美西林

美西林INN:Mecillinam;USAN:Amdinocillin)是一種广谱半合成青霉素[2],對革兰氏阴性菌作用强,也可用來治療傷寒副伤寒[3][4]。其口服利用率很差,匹美西林則是針對此缺陷開發出來的。[5]

美西林
系统(IUPAC)命名名称
(2S,5R,6R)-6-[(E/Z)-(Azepan-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
临床数据
商品名Coactin, Leo, Selexid, Selexidin
Drugs.com国际药品名称
妊娠分级
给药途径靜脈注射肌肉注射
合法狀態
合法状态
药代动力学数据
生物利用度可忽略
蛋白结合度5-10%
代谢肝臟
生物半衰期1-3小時
排泄腎、膽
识别
CAS注册号32887-01-7  
ATC代码J01CA11
PubChemCID 36273
DrugBankDB01163 
ChemSpider33357 N
UNIIV10579P3QZ N
KEGGD02888 N
ChEMBLCHEMBL530 
化学
化学式C15H23N3O3S
摩尔质量325.426 g/mol

這種藥物是荷蘭製藥公司“Leo Pharmaceutical Products”(今利奥制药)研發出來的,最初代號為FL 1060,1972年面世。[6][7]

參考文獻

  1. Nicolle LE. . J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35.
  2. Neu HC. . Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x.
  3. Clarke PD, Geddes AM, McGhie D, Wall JC. . Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648. PMID 820402. doi:10.1136/bmj.2.6026.14.
  4. Geddes AM, Clarke PD. . J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101.
  5. Pham P, Bartlett JG. . Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. (原始内容存档于2009-02-04). Retrieved on August 31, 2008. Freely available with registration.
  6. Lund F, Tybring L. . Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0.
  7. Tybring L, Melchior NH. . Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305. PMID 170856. doi:10.1128/aac.8.3.271. (原始内容存档于2019-12-14).
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