C-Myc

C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化，有多种功能：在细胞周期进程、细胞凋亡和细胞轉化中发挥作用。[5]

c-Myc
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名MYC；, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc
外部IDOMIM：190080 MGI：97250 HomoloGene：31092 GeneCards：MYC
基因位置（人类）
染色体8號染色體[1]
基因座8q24.21起始127,735,434 bp[1]
终止127,742,951 bp[1]
直系同源
物種人類小鼠
Entrez

4609

17869

Ensembl

ENSG00000136997

ENSMUSG00000022346

UniProt

P01106

P01108

mRNA​序列

NM_002467
NM_001354870

NM_001177352
NM_001177353
NM_001177354
NM_010849

蛋白序列

NP_002458
NP_001341799

NP_001170823
NP_001170824
NP_001170825
NP_034979

基因位置​（UCSC）Chr 8: 127.74 – 127.74 MbChr 15: 61.99 – 61.99 Mb
PubMed​查找[3][4]
維基數據

相互作用

Myc可与以下蛋白质发生交互作用：

参考文献
  1. GRCh38: Ensembl release 89: ENSG00000136997 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017
  3. . National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. . National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. . [2018-03-02]. （原始内容存档于2019-05-11）.
  6. Park J, Wood MA, Cole MD. . Molecular and Cellular Biology. March 2002, 22 (5): 1307–16. PMC 134713. PMID 11839798. doi:10.1128/mcb.22.5.1307-1316.2002.
  7. Li H, Lee TH, Avraham H. . The Journal of Biological Chemistry. June 2002, 277 (23): 20965–73. PMID 11916966. doi:10.1074/jbc.M112231200.
  8. Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG, Rosen EM. . Molecular and Cellular Biology. December 2003, 23 (23): 8668–90. PMC 262673. PMID 14612409. doi:10.1128/mcb.23.23.8668-8690.2003.
  9. Zhou C, Liu J. . Biochemical and Biophysical Research Communications. March 2003, 303 (1): 130–6. PMID 12646176. doi:10.1016/s0006-291x(03)00318-8.
  10. Wang Q, Zhang H, Kajino K, Greene MI. . Oncogene. October 1998, 17 (15): 1939–48. PMID 9788437. doi:10.1038/sj.onc.1202403.
  11. Jin Z, Gao F, Flagg T, Deng X. . The Journal of Biological Chemistry. September 2004, 279 (38): 40209–19. PMID 15210690. doi:10.1074/jbc.M404056200.
  12. Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM. . Oncogene. August 2003, 22 (36): 5707–11. PMID 12944920. doi:10.1038/sj.onc.1206800.
  13. Dingar D, Kalkat M, Chan PK, Srikumar T, Bailey SD, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Penn LZ, Raught B. . Journal of Proteomics. April 2015, 118 (12): 95–111. PMID 25452129. doi:10.1016/j.jprot.2014.09.029.
  14. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L, Fuks F. . The EMBO Journal. January 2005, 24 (2): 336–46. PMC 545804. PMID 15616584. doi:10.1038/sj.emboj.7600509.
  15. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM. . Cell. August 2001, 106 (3): 297–307. PMID 11509179. doi:10.1016/s0092-8674(01)00450-0.
  16. Roy AL, Carruthers C, Gutjahr T, Roeder RG. . Nature. September 1993, 365 (6444): 359–61. PMID 8377829. doi:10.1038/365359a0.
  17. Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM, Amati B. . EMBO Reports. June 2003, 4 (6): 575–80. PMC 1319201. PMID 12776177. doi:10.1038/sj.embor.embor861.
  18. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. . Nature Genetics. January 2008, 40 (1): 43–50. PMC 2628762. PMID 18066065. doi:10.1038/ng.2007.30.
  19. Koscianska E, Baev V, Skreka K, Oikonomaki K, Rusinov V, Tabler M, Kalantidis K. . BMC Molecular Biology. 2007, 8: 79. PMC 2096627. PMID 17877811. doi:10.1186/1471-2199-8-79.
  20. Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M. . The Journal of Biological Chemistry. May 2005, 280 (20): 20086–93. PMID 15769738. doi:10.1074/jbc.M410036200.
  21. Gupta S, Davis RJ. . FEBS Letters. October 1994, 353 (3): 281–5. PMID 7957875. doi:10.1016/0014-5793(94)01052-8.
  22. Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ. . Proceedings of the National Academy of Sciences of the United States of America. July 1997, 94 (14): 7337–42. PMC 23822. PMID 9207092. doi:10.1073/pnas.94.14.7337.
  23. Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y. . The Journal of Biological Chemistry. November 1999, 274 (46): 32580–7. PMID 10551811. doi:10.1074/jbc.274.46.32580.
  24. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. . Molecular Systems Biology. 2007, 3: 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134.
  25. McMahon SB, Wood MA, Cole MD. . Molecular and Cellular Biology. January 2000, 20 (2): 556–62. PMC 85131. PMID 10611234. doi:10.1128/mcb.20.2.556-562.2000.
  26. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. . Cell. August 1998, 94 (3): 363–74. PMID 9708738. doi:10.1016/s0092-8674(00)81479-8.
  27. Cheng SW, Davies KP, Yung E, Beltran RJ, Yu J, Kalpana GV. . Nature Genetics. May 1999, 22 (1): 102–5. PMID 10319872. doi:10.1038/8811.
  28. Mac Partlin M, Homer E, Robinson H, McCormick CJ, Crouch DH, Durant ST, Matheson EC, Hall AG, Gillespie DA, Brown R. . Oncogene. February 2003, 22 (6): 819–25. PMID 12584560. doi:10.1038/sj.onc.1206252.
  29. Blackwood EM, Eisenman RN. . Science. March 1991, 251 (4998): 1211–7. PMID 2006410. doi:10.1126/science.2006410.
  30. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. . Proceedings of the National Academy of Sciences of the United States of America. October 2002, 99 (22): 14189–94. PMC 137859. PMID 12391307. doi:10.1073/pnas.232310199.
  31. Billin AN, Eilers AL, Queva C, Ayer DE. . The Journal of Biological Chemistry. December 1999, 274 (51): 36344–50. PMID 10593926. doi:10.1074/jbc.274.51.36344.
  32. Gupta K, Anand G, Yin X, Grove L, Prochownik EV. . Oncogene. March 1998, 16 (9): 1149–59. PMID 9528857. doi:10.1038/sj.onc.1201634.
  33. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R. . The EMBO Journal. May 1997, 16 (10): 2892–906. PMC 1169897. PMID 9184233. doi:10.1093/emboj/16.10.2892.
  34. Nair SK, Burley SK. . Cell. January 2003, 112 (2): 193–205. PMID 12553908. doi:10.1016/s0092-8674(02)01284-9.
  35. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE. . Oncogene. April 1999, 18 (15): 2489–98. PMID 10229200. doi:10.1038/sj.onc.1202611.
  36. Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A. . Oncogene. July 2000, 19 (29): 3266–77. PMID 10918583. doi:10.1038/sj.onc.1203634.
  37. Guo Q, Xie J, Dang CV, Liu ET, Bishop JM. . Proceedings of the National Academy of Sciences of the United States of America. August 1998, 95 (16): 9172–7. PMC 21311. PMID 9689053. doi:10.1073/pnas.95.16.9172.
  38. Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. . Genes to Cells. August 1998, 3 (8): 549–65. PMID 9797456. doi:10.1046/j.1365-2443.1998.00206.x.
  39. Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K. . Journal of Cell Science. April 2001, 114 (Pt 8): 1533–44. PMID 11282029.
  40. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. . The Journal of Biological Chemistry. August 1999, 274 (34): 24270–9. PMID 10446203. doi:10.1074/jbc.274.34.24270.
  41. Uramoto H, Izumi H, Ise T, Tada M, Uchiumi T, Kuwano M, Yasumoto K, Funa K, Kohno K. . The Journal of Biological Chemistry. August 2002, 277 (35): 31694–702. PMID 12080043. doi:10.1074/jbc.M200266200.
  42. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E. . The Journal of Biological Chemistry. May 2003, 278 (22): 20405–12. PMC 4031917. PMID 12660246. doi:10.1074/jbc.M211795200.
  43. Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H. . The Journal of Biological Chemistry. November 1998, 273 (45): 29794–800. PMID 9792694. doi:10.1074/jbc.273.45.29794.
  44. Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H. . The Journal of Biological Chemistry. November 2001, 276 (48): 45137–44. PMID 11567024. doi:10.1074/jbc.M106127200.
  45. Feng XH, Liang YY, Liang M, Zhai W, Lin X. . Molecular Cell. January 2002, 9 (1): 133–43. PMID 11804592. doi:10.1016/s1097-2765(01)00430-0.
  46. Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H. . The Journal of Biological Chemistry. February 2003, 278 (7): 5132–40. PMID 12446731. doi:10.1074/jbc.M206733200.
  47. Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R, Eilers M. . The EMBO Journal. April 1995, 14 (7): 1508–19. PMC 398238. PMID 7729426.
  48. Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP. . Molecular Cell. May 2015, 58 (3): 440–52. PMC 4427524. PMID 25818646. doi:10.1016/j.molcel.2015.02.028.
  49. Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K. . Science. December 1993, 262 (5141): 1889–92. PMID 8266081. doi:10.1126/science.8266081.
  50. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M. . Nature Cell Biology. April 2001, 3 (4): 392–9. PMID 11283613. doi:10.1038/35070076.
  51. Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M. . The EMBO Journal. September 1997, 16 (18): 5672–86. PMC 1170199. PMID 9312026. doi:10.1093/emboj/16.18.5672.
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