生长激素受体

Growth hormone receptor; 生长激素受体
	PDB rendering based on 1a22.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR
标识
代号	GHR; GHBP
扩展标识	遗传学：600946 鼠基因：95708 同源基因：134 ChEMBL: 1976 GeneCards: GHR Gene
基因本体论描述
分子功能	· growth hormone receptor activity; · protein binding; · peptide hormone binding; · growth factor binding; · protein kinase binding; · protein phosphatase binding; · SH2 domain binding; · protein homodimerization activity; · proline-rich region binding;
细胞成分	· extracellular region; · extracellular space; · nucleus; · mitochondrion; · plasma membrane; · integral to plasma membrane; · cell surface; · integral to membrane; · extrinsic to membrane; · neuronal cell body; · receptor complex; · growth hormone receptor complex;
生物过程	· activation of MAPK activity; · allantoin metabolic process; · citrate metabolic process; · 2-oxoglutarate metabolic process; · succinate metabolic process; · oxaloacetate metabolic process; · isoleucine metabolic process; · valine metabolic process; · creatine metabolic process; · fatty acid metabolic process; · endocytosis; · JAK-STAT cascade; · hormone-mediated signaling pathway; · taurine metabolic process; · receptor internalization; · response to food; · response to estradiol stimulus; · cellular response to insulin stimulus; · cellular response to hormone stimulus; · regulation of multicellular organism growth; · positive regulation of multicellular organism growth; · positive regulation of tyrosine phosphorylation of Stat3 protein; · positive regulation of tyrosine phosphorylation of Stat5 protein; · activation of JAK2 kinase activity; · response to morphine; · multicellular organismal metabolic process; · positive regulation of cell differentiation; · creatinine metabolic process; · response to cycloheximide; · insulin-like growth factor receptor signaling pathway; · positive regulation of peptidyl-tyrosine phosphorylation; · response to glucocorticoid stimulus; · cartilage development involved in endochondral bone morphogenesis; · growth hormone receptor signaling pathway; · JAK-STAT cascade involved in growth hormone signaling pathway; · response to interleukin-1; · negative regulation of neuron death;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

生长激素受体（英語：)是一种由人类基因GHR 编码的蛋白质[1]，GHR的直系同源物[2]广泛存在于各种哺乳动物中。

此基因编码的蛋白是结合生长激素的跨膜受体。

相互作用

生长激素受体能与SGTA[3]、PTPN11[4][5]、JAK激酶2[6][7][8]、SOCS1[9]和CISH[9]发生交互作用。

进化

GHR 基因曾作为动物核DNA系统发育标记[2]，对其10号外显子基因多态性的探究第一次阐释了啮齿目主要类群间的亲缘关系[10][11][12]。GHR也用于较低阶元的分类，在鼠总科[13][14]、八齿鼠科[15]、田鼠亞科[16]、鼠亚科[17]、白足鼠屬[18]等啮齿动物，及熊型總科[19]、猫科[20]等肉食动物以及皮翼目[21]的分类上有重要作用。GHR的9号内含子也用于阐释鼬科[22]、鬣狗科[23]的系统发生。

参考文献

.
. [2014-02-04]. （原始内容存档于2015-09-24）.
Schantl, Julia A; Roza Marcel, De Jong Ad P, Strous Ger J. . Biochem. J. (England). August 2003, 373 (Pt 3): 855–63. ISSN 0264-6021. PMC 1223544. PMID 12735788. doi:10.1042/BJ20021591.
Stofega, M R; Herrington J, Billestrup N, Carter-Su C. . Mol. Endocrinol. (UNITED STATES). September 2000, 14 (9): 1338–50. ISSN 0888-8809. PMID 10976913. doi:10.1210/me.14.9.1338.
Moutoussamy, S; Renaudie F, Lago F, Kelly P A, Finidori J. . J. Biol. Chem. (UNITED STATES). June 1998, 273 (26): 15906–12. ISSN 0021-9258. PMID 9632636. doi:10.1074/jbc.273.26.15906.
Frank, S J; Yi W, Zhao Y, Goldsmith J F, Gilliland G, Jiang J, Sakai I, Kraft A S. . J. Biol. Chem. (UNITED STATES). June 1995, 270 (24): 14776–85. ISSN 0021-9258. PMID 7540178. doi:10.1074/jbc.270.24.14776.
VanderKuur, J A; Wang X, Zhang L, Campbell G S, Allevato G, Billestrup N, Norstedt G, Carter-Su C. . J. Biol. Chem. (UNITED STATES). August 1994, 269 (34): 21709–17. ISSN 0021-9258. PMID 8063815.
Hellgren, G; Jansson J O, Carlsson L M, Carlsson B. . Growth Horm. IGF Res. (SCOTLAND). June 1999, 9 (3): 212–8. ISSN 1096-6374. PMID 10502458. doi:10.1054/ghir.1999.0111.
Ram, P A; Waxman D J. . J. Biol. Chem. (UNITED STATES). December 1999, 274 (50): 35553–61. ISSN 0021-9258. PMID 10585430. doi:10.1074/jbc.274.50.35553.
Adkins RM, Gelke EL, Rowe D, Honeycutt RL. . Mol Biol Evol. 2001, 18 (5): 777–791. PMID 11319262. doi:10.1093/oxfordjournals.molbev.a003860.
Adkins R. M., Walton A. H. & Honeycutt R. L. . Mol. Phylogenet. Evol. 2003, 26 (3): 409–420. PMID 12644400. doi:10.1016/S1055-7903(02)00304-4.
Blanga-Kanfi S., Miranda H., Penn O., Pupko T., DeBry R. W. & Huchon D. . BMC Evol. Biol. 2009, 9: 71. PMC 2674048. PMID 19341461. doi:10.1186/1471-2148-9-71.
Steppan S. J., Adkins R. M. & Anderson J. . Syst. Biol. 2004, 53 (4): 533–553. PMID 15371245. doi:10.1080/10635150490468701.
Rowe K. C., Reno M. L., Richmond D. M., Adkins R. M. & Steppan S. J. . Mol. Phylogenet. Evol. 2008, 47 (1): 84–101. PMID 18313945. doi:10.1016/j.ympev.2008.01.001.
Honeycutt R. L., Rowe D. L. & Gallardo M. H. . Mol. Phylogenet. Evol. 2003, 26 (3): 476–489. PMID 12644405. doi:10.1016/S1055-7903(02)00368-8.
Galewski T., Tilak M., Sanchez S., Chevret P., Paradis E. & Douzery E. J. P. . BMC Evol. Biol. 2006, 6: 80. PMC 1618403. PMID 17029633. doi:10.1186/1471-2148-6-80.
Lecompte E., Aplin K., Denys C., Catzeflis F., Chades M. & Chevret P. . BMC Evol. Biol. 2008, 8: 199. PMC 2490707. PMID 18616808. doi:10.1186/1471-2148-8-199.
Miller J. R. & Engstrom M. D. . J. Mammal. 2008, 89 (5): 1279–1295. doi:10.1644/07-MAMM-A-195.1.
Fulton T. L. & Strobeck C. . Mol. Phylogenet. Evol. 2006, 41 (1): 165–181. PMID 16814570. doi:10.1016/j.ympev.2006.05.025.
Johnson W. E., Eizirik E., Pecon-Slattery J., Murphy W. J., Antunes A., Teeling E. & O'Brien S. J. . Science. 2006, 311 (5757): 73–77. PMID 16400146. doi:10.1126/science.1122277.
Janecka J. E., Helgen K. M., Lim N. T., Baba M., Izawa M., Boeadi & Murphy W. J. . Curr. Biol. 2008, 18 (21): R1001–R1002. PMID 19000793. doi:10.1016/j.cub.2008.09.005.
Koepfli K. P. & Wayne R. K. . Syst. Biol. 2003, 52 (5): 571–593. PMID 14530127. doi:10.1080/10635150390235368.
Koepfli K. P., Jenks S. M., Eizirik E., Zahirpour T., Van Valkenburgh B. & Wayne R. K. . Mol. Phylogenet. Evol. 2006, 38 (3): 603–620. PMID 16503281. doi:10.1016/j.ympev.2005.10.017.

外部链接

MeSH（醫學主題詞）上面的Somatotropin+receptors（美式英语）
Illustration at nih.gov
Overview
Growth Hormone Receptor: Molecule of the Month by Shuchismita Dutta and David Goodsell (April 2004)

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[entrez-1] .

[OrthoMaM-2] . [2014-02-04]. （原始内容存档于2015-09-24）.

[pmid12735788-3] Schantl, Julia A; Roza Marcel, De Jong Ad P, Strous Ger J. . Biochem. J. (England). August 2003, 373 (Pt 3): 855–63. ISSN 0264-6021. PMC 1223544. PMID 12735788. doi:10.1042/BJ20021591.

[pmid10976913-4] Stofega, M R; Herrington J, Billestrup N, Carter-Su C. . Mol. Endocrinol. (UNITED STATES). September 2000, 14 (9): 1338–50. ISSN 0888-8809. PMID 10976913. doi:10.1210/me.14.9.1338.

[pmid9632636-5] Moutoussamy, S; Renaudie F, Lago F, Kelly P A, Finidori J. . J. Biol. Chem. (UNITED STATES). June 1998, 273 (26): 15906–12. ISSN 0021-9258. PMID 9632636. doi:10.1074/jbc.273.26.15906.

[pmid7540178-6] Frank, S J; Yi W, Zhao Y, Goldsmith J F, Gilliland G, Jiang J, Sakai I, Kraft A S. . J. Biol. Chem. (UNITED STATES). June 1995, 270 (24): 14776–85. ISSN 0021-9258. PMID 7540178. doi:10.1074/jbc.270.24.14776.

[pmid8063815-7] VanderKuur, J A; Wang X, Zhang L, Campbell G S, Allevato G, Billestrup N, Norstedt G, Carter-Su C. . J. Biol. Chem. (UNITED STATES). August 1994, 269 (34): 21709–17. ISSN 0021-9258. PMID 8063815.

[pmid10502458-8] Hellgren, G; Jansson J O, Carlsson L M, Carlsson B. . Growth Horm. IGF Res. (SCOTLAND). June 1999, 9 (3): 212–8. ISSN 1096-6374. PMID 10502458. doi:10.1054/ghir.1999.0111.

[pmid10585430-9] Ram, P A; Waxman D J. . J. Biol. Chem. (UNITED STATES). December 1999, 274 (50): 35553–61. ISSN 0021-9258. PMID 10585430. doi:10.1074/jbc.274.50.35553.

[pmid11319262-10] Adkins RM, Gelke EL, Rowe D, Honeycutt RL. . Mol Biol Evol. 2001, 18 (5): 777–791. PMID 11319262. doi:10.1093/oxfordjournals.molbev.a003860.

[pmid12644400-11] Adkins R. M., Walton A. H. & Honeycutt R. L. . Mol. Phylogenet. Evol. 2003, 26 (3): 409–420. PMID 12644400. doi:10.1016/S1055-7903(02)00304-4.

[pmid19341461-12] Blanga-Kanfi S., Miranda H., Penn O., Pupko T., DeBry R. W. & Huchon D. . BMC Evol. Biol. 2009, 9: 71. PMC 2674048. PMID 19341461. doi:10.1186/1471-2148-9-71.

[pmid15371245-13] Steppan S. J., Adkins R. M. & Anderson J. . Syst. Biol. 2004, 53 (4): 533–553. PMID 15371245. doi:10.1080/10635150490468701.

[pmid18313945-14] Rowe K. C., Reno M. L., Richmond D. M., Adkins R. M. & Steppan S. J. . Mol. Phylogenet. Evol. 2008, 47 (1): 84–101. PMID 18313945. doi:10.1016/j.ympev.2008.01.001.

[pmid12644405-15] Honeycutt R. L., Rowe D. L. & Gallardo M. H. . Mol. Phylogenet. Evol. 2003, 26 (3): 476–489. PMID 12644405. doi:10.1016/S1055-7903(02)00368-8.

[pmid17029633-16] Galewski T., Tilak M., Sanchez S., Chevret P., Paradis E. & Douzery E. J. P. . BMC Evol. Biol. 2006, 6: 80. PMC 1618403. PMID 17029633. doi:10.1186/1471-2148-6-80.

[pmid18616808-17] Lecompte E., Aplin K., Denys C., Catzeflis F., Chades M. & Chevret P. . BMC Evol. Biol. 2008, 8: 199. PMC 2490707. PMID 18616808. doi:10.1186/1471-2148-8-199.

[Miller2008-18] Miller J. R. & Engstrom M. D. . J. Mammal. 2008, 89 (5): 1279–1295. doi:10.1644/07-MAMM-A-195.1.

[pmid16814570-19] Fulton T. L. & Strobeck C. . Mol. Phylogenet. Evol. 2006, 41 (1): 165–181. PMID 16814570. doi:10.1016/j.ympev.2006.05.025.

[pmid16400146-20] Johnson W. E., Eizirik E., Pecon-Slattery J., Murphy W. J., Antunes A., Teeling E. & O'Brien S. J. . Science. 2006, 311 (5757): 73–77. PMID 16400146. doi:10.1126/science.1122277.

[pmid19000793-21] Janecka J. E., Helgen K. M., Lim N. T., Baba M., Izawa M., Boeadi & Murphy W. J. . Curr. Biol. 2008, 18 (21): R1001–R1002. PMID 19000793. doi:10.1016/j.cub.2008.09.005.

[pmid14530127-22] Koepfli K. P. & Wayne R. K. . Syst. Biol. 2003, 52 (5): 571–593. PMID 14530127. doi:10.1080/10635150390235368.

[pmid16503281-23] Koepfli K. P., Jenks S. M., Eizirik E., Zahirpour T., Van Valkenburgh B. & Wayne R. K. . Mol. Phylogenet. Evol. 2006, 38 (3): 603–620. PMID 16503281. doi:10.1016/j.ympev.2005.10.017.