STAT3

Signal transducer and activator of transcription 3 (acute-phase response factor); 信号转导及转录激活蛋白3（急性期反应因子）
	PDB rendering based on 1bg1.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1bg1
标识
代号	STAT3; APRF; HIES
扩展标识	遗传学：102582 鼠基因：103038 同源基因：7960 ChEMBL: 4026 GeneCards: STAT3 Gene
基因本体论描述
分子功能	· RNA polymerase II repressing transcription factor binding; · DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; · calcium ion binding; · protein binding; · transcription factor binding; · protein kinase binding; · CCR5 chemokine receptor binding; · glucocorticoid receptor binding; · sequence-specific DNA binding; · transcription regulatory region DNA binding; · protein dimerization activity;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · cytosol; · plasma membrane;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · temperature homeostasis; · eye photoreceptor cell differentiation; · regulation of transcription, DNA-dependent; · regulation of transcription from RNA polymerase II promoter; · protein import into nucleus; · cellular component movement; · acute-phase response; · signal transduction; · JAK-STAT cascade; · nervous system development; · cell proliferation; · virus-host interaction; · cytokine-mediated signaling pathway; · stem cell maintenance; · sexual reproduction; · intracellular receptor signaling pathway; · response to estradiol stimulus; · cellular response to hormone stimulus; · regulation of multicellular organism growth; · response to drug; · glucose homeostasis; · eating behavior; · response to ethanol; · positive regulation of Notch signaling pathway; · positive regulation of transcription, DNA-dependent; · positive regulation of transcription from RNA polymerase II promoter; · neurotrophin TRK receptor signaling pathway; · astrocyte differentiation; · radial glial cell differentiation; · growth hormone receptor signaling pathway; · JAK-STAT cascade involved in growth hormone signaling pathway; · interleukin-6-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

信号转导及转录激活蛋白3（英語：，STAT3）是一种由人类基因STAT3 编码的转录因子[1]。

功能

STAT3是STAT蛋白家族的成员。受到细胞因子和生长因子的调节，STAT3被受体相关的Janus激酶（JAK）磷酸化，形成同源或异源二聚体，并转移到细胞核，在那里它们起转录激活剂的作用。具体而言，干扰素，表皮生长因子（EGF），白细胞介素（IL-5和IL-6）等配体作用于受体，导致酪氨酸705磷酸化后，STAT3被激活。此外，STAT3可能通过丝裂原活化蛋白激酶（MAPK）[2]和c-src非受体酪氨酸激酶磷酸化丝氨酸727而激活。[3][4]STAT3介导响应细胞刺激的各种基因的表达，因此在许多细胞过程如细胞生长和细胞凋亡中起关键作用。[5]

当原肠胚形成开始时，STAT3缺陷的小鼠胚胎不能在胚胎发育第7天以后发育。[6]看来在这些发育的早期阶段，STAT3激活是胚胎干细胞（ESC）自我更新所必需的。事实上，如果STAT3通过其他方式被激活，LIF可以被省略，该LIF被提供给小鼠ESC培养物以保持其未分化状态。[7]

STAT3对于TH17辅助性T细胞的分化至关重要，TH17辅助性T细胞已涉及多种自體免疫性疾病。[8]在病毒感染期间，缺乏T细胞中STAT3的小鼠显示产生T-滤泡辅助（Tfh）细胞的能力受损，并且不能维持基于抗体的免疫性。[9]

相互作用

STAT3能与下列蛋白質发生交互作用：

AR[10][11]
ELP2[12]
EP300[13]
EGFR[14][15]
HIF1A[16]
JAK1[10][17]
JUN[18]
KHDRBS1[19]
MTOR[20][21]
MYOD1[22]
NDUFA13[23]
NFKB1[24]
NR3C1[25][26]
NCOA1[27]
PML[28]
RAC1[29]
RELA[24]
RET[14][30][31]
RPA2[32]
STAT1[17][33][34]
Src[35]
TRIP10[36]

参考文献

Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T. . Cell. April 1994, 77 (1): 63–71. PMID 7512451. doi:10.1016/0092-8674(94)90235-6.
Tkach, Mercedes; Rosemblit, Cinthia; Rivas, Martín A.; Proietti, Cecilia J.; Díaz Flaqué, María Celeste; Mercogliano, María Florencia; Beguelin, Wendy; Maronna, Esteban; Guzmán, Pablo. . Endocrine-Related Cancer. April 2013, 20 (2): 197–212 [2018-02-11]. ISSN 1479-6821. PMID 23329648. doi:10.1530/ERC-12-0194. （原始内容存档于2018-02-18）.
Silva, Corinne M. . Oncogene. 2004-10-18, 23 (48): 8017–8023 [2018-02-11]. ISSN 0950-9232. PMID 15489919. doi:10.1038/sj.onc.1208159. （原始内容存档于2018-02-18）.
Lim, Cheh Peng; Cao, Xinmin. . Molecular bioSystems. November 2006, 2 (11): 536–550 [2018-02-11]. ISSN 1742-206X. PMID 17216035. doi:10.1039/b606246f. （原始内容存档于2018-02-18）.
Yuan, Zheng-Long; Guan, Ying-Jie; Wang, Lijuan; Wei, Wenyi; Kane, Agnes B.; Chin, Y. Eugene. . Molecular and Cellular Biology. November 2004, 24 (21): 9390–9400 [2018-02-11]. ISSN 0270-7306. PMID 15485908. doi:10.1128/MCB.24.21.9390-9400.2004. （原始内容存档于2018-02-18）.
Takeda, K.; Noguchi, K.; Shi, W.; Tanaka, T.; Matsumoto, M.; Yoshida, N.; Kishimoto, T.; Akira, S. . Proceedings of the National Academy of Sciences of the United States of America. 1997-04-15, 94 (8): 3801–3804 [2018-02-11]. ISSN 0027-8424. PMID 9108058. （原始内容存档于2018-07-24）.
Matsuda, T; Nakamura, T; Nakao, K; Arai, T; Katsuki, M; Heike, T; Yokota, T. . The EMBO Journal. 1999-08-02, 18 (15): 4261–4269. ISSN 0261-4189. PMC 1171502. PMID 10428964. doi:10.1093/emboj/18.15.4261.
Yang, Xuexian O.; Panopoulos, Athanasia D.; Nurieva, Roza; Chang, Seon Hee; Wang, Demin; Watowich, Stephanie S.; Dong, Chen. . The Journal of Biological Chemistry. 2007-03-30, 282 (13): 9358–9363 [2018-02-11]. ISSN 0021-9258. PMID 17277312. doi:10.1074/jbc.C600321200. （原始内容存档于2018-07-23）.
McIlwain, David R.; Grusdat, Melanie; Pozdeev, Vitaly I.; Xu, Haifeng C.; Shinde, Prashant; Reardon, Colin; Hao, Zhenyue; Beyer, Marc; Bergthaler, Andreas. . European Journal of Immunology. February 2015, 45 (2): 418–427 [2018-02-11]. ISSN 1521-4141. PMC 4383653. PMID 25393615. doi:10.1002/eji.201445060. （原始内容存档于2018-07-23）.
Ueda T, Bruchovsky N, Sadar MD. . J. Biol. Chem. 2002, 277 (9): 7076–85. PMID 11751884. doi:10.1074/jbc.M108255200.
Matsuda T, Junicho A, Yamamoto T, Kishi H, Korkmaz K, Saatcioglu F, Fuse H, Muraguchi A. . Biochem. Biophys. Res. Commun. 2001, 283 (1): 179–87. PMID 11322786. doi:10.1006/bbrc.2001.4758.
Collum RG, Brutsaert S, Lee G, Schindler C. . Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (18): 10120–5. PMC 27739. PMID 10954736. doi:10.1073/pnas.170192197.
Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T. . Science. 1999, 284 (5413): 479–82. PMID 10205054. doi:10.1126/science.284.5413.479.
Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. . Mol. Cell. Biol. 2004, 24 (21): 9390–400. PMC 522220. PMID 15485908. doi:10.1128/MCB.24.21.9390-9400.2004.
Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. . J. Biol. Chem. 1999, 274 (24): 17209–18. PMID 10358079. doi:10.1074/jbc.274.24.17209.
Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH. . Exp. Mol. Med. 2008, 40 (5): 479–85. PMC 2679355. PMID 18985005. doi:10.3858/emm.2008.40.5.479.
Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F. . Eur. J. Haematol. 2001, 67 (2): 63–71. PMID 11722592.
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE. . Mol. Cell. Biol. 1999, 19 (10): 7138–46. PMC 84707. PMID 10490649.
Sanchez-Margalet V, Martin-Romero C. . Cell. Immunol. 2001, 211 (1): 30–6. PMID 11585385. doi:10.1006/cimm.2001.1815.
Yokogami K, Wakisaka S, Avruch J, Reeves SA. . Curr. Biol. 2000, 10 (1): 47–50. PMID 10660304. doi:10.1016/S0960-9822(99)00268-7.
Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, Longo DL. . J. Biol. Chem. 2005, 280 (2): 1037–43. PMID 15522880. doi:10.1074/jbc.M405204200.
Kataoka Y, Matsumura I, Ezoe S, Nakata S, Takigawa E, Sato Y, Kawasaki A, Yokota T, Nakajima K, Felsani A, Kanakura Y. . J. Biol. Chem. 2003, 278 (45): 44178–87. PMID 12947115. doi:10.1074/jbc.M304884200.
Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV. . Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (16): 9342–7. PMC 170920. PMID 12867595. doi:10.1073/pnas.1633516100.
Yu Z, Zhang W, Kone BC. . Biochem. J. 2002, 367 (Pt 1): 97–105. PMC 1222853. PMID 12057007. doi:10.1042/BJ20020588.
Lerner L, Henriksen MA, Zhang X, Darnell JE. . Genes Dev. 2003, 17 (20): 2564–77. PMC 218150. PMID 14522952. doi:10.1101/gad.1135003.
Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM. . J. Biol. Chem. 1997, 272 (49): 30607–10. PMID 9388192. doi:10.1074/jbc.272.49.30607.
Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O. . J. Biol. Chem. 2002, 277 (10): 8004–11. PMID 11773079. doi:10.1074/jbc.M111486200.
Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y. . Blood. 2003, 101 (9): 3668–73. PMID 12506013. doi:10.1182/blood-2002-08-2474.
Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL. . Science. 2000, 290 (5489): 144–7. PMID 11021801. doi:10.1126/science.290.5489.144.
Hwang JH, Kim DW, Suh JM, Kim H, Song JH, Hwang ES, Park KC, Chung HK, Kim JM, Lee TH, Yu DY, Shong M. . Mol. Endocrinol. 2003, 17 (6): 1155–66. PMID 12637586. doi:10.1210/me.2002-0401.
Schuringa JJ, Wojtachnio K, Hagens W, Vellenga E, Buys CH, Hofstra R, Kruijer W. . Oncogene. 2001, 20 (38): 5350–8. PMID 11536047. doi:10.1038/sj.onc.1204715.
Kim J, Kim D, Chung J. . Cell Biol. Int. 2000, 24 (7): 467–73. PMID 10875894. doi:10.1006/cbir.2000.0525.
Gunaje JJ, Bhat GJ. . Biochem. Biophys. Res. Commun. 2001, 288 (1): 252–7. PMID 11594781. doi:10.1006/bbrc.2001.5759.
Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, Platt A, Gilmer TM, Fu XY, Chin YE. . J. Biol. Chem. 2002, 277 (34): 30716–23. PMID 12070153. doi:10.1074/jbc.M202823200.
Cao X, Tay A, Guy GR, Tan YH. . Mol. Cell. Biol. 1996, 16 (4): 1595–603. PMC 231145. PMID 8657134.
Chung YH, Cho NH, Garcia MI, Lee SH, Feng P, Jung JU. . J. Virol. 2004, 78 (12): 6489–97. PMC 416526. PMID 15163742. doi:10.1128/JVI.78.12.6489-6497.2004.

延伸阅读

Hoey T, Grusby MJ. . Adv. Immunol. Advances in Immunology. 1999, 71: 145–162. ISBN 978-0-12-022471-5. PMID 9917912. doi:10.1016/S0065-2776(08)60401-0.
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. . Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
Joseph AM, Kumar M, Mitra D. . Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.
Inghirami G; Chiarle R; Simmons WJ; 等. . Cell Cycle. 2006, 4 (9): 1131–3. PMID 16082218. 已忽略未知参数|author-separator= (帮助)
Leeman RJ, Lui VW, Grandis JR. . Expert opinion on biological therapy. 2006, 6 (3): 231–241. PMID 16503733. doi:10.1517/14712598.6.3.231.
Aggarwal BB; Sethi G; Ahn KS; 等. . Ann. N. Y. Acad. Sci. 2007, 1091: 151–169. PMID 17341611. doi:10.1196/annals.1378.063. 已忽略未知参数|author-separator= (帮助)

外部链接

FactorBook STAT3

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid7512451-1] Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T. . Cell. April 1994, 77 (1): 63–71. PMID 7512451. doi:10.1016/0092-8674(94)90235-6.

[2] Tkach, Mercedes; Rosemblit, Cinthia; Rivas, Martín A.; Proietti, Cecilia J.; Díaz Flaqué, María Celeste; Mercogliano, María Florencia; Beguelin, Wendy; Maronna, Esteban; Guzmán, Pablo. . Endocrine-Related Cancer. April 2013, 20 (2): 197–212 [2018-02-11]. ISSN 1479-6821. PMID 23329648. doi:10.1530/ERC-12-0194. （原始内容存档于2018-02-18）.

[3] Silva, Corinne M. . Oncogene. 2004-10-18, 23 (48): 8017–8023 [2018-02-11]. ISSN 0950-9232. PMID 15489919. doi:10.1038/sj.onc.1208159. （原始内容存档于2018-02-18）.

[4] Lim, Cheh Peng; Cao, Xinmin. . Molecular bioSystems. November 2006, 2 (11): 536–550 [2018-02-11]. ISSN 1742-206X. PMID 17216035. doi:10.1039/b606246f. （原始内容存档于2018-02-18）.

[5] Yuan, Zheng-Long; Guan, Ying-Jie; Wang, Lijuan; Wei, Wenyi; Kane, Agnes B.; Chin, Y. Eugene. . Molecular and Cellular Biology. November 2004, 24 (21): 9390–9400 [2018-02-11]. ISSN 0270-7306. PMID 15485908. doi:10.1128/MCB.24.21.9390-9400.2004. （原始内容存档于2018-02-18）.

[6] Takeda, K.; Noguchi, K.; Shi, W.; Tanaka, T.; Matsumoto, M.; Yoshida, N.; Kishimoto, T.; Akira, S. . Proceedings of the National Academy of Sciences of the United States of America. 1997-04-15, 94 (8): 3801–3804 [2018-02-11]. ISSN 0027-8424. PMID 9108058. （原始内容存档于2018-07-24）.

[7] Matsuda, T; Nakamura, T; Nakao, K; Arai, T; Katsuki, M; Heike, T; Yokota, T. . The EMBO Journal. 1999-08-02, 18 (15): 4261–4269. ISSN 0261-4189. PMC 1171502. PMID 10428964. doi:10.1093/emboj/18.15.4261.

[8] Yang, Xuexian O.; Panopoulos, Athanasia D.; Nurieva, Roza; Chang, Seon Hee; Wang, Demin; Watowich, Stephanie S.; Dong, Chen. . The Journal of Biological Chemistry. 2007-03-30, 282 (13): 9358–9363 [2018-02-11]. ISSN 0021-9258. PMID 17277312. doi:10.1074/jbc.C600321200. （原始内容存档于2018-07-23）.

[9] McIlwain, David R.; Grusdat, Melanie; Pozdeev, Vitaly I.; Xu, Haifeng C.; Shinde, Prashant; Reardon, Colin; Hao, Zhenyue; Beyer, Marc; Bergthaler, Andreas. . European Journal of Immunology. February 2015, 45 (2): 418–427 [2018-02-11]. ISSN 1521-4141. PMC 4383653. PMID 25393615. doi:10.1002/eji.201445060. （原始内容存档于2018-07-23）.

[pmid11751884-10] Ueda T, Bruchovsky N, Sadar MD. . J. Biol. Chem. 2002, 277 (9): 7076–85. PMID 11751884. doi:10.1074/jbc.M108255200.

[pmid11322786-11] Matsuda T, Junicho A, Yamamoto T, Kishi H, Korkmaz K, Saatcioglu F, Fuse H, Muraguchi A. . Biochem. Biophys. Res. Commun. 2001, 283 (1): 179–87. PMID 11322786. doi:10.1006/bbrc.2001.4758.

[pmid10954736-12] Collum RG, Brutsaert S, Lee G, Schindler C. . Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (18): 10120–5. PMC 27739. PMID 10954736. doi:10.1073/pnas.170192197.

[pmid10205054-13] Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T. . Science. 1999, 284 (5413): 479–82. PMID 10205054. doi:10.1126/science.284.5413.479.

[pmid15485908-14] Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. . Mol. Cell. Biol. 2004, 24 (21): 9390–400. PMC 522220. PMID 15485908. doi:10.1128/MCB.24.21.9390-9400.2004.

[pmid10358079-15] Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. . J. Biol. Chem. 1999, 274 (24): 17209–18. PMID 10358079. doi:10.1074/jbc.274.24.17209.

[pmid18985005-16] Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH. . Exp. Mol. Med. 2008, 40 (5): 479–85. PMC 2679355. PMID 18985005. doi:10.3858/emm.2008.40.5.479.

[pmid11722592-17] Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F. . Eur. J. Haematol. 2001, 67 (2): 63–71. PMID 11722592.

[pmid10490649-18] Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE. . Mol. Cell. Biol. 1999, 19 (10): 7138–46. PMC 84707. PMID 10490649.

[pmid11585385-19] Sanchez-Margalet V, Martin-Romero C. . Cell. Immunol. 2001, 211 (1): 30–6. PMID 11585385. doi:10.1006/cimm.2001.1815.

[pmid10660304-20] Yokogami K, Wakisaka S, Avruch J, Reeves SA. . Curr. Biol. 2000, 10 (1): 47–50. PMID 10660304. doi:10.1016/S0960-9822(99)00268-7.

[pmid15522880-21] Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, Longo DL. . J. Biol. Chem. 2005, 280 (2): 1037–43. PMID 15522880. doi:10.1074/jbc.M405204200.

[pmid12947115-22] Kataoka Y, Matsumura I, Ezoe S, Nakata S, Takigawa E, Sato Y, Kawasaki A, Yokota T, Nakajima K, Felsani A, Kanakura Y. . J. Biol. Chem. 2003, 278 (45): 44178–87. PMID 12947115. doi:10.1074/jbc.M304884200.

[pmid12867595-23] Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV. . Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (16): 9342–7. PMC 170920. PMID 12867595. doi:10.1073/pnas.1633516100.

[pmid12057007-24] Yu Z, Zhang W, Kone BC. . Biochem. J. 2002, 367 (Pt 1): 97–105. PMC 1222853. PMID 12057007. doi:10.1042/BJ20020588.

[pmid14522952-25] Lerner L, Henriksen MA, Zhang X, Darnell JE. . Genes Dev. 2003, 17 (20): 2564–77. PMC 218150. PMID 14522952. doi:10.1101/gad.1135003.

[pmid9388192-26] Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM. . J. Biol. Chem. 1997, 272 (49): 30607–10. PMID 9388192. doi:10.1074/jbc.272.49.30607.

[pmid11773079-27] Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O. . J. Biol. Chem. 2002, 277 (10): 8004–11. PMID 11773079. doi:10.1074/jbc.M111486200.

[pmid12506013-28] Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y. . Blood. 2003, 101 (9): 3668–73. PMID 12506013. doi:10.1182/blood-2002-08-2474.

[pmid11021801-29] Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL. . Science. 2000, 290 (5489): 144–7. PMID 11021801. doi:10.1126/science.290.5489.144.

[pmid12637586-30] Hwang JH, Kim DW, Suh JM, Kim H, Song JH, Hwang ES, Park KC, Chung HK, Kim JM, Lee TH, Yu DY, Shong M. . Mol. Endocrinol. 2003, 17 (6): 1155–66. PMID 12637586. doi:10.1210/me.2002-0401.

[pmid11536047-31] Schuringa JJ, Wojtachnio K, Hagens W, Vellenga E, Buys CH, Hofstra R, Kruijer W. . Oncogene. 2001, 20 (38): 5350–8. PMID 11536047. doi:10.1038/sj.onc.1204715.

[pmid10875894-32] Kim J, Kim D, Chung J. . Cell Biol. Int. 2000, 24 (7): 467–73. PMID 10875894. doi:10.1006/cbir.2000.0525.

[pmid11594781-33] Gunaje JJ, Bhat GJ. . Biochem. Biophys. Res. Commun. 2001, 288 (1): 252–7. PMID 11594781. doi:10.1006/bbrc.2001.5759.

[pmid12070153-34] Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, Platt A, Gilmer TM, Fu XY, Chin YE. . J. Biol. Chem. 2002, 277 (34): 30716–23. PMID 12070153. doi:10.1074/jbc.M202823200.

[pmid8657134-35] Cao X, Tay A, Guy GR, Tan YH. . Mol. Cell. Biol. 1996, 16 (4): 1595–603. PMC 231145. PMID 8657134.

[pmid15163742-36] Chung YH, Cho NH, Garcia MI, Lee SH, Feng P, Jung JU. . J. Virol. 2004, 78 (12): 6489–97. PMC 416526. PMID 15163742. doi:10.1128/JVI.78.12.6489-6497.2004.