麦角胺
麦角胺是麦角肽碱,是麦角类生物碱的一种,它在结构与生物化学上和Ergoline密切相关。它的结构和几种神经递质的结构相似,并且具有作为血管收缩剂的生物活性。
![]() | |
![]() | |
系统(IUPAC)命名名称 | |
---|---|
(6aR,9R)-N-((2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide | |
临床数据 | |
商品名 | Cafergot, Ergomar |
Drugs.com | Monograph |
妊娠分级 |
|
给药途径 | Oral |
合法狀態 | |
合法状态 |
|
药代动力学数据 | |
生物利用度 | Intravenous: 100%,[1] Intramuscular: 47%,[2] Oral: <1% [3] (Enhanced by co-administration of caffeine [1]) |
代谢 | Hepatic [2] |
生物半衰期 | 2 hours [2] |
排泄 | 90% biliary [2] |
识别 | |
CAS注册号 | 113-15-5 ![]() |
ATC代码 | N02CA02 |
PubChem | CID 8223 |
IUPHAR/BPS | 149 |
DrugBank | DB00696 ![]() |
ChemSpider | 7930 ![]() |
UNII | PR834Q503T ![]() |
KEGG | D07906 ![]() |
ChEBI | CHEBI:64318 ![]() |
ChEMBL | CHEMBL442 ![]() |
化学 | |
化学式 | C33H35N5O5 |
摩尔质量 | 581.66 g/mol |
| |
|
它用于医学上用于治疗急性偏头痛发作(有时与咖啡因共用)。麦角真菌的药物使用始于16世纪诱导分娩,但其剂量的不确定性阻止了使用。它已被用于防止产后出血(分娩后出血)。它首先在1918年被Sandoz的Arthur Stoll从麦角真菌中分离出来,1921年以商品名Gynergen销售.[4]
参考文献
- Sanders, SW; Haering N; Mosberg H; Jaeger H. . Eur J Clin Pharmacol. 1986, 30 (3): 331–4. PMID 3732370. doi:10.1007/BF00541538.
- Tfelt-Hansen P, Johnson ES. Ergotamine. In: Olesen J, Tfelt-Hansen P, Welch KM, editors. The headaches. New York: Raven Press; 1993. p. 313–22.
- Ibraheem JJ, Paalzow L, Tfelt-Hansen P. Low bioavailability of ergotamine tartrate after oral and rectal administration in migraine sufferers. Br J Clin Pharmacol 1983; 16: 695–9.
- AJ Giannini, AE Slaby. Drugs of Abuse. Oradell, NJ, Medical Economics Books, 1989。
- . drugs.com. [2016-05-20].
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.