视黄酸受体α

视黄酸受体α
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1DKF、1DSZ、3A9E、3KMR、3KMZ、4DQM、5K13
識別號
别名	RARA；, NR1B1, RAR, retinoic acid receptor alpha
外部ID	OMIM：180240 MGI：97856 HomoloGene：20262 GeneCards：RARA
為以下藥物的標靶
	阿达帕林、alitretinoin、tamibarotene、tazarotene、維A酸[1]
基因位置（人类）
染色体	染色体17（人类）[2]
终止	40,357,643 bp[2]
基因位置（小鼠）
染色体	染色体11（小鼠）[3]
终止	98,974,942 bp[3]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• retinoic acid binding; • transcription corepressor activity; • protein domain specific binding; • DNA结合转录因子活性; • nuclear receptor activity; • mRNA 5'-UTR binding; • receptor binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • retinoic acid-responsive element binding; • 转录因子结合; • 金屬離子結合; • steroid hormone receptor activity; • 酶结合; • 鋅離子結合; • 血浆蛋白结合; • drug binding; • DNA结合; • sequence-specific DNA binding; • 转录共激活因子活性; • protein kinase A binding; • protein kinase B binding; • translation repressor activity, nucleic acid binding; • alpha-actinin binding; • protein heterodimerization activity; • chromatin DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • transcription regulatory region sequence-specific DNA binding; • ligand-dependent nuclear receptor transcription coactivator activity; • signaling receptor activity;
細胞組分	• 細胞質; • actin cytoskeleton; • 细胞质的核周区域; • neuron projection; • 细胞核; • cell surface; • nuclear chromatin; • 核质; • neuronal cell body; • 树突; • 细胞质基质; • RNA polymerase II transcription factor complex;
生物學過程	• growth plate cartilage development; • germ cell development; • cellular response to retinoic acid; • ureteric bud development; • positive regulation of interleukin-5 production; • prostate gland development; • limb development; • apoptotic cell clearance; • chondroblast differentiation; • regulation of granulocyte differentiation; • protein phosphorylation; • response to vitamin A; • face development; • 精子发生; • response to ethanol; • negative regulation of cell proliferation; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • response to cytokine; • negative regulation of translation; • regulation of transcription, DNA-templated; • negative regulation of cell differentiation; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to estrogen stimulus; • positive regulation of transcription, DNA-templated; • positive regulation of cell cycle; • regulation of myelination; • positive regulation of neuron differentiation; • 腫瘤壞死因子產生的負調控; • transcription initiation from RNA polymerase II promoter; • trachea cartilage development; • glandular epithelial cell development; • male gonad development; • negative regulation of cartilage development; • response to retinoic acid; • negative regulation of granulocyte differentiation; • multicellular organism growth; • female pregnancy; • negative regulation of apoptotic process; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of interleukin-4 production; • regulation of synaptic plasticity; • outflow tract septum morphogenesis; • negative regulation of transcription, DNA-templated; • negative regulation of interferon-gamma production; • response to estradiol; • negative regulation of translational initiation; • embryonic camera-type eye development; • positive regulation of interleukin-13 production; • neural tube closure; • positive regulation of binding; • retinoic acid receptor signaling pathway; • positive regulation of gene expression; • Sertoli cell fate commitment; • positive regulation of cell proliferation; • positive regulation of T-helper 2 cell differentiation; • ventricular cardiac muscle cell differentiation; • liver development; • cellular response to lipopolysaccharide; • bone development; • hippocampus development; • 訊息傳遞; • positive regulation of transcription from RNA polymerase II promoter; • multicellular organism development; • hormone-mediated signaling pathway; • 细胞分化; • response to lipid; • gland development; • bone morphogenesis; • epithelium development;
	Sources:Amigo / QuickGO
直系同源
	5914
	19401
	ENSG00000131759
	ENSMUSG00000037992
	P10276; Q6I9R7
	P11416
	XM_011525096、NM_000964、NM_001024809、NM_001033603、NM_001145301、NM_001145302、XM_005257552、XM_005257553、XM_005257554、XM_011525095、XM_017024920
	NM_001176528、NM_001177302、NM_001177303、NM_009024、XM_006532592、XM_006532593、XM_006532597、NM_001361954、XM_030245700、XM_030245701、XM_030245702
	NP_000955、NP_001019980、NP_001138773、NP_001138774、XP_005257609、XP_005257610、XP_005257611、XP_011523397、XP_011523398、XP_016880409; NP_000955.1、NP_001138773.1、XP_005257610.1、XP_005257611.1、XP_011523397.1
	NP_001169999、NP_001170773、NP_001170774、NP_033050、XP_006532655、XP_006532656、XP_006532660、NP_001348883、XP_030101560、XP_030101561、XP_030101562
	維基數據

视黄酸受体α（英語：，RAR-α），也称为NR1B1（核受体第一亚族B组成员1，nuclear receptor subfamily 1, group B, member 1）是一个核受体，在人类基因组中由 RARA 基因编码。[6][7]

相互作用

视黄酸受体α可以与下列蛋白質发生进行交互作用：

BAG1,[8]
CLOCK,[9]
CCND3,[10]
NCOA6,[11][12][13]
NCOR1,[14][15]
NCOR2,[16][17]
NPAS2,[9]
NRIP1,[18][19][20]
NR0B2,[21][22]
NR4A2,[23]
PML[24]
RXRA.[25][26]
Src,[27][28]
TADA3L,[29]
ZBTB16.[30]

参考文献

.
GRCh38: Ensembl release 89: ENSG00000131759 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
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Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG. . EMBO J. April 1992, 11 (4): 1409–18. PMC 556590. PMID 1314167.
Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW. . Mol. Cell. Biol. September 1999, 19 (9): 6323–32. PMC 84603. PMID 10454579. doi:10.1128/mcb.19.9.6323.
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Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V. . J. Biol. Chem. November 2002, 277 (47): 45611–8. PMID 12235159. doi:10.1074/jbc.M208447200.
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延伸阅读

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000131759 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2825036-6] . Nature. 1987, 330 (6149): 624–9. PMID 2825036. doi:10.1038/330624a0.

[pmid8244378-7] . Genomics. September 1993, 17 (3): 618–23. PMID 8244378. doi:10.1006/geno.1993.1381.

[pmid9642262-8] Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK. . J. Biol. Chem. July 1998, 273 (27): 16985–92. PMID 9642262. doi:10.1074/jbc.273.27.16985.

[pmid11439184-9] McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. . Cell. June 2001, 105 (7): 877–89. PMID 11439184. doi:10.1016/S0092-8674(01)00401-9.

[pmid12482873-10] Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L. . J. Biol. Chem. February 2003, 278 (8): 6355–62. PMID 12482873. doi:10.1074/jbc.M210697200.

[pmid11158331-11] Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW. . Mol. Endocrinol. February 2001, 15 (2): 241–54. PMID 11158331. doi:10.1210/me.15.2.241.

[pmid10567404-12] Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW. . J. Biol. Chem. November 1999, 274 (48): 34283–93. PMID 10567404. doi:10.1074/jbc.274.48.34283.

[pmid10823961-13] Ko L, Cardona GR, Chin WW. . Proc. Natl. Acad. Sci. U.S.A. May 2000, 97 (11): 6212–7. PMC 18584. PMID 10823961. doi:10.1073/pnas.97.11.6212.

[pmid10336495-14] Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M. . J. Biol. Chem. May 1999, 274 (22): 15901–7. PMID 10336495. doi:10.1074/jbc.274.22.15901.

[pmid9531570-15] Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A. . Blood. April 1998, 91 (8): 2634–42. PMID 9531570.

[pmid11929748-16] Dong S, Tweardy DJ. . Blood. April 2002, 99 (8): 2637–46. PMID 11929748. doi:10.1182/blood.V99.8.2637.

[pmid9256429-17] Hong SH, David G, Wong CW, Dejean A, Privalsky ML. . Proc. Natl. Acad. Sci. U.S.A. August 1997, 94 (17): 9028–33. PMC 23013. PMID 9256429. doi:10.1073/pnas.94.17.9028.

[pmid14581481-18] Hu X, Chen Y, Farooqui M, Thomas MC, Chiang CM, Wei LN. . J. Biol. Chem. January 2004, 279 (1): 319–25. PMID 14581481. doi:10.1074/jbc.M307621200.

[pmid12549917-19] Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN. . Biochemistry. February 2003, 42 (4): 971–9. PMID 12549917. doi:10.1021/bi020497k.

[pmid8887632-20] L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG. . Mol. Cell. Biol. November 1996, 16 (11): 6029–36. PMC 231605. PMID 8887632.

[pmid8650544-21] Seol W, Choi HS, Moore DD. . Science. May 1996, 272 (5266): 1336–9. PMID 8650544. doi:10.1126/science.272.5266.1336.

[pmid9773978-22] Seol W, Hanstein B, Brown M, Moore DD. . Mol. Endocrinol. October 1998, 12 (10): 1551–7. PMID 9773978. doi:10.1210/me.12.10.1551.

[pmid7705655-23] Perlmann T, Jansson L. . Genes Dev. April 1995, 9 (7): 769–82. PMID 7705655. doi:10.1101/gad.9.7.769.

[pmid10610177-24] Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP. . Nat. Genet. November 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463.

[pmid12052862-25] Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P. . Mol. Cell. Biol. July 2002, 22 (13): 4522–34. PMC 133906. PMID 12052862. doi:10.1128/MCB.22.13.4522-4534.2002.

[pmid1314167-26] Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG. . EMBO J. April 1992, 11 (4): 1409–18. PMC 556590. PMID 1314167.

[pmid10454579-27] Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW. . Mol. Cell. Biol. September 1999, 19 (9): 6323–32. PMC 84603. PMID 10454579. doi:10.1128/mcb.19.9.6323.

[pmid12612084-28] He B, Wilson EM. . Mol. Cell. Biol. March 2003, 23 (6): 2135–50. PMC 149467. PMID 12612084. doi:10.1128/MCB.23.6.2135-2150.2003.

[pmid12235159-29] Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V. . J. Biol. Chem. November 2002, 277 (47): 45611–8. PMID 12235159. doi:10.1074/jbc.M208447200.

[pmid14521715-30] Martin PJ, Delmotte MH, Formstecher P, Lefebvre P. . Nucl. Recept. September 2003, 1 (1): 6. PMC 212040. PMID 14521715. doi:10.1186/1478-1336-1-6.