A20 (基因)

A20基因(或称为:肿瘤坏死因子α诱导蛋白3英語:,缩写TNFAIP3)是人类六号染色体上的基因[4][5],可由肿瘤坏死因子α(TNF-α)诱导表达,是一种去泛素化酶锌指蛋白,可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白,在刺胞動物門(水母)中也有带有同源结构域的蛋白[6]

TNFAIP3
已知的結構
PDBOrtholog search: PDBe RCSB
識別號
别名TNFAIP3;A20、AISBL、OTUD7C、TNF alpha induced protein 3、TNFA1P2
外部IDOMIM191163 MGI1196377 HomoloGene4582 GeneCardsTNFAIP3
相關疾病
紅斑性狼瘡銀屑病[1]
RNA表达模式


更多參考(基因)表达數據
直系同源
物種人類小鼠
Entrez

7128

21929

Ensembl

ENSG00000118503

ENSMUSG00000019850

UniProt

P21580

Q60769

mRNA序列

XM_011536096、NM_001270507、NM_001270508、NM_006290、XM_005267119、XM_006715555、XM_011536095、XM_024446532、XM_024446533

NM_001166402、NM_009397、XM_006512702

蛋白序列

NP_001257436、NP_001257437、NP_006281、XP_005267176、XP_006715618、XP_011534397、XP_011534398、XP_024302300、XP_024302301

NP_001159874、NP_033423、XP_006512765

基因位置(UCSC)Chr 6: 137.87 – 137.88 Mbn/a
PubMed查找[2][3]
維基數據
檢視/編輯 人類檢視/編輯 小鼠

蛋白质的相互作用

A20蛋白与下列蛋白質进行互作TNIP1[7]TRAF1[8][9]TRAF2[8]IKBKG[10]TAX1BP1[11]YWHAB[12]YWHAZ[12][13]TRAF6[9][14]YWHAH[12][13]

参考文献

  1. .
  2. .
  3. .
  4. Opipari AW Jr; Boguski MS; Dixit VM. . J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.
  5. . (原始内容存档于2010-12-05).
  6. Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, 等. . Frontiers in Immunology. 2018, 9: 1136. PMC 5978004. PMID 29881386. doi:10.3389/fimmu.2018.01136.
  7. Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. . J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159. PMID 10385526. doi:10.1083/jcb.145.7.1471.
  8. Song, H Y; Rothe M; Goeddel D V. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093. PMID 8692885. doi:10.1073/pnas.93.13.6721.
  9. Heyninck, K; Beyaert R. . FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. doi:10.1016/S0014-5793(98)01645-7. 已忽略未知参数|s2cid= (帮助)
  10. Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. . Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.
  11. De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. . Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787. 已忽略未知参数|doi-access= (帮助)
  12. Vincenz, C; Dixit V M. . J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029. 已忽略未知参数|doi-access= (帮助)
  13. De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. . Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.
  14. Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. . Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992. PMID 11463333. doi:10.1042/0264-6021:3570617.

外部链接

  • PDBUniProt可用的所有結構信息之概述:P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB
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