of MHC class I biosynthetic process; · negative regulation of transcription, DNA-templated; · negative regulation of mitotic cell cycle; · retinoic acid receptor signaling pathway; · protein stabilization; · maintenance of protein location in nucleus; · defense response to virus; · negative regulation of telomerase activity; · positive regulation of apoptotic process involved in mammary gland involution; · interferon-gamma-mediated signaling pathway; · branching involved in mammary gland duct morphogenesis; · intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; · cellular response to interleukin-4; · cellular senescence; · extrinsic apoptotic signaling pathway; · negative regulation of viral release from host cell; · negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; · regulation of double-strand break repair; · positive regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
直系同源体

早幼粒细胞白血病蛋白是指可能的转录因子可能的转录因子（英語：），是一个由人类基因 PML 编码的抑癌蛋白。

互作

早幼粒细胞白血病蛋白可与下列蛋白質发生交互作用：

ANKRD2,[1]
CREB-binding protein,[2][3][4]
Cyclin T1,[5]
Death associated protein 6,[6][7][8][9]
GATA2,[10]
HDAC1,[11][12]
HDAC3,[12]
HHEX,[13]
MAPK11,[14]
MYB,[15]
Mdm2,[16][17][18][19]
Nerve Growth factor IB,[20]
Nuclear receptor co-repressor 1,[11]
Nuclear receptor co-repressor 2,[11][21]
P53,[16][22][23]
RPL11,[17]
视网膜母细胞瘤蛋白[24]
视黄酸受体α,[2]
SIN3A,[11]
SKI protein,[11]
STAT3,[25]
Serum response factor[3] and
Small ubiquitin-related modifier 1,[26][27]
Sp1 transcription factor,[28]
TOPBP1,[29]
Thymine-DNA glycosylase,[30] and
Zinc finger and BTB domain-containing protein 16.[31]

参见

RING finger domain

参考文献

Kojic, S; Medeot, E; Guccione, E; Krmac, H; Zara, I; Martinelli, V; 等. . J. Mol. Biol. May 2004, 339 (2): 313–25. PMID 15136035. doi:10.1016/j.jmb.2004.03.071. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Zhong, S; Delva, L; Rachez, C; Cenciarelli, C; Gandini, D; Zhang, H; 等. . Nat. Genet. Nov 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Matsuzaki, K; Minami, T; Tojo, M; Honda, Y; Saitoh, N; Nagahiro, S; 等. . Genes Cells. Mar 2003, 8 (3): 275–86. PMID 12622724. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Doucas, V; Tini, M; Egan, DA; Evans, RM. . Proc. Natl. Acad. Sci. U.S.A. Mar 1999, 96 (6): 2627–32. PMC 15819. PMID 10077561. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Marcello, A; Ferrari, A; Pellegrini, V; Pegoraro, G; Lusic, M; Beltram, F; 等. . EMBO J. May 2003, 22 (9): 2156–66. PMC 156077. PMID 12727882. doi:10.1093/emboj/cdg205. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Ishov, AM; Sotnikov, AG; Negorev, D; Vladimirova, OV; Neff, N; Kamitani, T; 等. . J. Cell Biol. Oct 1999, 147 (2): 221–34. PMC 2174231. PMID 10525530. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Li, H; Leo, C; Zhu, J; Wu, X; O'Neil, J; Park, EJ; 等. . Mol. Cell. Biol. Mar 2000, 20 (5): 1784–96. PMC 85360. PMID 10669754. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Lehembre, F; Müller, S; Pandolfi, PP; Dejean, A. . Oncogene. Jan 2001, 20 (1): 1–9. PMID 11244500. doi:10.1038/sj.onc.1204063. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Zhong, S; Salomoni, P; Ronchetti, S; Guo, A; Ruggero, D; Pandolfi, PP. . J. Exp. Med. Feb 2000, 191 (4): 631–40. PMC 2195846. PMID 10684855. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Tsuzuki, S; Towatari, M; Saito, H; Enver, T. . Mol. Cell. Biol. Sep 2000, 20 (17): 6276–86. PMC 86102. PMID 10938104. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Khan, MM; Nomura, T; Kim, H; Kaul, SC; Wadhwa, R; Shinagawa, T; 等. . Mol. Cell. Jun 2001, 7 (6): 1233–43. PMID 11430826. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Wu, WS; Vallian, S; Seto, E; Yang, WM; Edmondson, D; Roth, S; 等. . Mol. Cell. Biol. Apr 2001, 21 (7): 2259–68. PMC 86860. PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Topcu, Z; Mack, DL; Hromas, RA; Borden, KL. . Oncogene. Nov 1999, 18 (50): 7091–100. PMID 10597310. doi:10.1038/sj.onc.1203201. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Shin, J; Park, B; Cho, S; Lee, S; Kim, Y; Lee, SO; 等. . J. Biol. Chem. Sep 2004, 279 (39): 40994–1003. PMID 15273249. doi:10.1074/jbc.M407369200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Dahle, Ø; Bakke, O; Gabrielsen, OS. . Exp. Cell Res. Jul 2004, 297 (1): 118–26. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Kurki, S; Latonen, L; Laiho, M. . J. Cell. Sci. Oct 2003, 116 (Pt 19): 3917–25. PMID 12915590. doi:10.1242/jcs.00714. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Bernardi, R; Scaglioni, PP; Bergmann, S; Horn, HF; Vousden, KH; Pandolfi, PP. . Nat. Cell Biol. Jul 2004, 6 (7): 665–72. PMID 15195100. doi:10.1038/ncb1147. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Zhu, H; Wu, L; Maki, CG. . J. Biol. Chem. Dec 2003, 278 (49): 49286–92. PMID 14507915. doi:10.1074/jbc.M308302200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Wei, X; Yu, ZK; Ramalingam, A; Grossman, SR; Yu, JH; Bloch, DB; 等. . J. Biol. Chem. Aug 2003, 278 (31): 29288–97. PMID 12759344. doi:10.1074/jbc.M212215200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Wu, WS; Xu, ZX; Ran, R; Meng, F; Chang, KS. . Oncogene. May 2002, 21 (24): 3925–33. PMID 12032831. doi:10.1038/sj.onc.1205491. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Hong, SH; Yang, Z; Privalsky, ML. . Mol. Cell. Biol. Nov 2001, 21 (21): 7172–82. PMC 99892. PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
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延伸阅读

Zhong, S; Salomoni, P; Pandolfi, PP. . Nat. Cell Biol. 2000, 2 (5): E85–90. PMID 10806494. doi:10.1038/35010583. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
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Beez, S; Demmer, P; Puccetti, E. . PLOS ONE. 2012, 7 (11): e48636. PMC 3494703. PMID 23152790. doi:10.1371/journal.pone.0048636. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

外部链接

MeSH（醫學主題詞）上面的PML+protein,+human（美式英语）

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[pmid15136035-1] Kojic, S; Medeot, E; Guccione, E; Krmac, H; Zara, I; Martinelli, V; 等. . J. Mol. Biol. May 2004, 339 (2): 313–25. PMID 15136035. doi:10.1016/j.jmb.2004.03.071. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10610177-2] Zhong, S; Delva, L; Rachez, C; Cenciarelli, C; Gandini, D; Zhang, H; 等. . Nat. Genet. Nov 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12622724-3] Matsuzaki, K; Minami, T; Tojo, M; Honda, Y; Saitoh, N; Nagahiro, S; 等. . Genes Cells. Mar 2003, 8 (3): 275–86. PMID 12622724. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10077561-4] Doucas, V; Tini, M; Egan, DA; Evans, RM. . Proc. Natl. Acad. Sci. U.S.A. Mar 1999, 96 (6): 2627–32. PMC 15819. PMID 10077561. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12727882-5] Marcello, A; Ferrari, A; Pellegrini, V; Pegoraro, G; Lusic, M; Beltram, F; 等. . EMBO J. May 2003, 22 (9): 2156–66. PMC 156077. PMID 12727882. doi:10.1093/emboj/cdg205. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10525530-6] Ishov, AM; Sotnikov, AG; Negorev, D; Vladimirova, OV; Neff, N; Kamitani, T; 等. . J. Cell Biol. Oct 1999, 147 (2): 221–34. PMC 2174231. PMID 10525530. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10669754-7] Li, H; Leo, C; Zhu, J; Wu, X; O'Neil, J; Park, EJ; 等. . Mol. Cell. Biol. Mar 2000, 20 (5): 1784–96. PMC 85360. PMID 10669754. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11244500-8] Lehembre, F; Müller, S; Pandolfi, PP; Dejean, A. . Oncogene. Jan 2001, 20 (1): 1–9. PMID 11244500. doi:10.1038/sj.onc.1204063. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10684855-9] Zhong, S; Salomoni, P; Ronchetti, S; Guo, A; Ruggero, D; Pandolfi, PP. . J. Exp. Med. Feb 2000, 191 (4): 631–40. PMC 2195846. PMID 10684855. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10938104-10] Tsuzuki, S; Towatari, M; Saito, H; Enver, T. . Mol. Cell. Biol. Sep 2000, 20 (17): 6276–86. PMC 86102. PMID 10938104. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11430826-11] Khan, MM; Nomura, T; Kim, H; Kaul, SC; Wadhwa, R; Shinagawa, T; 等. . Mol. Cell. Jun 2001, 7 (6): 1233–43. PMID 11430826. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11259576-12] Wu, WS; Vallian, S; Seto, E; Yang, WM; Edmondson, D; Roth, S; 等. . Mol. Cell. Biol. Apr 2001, 21 (7): 2259–68. PMC 86860. PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10597310-13] Topcu, Z; Mack, DL; Hromas, RA; Borden, KL. . Oncogene. Nov 1999, 18 (50): 7091–100. PMID 10597310. doi:10.1038/sj.onc.1203201. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid15273249-14] Shin, J; Park, B; Cho, S; Lee, S; Kim, Y; Lee, SO; 等. . J. Biol. Chem. Sep 2004, 279 (39): 40994–1003. PMID 15273249. doi:10.1074/jbc.M407369200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid15194430-15] Dahle, Ø; Bakke, O; Gabrielsen, OS. . Exp. Cell Res. Jul 2004, 297 (1): 118–26. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid12915590-16] Kurki, S; Latonen, L; Laiho, M. . J. Cell. Sci. Oct 2003, 116 (Pt 19): 3917–25. PMID 12915590. doi:10.1242/jcs.00714. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid15195100-17] Bernardi, R; Scaglioni, PP; Bergmann, S; Horn, HF; Vousden, KH; Pandolfi, PP. . Nat. Cell Biol. Jul 2004, 6 (7): 665–72. PMID 15195100. doi:10.1038/ncb1147. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid14507915-18] Zhu, H; Wu, L; Maki, CG. . J. Biol. Chem. Dec 2003, 278 (49): 49286–92. PMID 14507915. doi:10.1074/jbc.M308302200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid12759344-19] Wei, X; Yu, ZK; Ramalingam, A; Grossman, SR; Yu, JH; Bloch, DB; 等. . J. Biol. Chem. Aug 2003, 278 (31): 29288–97. PMID 12759344. doi:10.1074/jbc.M212215200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12032831-20] Wu, WS; Xu, ZX; Ran, R; Meng, F; Chang, KS. . Oncogene. May 2002, 21 (24): 3925–33. PMID 12032831. doi:10.1038/sj.onc.1205491. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11585900-21] Hong, SH; Yang, Z; Privalsky, ML. . Mol. Cell. Biol. Nov 2001, 21 (21): 7172–82. PMC 99892. PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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