群孕酮

群孕酮英語:,商品名为ReteroidRetroidRetrone)是一种黄体制剂药物,曾经用于治疗月经失调,但现已不再使用[2][3][4][5][6]

群孕酮
系统(IUPAC)命名名称
(8S,9S,10R,13S,14S,17S)-17-acetyl-6-chloro-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
临床数据
商品名Reteroid, Retroid, Retrone
给药途径By mouth
合法狀態
合法状态
  • 处方药(-only)
药代动力学数据
生物利用度≥41–46% (based on urinary excretion)[1]
代谢Liver
代謝產物20α-Dihydrotrengestone[1]
生物半衰期• Trengestone: very short[1]
20α-DHTG: 8–14 hours[1]
排泄Urine: 41–46%[1]
Feces: 30% (unchanged)[1]
识别
CAS注册号5192-84-7
ATC代码None
PubChemCID 56840930
ChemSpider28475379
UNIIVY6S496SVX
ChEBICHEBI:135458
ChEMBLCHEMBL2107518
其他名称Ro 4-8347; Triengestone; 1,6-Didehydro-6-chlororetroprogesterone; 6-Chloro-9β-10α-pregna-1,4,6-triene-3,20-dione
化学
化学式C21H25ClO2
摩尔质量344.879 g/mol

参考文献

  1. Dixon R, Tormey P, Darragh A. . Contraception. March 1975, 11 (3): 339–46. PMID 1116370. doi:10.1016/0010-7824(75)90042-6.
  2. J. Elks. . Springer. 14 November 2014: 259–. ISBN 978-1-4757-2085-3.
  3. Pascale Brudon. . Editions d'en bas. 1983: 93–. ISBN 978-2-8290-0039-3.
  4. Dr. Ian Morton; I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 31 October 1999: 279–. ISBN 978-0-7514-0499-9.
  5. J. Horsky; J. Presl. . Springer Science & Business Media. 6 December 2012: 329–. ISBN 978-94-009-8195-9.
  6. . [2020-09-17]. (原始内容存档于2020-08-18).
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