CD2AP

CD2相關蛋白質; ()
	基於2j6f的PDB繪製。
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2FEI, 2J6F, 2J6K, 2J6O, 2J7I, 3AA6, 3LK4, 3U23
标识
代号	CD2AP; CMS
扩展标识	遗传学：604241 鼠基因：1330281 同源基因：7663 GeneCards: CD2AP Gene
基因本体论描述
分子功能	· vascular endothelial growth factor receptor binding; · structural constituent of cytoskeleton; · protein binding; · beta-catenin binding; · protein C-terminus binding; · SH3 domain binding; · protein complex binding; · cadherin binding;
细胞成分	· ruffle; · cytoplasm; · plasma membrane; · actin cytoskeleton; · endocytic vesicle; · filamentous actin; · perinuclear region of cytoplasm; · extracellular vesicular exosome;
生物过程	· protein complex assembly; · substrate-dependent cell migration, cell extension; · mitotic nuclear division; · signal transduction; · vesicle organization; · single organismal cell-cell adhesion; · proteasome-mediated ubiquitin-dependent protein catabolic process; · regulation of receptor-mediated endocytosis;
	Sources: Amigo / QuickGO
直系同源体

該基因編碼一種調節肌動蛋白細胞骨架的"支架分子"(在神經元通路中的廣大連結區域聚積的蛋白分子)。該蛋白質直接與絲狀肌動蛋白、及通過多種肌動蛋白結合位點的各種細胞膜的蛋白質、SH3結構域(SH3 domain)，以及含有SH3結構域結合位點之"富含脯氨酸區域"(proline-rich region)等交互作用。胞質蛋白定位於膜皺褶(Membrane ruffling)，脂筏(Lipid raft)和細胞的前緣。它牽涉到在受體的內吞作用和"胞質分裂"(cytokinesis)發生動態肌動蛋白重塑(actin remodeling)和膜交換。該基因的"單倍劑量不足"(Haploinsufficiency)牽涉到易感性的腎小球疾病。[2]

CD2相關蛋白質()是在人類中由CD2AP基因所編碼的蛋白質。[1][2]

交互作用

CD2AP已顯示出與NPHS2、[3]腎病蛋白、[4] CBL基因(CBL (gene))，[5][6][7] 及RAB4A[7]等有蛋白質交互作用

參見

局灶節段性腎小球硬化症

註釋

Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H. . Proc Natl Acad Sci USA. Jun 1999, 96 (11): 6211–6. PMC 26861. PMID 10339567. doi:10.1073/pnas.96.11.6211.
. （原始内容存档于2010-03-08）.
Schwarz, K; Simons M; Reiser J; Saleem M A; Faul C; Kriz W; Shaw A S; Holzman L B; Mundel P. . J. Clin. Invest. (United States). Dec 2001, 108 (11): 1621–9. ISSN 0021-9738. PMC 200981. PMID 11733557. doi:10.1172/JCI12849.
Lehtonen, Sanna; Lehtonen Eero; Kudlicka Krystyna; Holthöfer Harry; Farquhar Marilyn G. . Am. J. Pathol. (United States). Sep 2004, 165 (3): 923–36. ISSN 0002-9440. PMC 1618613. PMID 15331416. doi:10.1016/S0002-9440(10)63354-8.
Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan. . J. Cell. Sci. (England). May 2004, 117 (Pt 12): 2557–68. ISSN 0021-9533. PMID 15128873. doi:10.1242/jcs.01148.
Kirsch, K H; Georgescu M M; Shishido T; Langdon W Y; Birge R B; Hanafusa H. . J. Biol. Chem. (United States). Feb 2001, 276 (7): 4957–63. ISSN 0021-9258. PMID 11067845. doi:10.1074/jbc.M005784200.
Cormont, Mireille; Metón Isidoro, Mari Muriel, Monzo Pascale, Keslair Frédérique, Gaskin Chantell, McGraw Timothy E, Le Marchand-Brustel Yannick. . Traffic (Denmark). Feb 2003, 4 (2): 97–112. ISSN 1398-9219. PMID 12559036. doi:10.1034/j.1600-0854.2003.40205.x.

延伸閱讀

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Schwarz K, Simons M, Reiser J; 等. . J. Clin. Invest. 2002, 108 (11): 1621–9. PMC 200981. PMID 11733557. doi:10.1172/JCI12849.
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Haglund K, Ivankovic-Dikic I, Shimokawa N; 等. . J. Cell. Sci. 2004, 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148.
Lehtonen S, Lehtonen E, Kudlicka K; 等. . Am. J. Pathol. 2004, 165 (3): 923–36. PMC 1618613. PMID 15331416. doi:10.1016/S0002-9440(10)63354-8.
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[pmid10339567-1] Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H. . Proc Natl Acad Sci USA. Jun 1999, 96 (11): 6211–6. PMC 26861. PMID 10339567. doi:10.1073/pnas.96.11.6211.

[entrez-2] . （原始内容存档于2010-03-08）.

[pmid11733557-3] Schwarz, K; Simons M; Reiser J; Saleem M A; Faul C; Kriz W; Shaw A S; Holzman L B; Mundel P. . J. Clin. Invest. (United States). Dec 2001, 108 (11): 1621–9. ISSN 0021-9738. PMC 200981. PMID 11733557. doi:10.1172/JCI12849.

[pmid15331416-4] Lehtonen, Sanna; Lehtonen Eero; Kudlicka Krystyna; Holthöfer Harry; Farquhar Marilyn G. . Am. J. Pathol. (United States). Sep 2004, 165 (3): 923–36. ISSN 0002-9440. PMC 1618613. PMID 15331416. doi:10.1016/S0002-9440(10)63354-8.

[pmid15128873-5] Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan. . J. Cell. Sci. (England). May 2004, 117 (Pt 12): 2557–68. ISSN 0021-9533. PMID 15128873. doi:10.1242/jcs.01148.

[pmid11067845-6] Kirsch, K H; Georgescu M M; Shishido T; Langdon W Y; Birge R B; Hanafusa H. . J. Biol. Chem. (United States). Feb 2001, 276 (7): 4957–63. ISSN 0021-9258. PMID 11067845. doi:10.1074/jbc.M005784200.

[pmid12559036-7] Cormont, Mireille; Metón Isidoro, Mari Muriel, Monzo Pascale, Keslair Frédérique, Gaskin Chantell, McGraw Timothy E, Le Marchand-Brustel Yannick. . Traffic (Denmark). Feb 2003, 4 (2): 97–112. ISSN 1398-9219. PMID 12559036. doi:10.1034/j.1600-0854.2003.40205.x.