氟替卡松

**氟替卡松**
系统（IUPAC）命名名称
	S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-; 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-; 6,7,8,11,12,14,15,16-octahydrocyclopenta[a]; phenanthrene-17-carbothioate
临床数据
Drugs.com	Monograph
妊娠分级	C(鼻腔內吸入);
给药途径	鼻腔內吸入，局部塗搽
合法狀態
合法状态	UK: 处方药（℞-only） (POM) ; US: 处方药（℞-only） ;
药代动力学数据
生物利用度	0.51% (鼻腔內)
蛋白结合度	91%
代谢	鼻腔內; 肝臟(CYP3A4-中介)
生物半衰期	10小時
排泄	腎臟
识别
CAS注册号	80474-14-2（（丙酸酯）） ; 90566-53-3
ATC代码	D07AC17 R01AD08 R03BA05
PubChem	CID 5311101
DrugBank	DB00588
ChemSpider	4470631
UNII	CUT2W21N7U
KEGG	D07981
ChEBI	CHEBI:5134
ChEMBL	CHEMBL1201396
化学
化学式	C22H27F3O4S
摩尔质量	444.508 g/mol
	SMILES O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;

與糠酸酯（furoate）或丙酸酯（propanoate)的合成品可以用為局部抗炎性、比如鼻炎方面：[2]

氟替卡松（英語：）為一種綜合的糖皮质激素。[1]

參見

Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J., , Lippincott Williams & Wilkins: 600, 2012, ISBN 1451153597.
Spratto, George R.; Woods, Adrienne L., , Cengage Learning: 748, 2012, ISBN 1111310653.

Jarvis B., Faulds D. (1999): Inhaled fluticasone propionate: A review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs, 57(5), 769–803. PMID 10353302
Johnson M. (1995): The anti-inflammatory profile of fluticasone propionate. Allergy, 50(23), 11–14. PMID 7604948
Keating G.M., McCormack P.L. (2007): Salmeterol/fluticasone propionate: a review of its use in the treatment of chronic obstructive pulmonary disease. Drugs, 67(16), 2383–2405. PMID 17983257
Reynolds N.A., Lyseng-Williamson K.A., Wiseman L.R. (2005): Inhaled salmeterol/fluticasone propionate: a review of its use in asthma. Drugs, 65(12), 1715–1734. PMID 16060707
Spencer C.M., Jarvis B. (1999): Salmeterol/fluticasone propionate combination. Drugs, 57(6), 933–940. PMID 10400406
Staresinic A.G., Sorkness C.A. (2000): Fluticasone propionate: A potent inhaled corticosteroid for the treatment of asthma. Expert Opin Pharmacother, 1(6), 1227-1244. PMID 11249490
Avamys, Zusammenfasuung der Merkmale des Arzneimittels (PDF; 440 kB), Stand Dezember 2012, Europäische Arzneimittelagentur.

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