5-HT4受體

5-HT4受體
識別號
别名HTR4;, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
外部IDOMIM602164 MGI109246 HomoloGene20243 GeneCardsHTR4
為以下藥物的標靶
维拉佐酮血清素5-甲氧基色胺α-methyl-5-HT莫沙必利renzapridezacoprideprucaloprideRS 67333gr-113808piboserodSB 204070[1]
基因位置(人类)
染色体染色体5(人类)[2]
基因座5q32起始148,451,032 bp[2]
终止148,677,235 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物種人類小鼠
Entrez

3360

15562

Ensembl

ENSG00000164270

ENSMUSG00000026322

UniProt

Q13639

P97288

mRNA序列

NR_104445、NM_000870、NM_001040169、NM_001040172、NM_001040173、NM_001040174、NM_001286410、NM_199453

NM_008313、XM_006525676、XM_006525678、XM_006525680、XM_006525681、XM_006525682、XM_006525683、XM_011246848、NM_001364956、NM_001364957、NM_001364958、NM_001364959、XM_030250343、XM_030250344、XM_030250345、XM_030250346、XM_030250347

蛋白序列

NP_000861、NP_001035259、NP_001035262、NP_001035263、NP_001273339、NP_955525

NP_032339、XP_006525739、XP_006525741、XP_006525743、XP_006525744、XP_006525745、XP_006525746、XP_011245150、XP_017173328、NP_001351885、NP_001351886、NP_001351887、NP_001351888

基因位置(UCSC)Chr 5: 148.45 – 148.68 MbChr 18: 62.32 – 62.5 Mb
PubMed查找[4][5]
維基數據

5-HT4受體5-羥色胺受體4英語:)是在人類上由HTR4基因編碼的蛋白質[6][7]

配體

激動劑

  • BIMU-8
  • Cisapride
  • ML-10302[8]
  • 莫沙必利
  • Prucalopride
  • Renzapride
  • RS-67506
  • Tegaserod
  • Zacopride
  • Metoclopramide
  • 舒必利
  • RS-67333 - partial agonist
  • SL65.0155 - partial agonist
  • CJ-033,466 - partial agonist

拮抗劑

  • Piboserod
  • GR-113,808 (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)[9]
  • GR-125,487
  • RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
  • SB-203,186
  • SB-204,070
  • ([Methoxy-11C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate[10]
  • 洋甘菊(酒精萃取)[11]

參見

參考資料

  1. .
  2. GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017
  3. GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017
  4. . National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. . National Center for Biotechnology Information, U.S. National Library of Medicine.
  6. Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. . Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646.
  7. Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. . FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X.
  8. Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. . Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020.
  9. Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. . British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004. PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x.
  10. Xu R, Hong J, Morse CL, Pike VW. . Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497. PMID 20812727. doi:10.1021/jm100668r.
  11. Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. . Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012.

深入閱讀

外部連結

  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. (原始内容存档于2016-06-05).
  • Human HTR4 genome location and HTR4 gene details page in the UCSC Genome Browser.

5-HT4受體引用了美国国家医学图书馆提供的資料,这些資料属于公共领域

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